Inotilone

Product Name: Inotilone
CAS No.: 906366-79-8
Chemical Name: Inotilone
Synonyms: Inotilone;Inotilone, 10 mM in DMSO;2-[(3,4-dihydroxyphenyl)methylidene]-5-methyl-3-furanone;(2E)-2-[(3,4-Dihydroxyphenyl)methylene]-5-methyl-3(2H)-furanone;(2Z)-2-[(3,4-dihydroxyphenyl)methylene]-5-methyl-3(2H)-furanone;3(2H)-Furanone, 2-[(3,4-dihydroxyphenyl)methylene]-5-methyl-, (2Z)-
CBNumber: CB01176375
Molecular Formula: C12H10O4
Formula Weight: 218.21
MOL File: 906366-79-8.mol

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Inotilone Property

Melting point:: 177.4 °C
Boiling point:: 491.9±45.0 °C(Predicted)
Density: 1.433±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: ≤1mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide
form: crystalline solid
pka: 8.58±0.35(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 10010089
Product name: Inotilone
Purity: ≥98%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 10010089
Product name: Inotilone
Purity: ≥98%
Packaging: 5mg
Price: $161
Updated: 2024/03/01

Cayman Chemical

Product number: 10010089
Product name: Inotilone
Purity: ≥98%
Packaging: 10mg
Price: $299
Updated: 2024/03/01

Cayman Chemical

Product number: 10010089
Product name: Inotilone
Purity: ≥98%
Packaging: 25mg
Price: $638
Updated: 2024/03/01

TRC

Product number: I666500
Product name: Inotilone
Packaging: 5mg
Price: $155
Updated: 2021/12/16

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Inotilone Chemical Properties,Usage,Production

Uses

A potent COX-2 inhibitor. Inotilone is used for treating degenerative conditions from overexpression of iNOS.

Biological Activity

inotilone is a cyclooxygenase (cox) inhibitor.many of nonsteroidal anti-inflammatory drugs (nsaids) target cyclooxygenases (cox), which catalyze the first two steps in the biosynthesis of the prostaglandins from the substrate arachidonic acid.

in vitro

inotilone was tested as the inhibitor of mitogen-activated protein kinase, nuclear factor-κb (nf-κb), and matrix-metalloproteinase (mmp)-9 protein expressions in lps-stimulated raw264.7 cells. when raw264.7 macrophages were treated with inotilone with lps, a significant concentration-dependent inhibition of no production was detected. it was also found that inotilone could block the protein expression of inos, nf-κb, and mmp-9 in lps-stimulated raw264.7 macrophages [1].

in vivo

in in vivo tests, inotilone decreased the paw edema after carr administration, and it increased the activities of catalase (cat), superoxide dismutase (sod), and glutathione peroxidase (gpx). inotilone also significantly attenuated the malondialdehyde (mda) level in the edema paw. inotilone decreased the no and tumor necrosis factor (tnf-α) levels on serum after carr injection. in addition, an intraperitoneal injection treatment with inotilone could diminish neutrophil infiltration into sites of inflammation, as did indomethacin [1].

IC 50

0.03 and 0.36 μm for cox-2 and cox-1, respectively

References

[1] huang gj, huang ss, deng js. anti-inflammatory activities of inotilone from phellinus linteus through the inhibition of mmp-9, nf-κb, and mapk activation in vitro and in vivo. plos one. 2012;7(5):e35922.

Inotilone Preparation Products And Raw materials

Raw materials

Preparation Products

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Inotilone Suppliers

Canada 1 China 23 India 1 United States 6 USA 1 Global 32

J & K SCIENTIFIC LTD.

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906366-79-8, InotiloneRelated Search:

Inotilone

(2E)-2-[(3,4-Dihydroxyphenyl)methylene]-5-methyl-3(2H)-furanone

Inotilone

2-[(3,4-dihydroxyphenyl)methylidene]-5-methyl-3-furanone

3(2H)-Furanone, 2-[(3,4-dihydroxyphenyl)methylene]-5-methyl-, (2Z)-

(2Z)-2-[(3,4-dihydroxyphenyl)methylene]-5-methyl-3(2H)-furanone

Inotilone, 10 mM in DMSO

906366-79-8

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