2-Bromo-4-(trifluoro methyl)pryrimidine
- Product Name
- 2-Bromo-4-(trifluoro methyl)pryrimidine
- CAS No.
- 785777-87-9
- Chemical Name
- 2-Bromo-4-(trifluoro methyl)pryrimidine
- Synonyms
- 2-Bromo-4-(trifluoro methyl)pryrimidine;Pyrimidine, 2-bromo-4-(trifluoromethyl)-;2-Bromo-4-(trifluoro methyl)pryrimidine ISO 9001：2015 REACH
- CBNumber
- CB01154401
- Molecular Formula
- C5H2BrF3N2
- Formula Weight
- 226.98
- MOL File
- 785777-87-9.mol
2-Bromo-4-(trifluoro methyl)pryrimidine Property
- Melting point:
- 21-23 °C
- Boiling point:
- 247℃
- Density
- 1.807
- refractive index
- 1.475
- Flash point:
- 103℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- low melting solid
- pka
- -4.12±0.20(Predicted)
- color
- Light yellow
Safety
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- B699025
- Product name
- 2-Bromo-4-(trifluoromethyl)pyrimidine
- Packaging
- 250mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 3H32-B-6E
- Product name
- 2-Bromo-4-(trifluoromethyl)pyrimidine
- Purity
- 97%
- Packaging
- 1g
- Price
- $100
- Updated
- 2021/12/16
- Product number
- 074712
- Product name
- 2-Bromo-4-(trifluoromethyl)pyrimidine
- Purity
- 95+%
- Packaging
- 1g
- Price
- $120
- Updated
- 2021/12/16
- Product number
- PC908649
- Product name
- 2-Bromo-4-(trifluoromethyl)pyrimidine
- Purity
- 97%
- Packaging
- 5g
- Price
- $201
- Updated
- 2021/12/16
- Product number
- 074712
- Product name
- 2-Bromo-4-(trifluoromethyl)pyrimidine
- Purity
- 95+%
- Packaging
- 5g
- Price
- $442
- Updated
- 2021/12/16
2-Bromo-4-(trifluoro methyl)pryrimidine Chemical Properties,Usage,Production
Synthesis
104048-92-2
785777-87-9
General procedure for the synthesis of 2-bromo-4-trifluoromethylpyrimidines from 4-(trifluoromethyl)pyrimidin-2(1H)-ones:[0604] Synthesis of 2-bromo-4-(trifluoromethyl)pyrimidines:[0605] To a stirred toluene solution (40 mL) of 6-(trifluoromethyl)-1,2-dihydropyrimidin-2-ol (2 g, 12.19 mmol), protected by argon gas To this solution, phosphorus bromide (5.24 g, 18.20 mmol) and N,N-dimethylaniline (156 mg, 1.20 mmol) were sequentially added at room temperature. The reaction mixture was heated to 100 °C and stirred for 3 hours. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction mixture was diluted with 50 mL of water and extracted with hexane (2 x 50 mL). The organic phases were combined, washed with 50 mL of water, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to afford 2-bromo-4-(trifluoromethyl)pyrimidine as a light yellow oil (800 mg, 29% yield). The product was characterized by 1H-NMR (CDCl3, 500MHz): δ 8.82 (d, 1H), 7.64 (d, 1H); TLC conditions: 10% EtOAc/hexane (Rf 0.8).
References
[1] Patent: WO2013/142269, 2013, A1. Location in patent: Paragraph 0604; 0605; 0606
2-Bromo-4-(trifluoro methyl)pryrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
2-Bromo-4-(trifluoro methyl)pryrimidine Suppliers
- Tel
- --
- Fax
- --
- contact@achemica.com
- Country
- Switzerland
- ProdList
- 6155
- Advantage
- 50
View Lastest Price from 2-Bromo-4-(trifluoro methyl)pryrimidine manufacturers
- Product
- 2-Bromo-4-(trifluoro methyl)pryrimidine 785777-87-9
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-12-01
- Product
- 2-Bromo-4-(trifluoro methyl)pryrimidine 785777-87-9
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2020-02-18