Lisinopril R,S,S-Diketopiperazine

Product Name: Lisinopril R,S,S-Diketopiperazine
CAS No.: 219677-82-4
Chemical Name: Lisinopril R,S,S-Diketopiperazine
Synonyms: Lsinopril imp D;Lisinopril-EP-Imp-D;Lisinopril EP IMpurity D;Lisinopril diketopipirazine;Lisinopril specified impurity D;Lisinopril R,S,S-Diketopiperazine;Lisinopril Dihydrate EP Impurity D;(2S)-2-[(3S,8aR)-3-(4-Aminobutyl)-1;Lisinopril (S,S,R)-Diketopiperazine (~90%);LisinoprilEPImpurityDHCl-DiketopiperazineHCl)
CBNumber: CB01176395
Molecular Formula: C21H29N3O4
Formula Weight: 387.47
MOL File: 219677-82-4.mol

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Lisinopril R,S,S-Diketopiperazine Property

Melting point:: >214oC (dec.)
Boiling point:: 650.8±55.0 °C(Predicted)
Density: 1.27±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO (Slightly), Methanol (Slightly), Water (Slightly)
pka: 3.56±0.10(Predicted)
form: Solid
color: White to Off-White
Stability:: Hygroscopic
Major Application: pharmaceutical
InChI: 1S/C21H29N3O4/c22-13-5-4-9-17-19(25)23-14-6-10-16(23)20(26)24(17)18(21(27)28)12-11-15-7-2-1-3-8-15/h1-3,7-8,16-18H,4-6,9-14,22H2,(H,27,28)/t16-,17+,18+/m1/s1
InChIKey: FUEMHWCBWYXAOU-SQNIBIBYSA-N
SMILES: [N+H3]CCCC[C@@H]1N(C(=O)[C@@H]3N(CCC3)C1=O)[C@@H](CCc2ccccc2)C(=O)[O-]

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Safety

WGK Germany: WGK 3
Storage Class: 13 - Non Combustible Solids

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: L468975
Product name: Lisinopril(S,S,R)-Diketopiperazine(~90%)
Packaging: 5mg
Price: $640
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0000627
Product name: LISINOPRIL R,S,S-DIKETOPIPERAZINE
Purity: 95.00%
Packaging: 1MG
Price: $757.97
Updated: 2021/12/16

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Lisinopril R,S,S-Diketopiperazine Chemical Properties,Usage,Production

Uses

Lisinopril impurity

Uses

Lisinopril (S,S,R)-Diketopiperazine (Lisinopril EP Impurity D) is an impurity of Lisinopril (L468985), an orally active angiotensin-converting enzyme (ACE) inhibitor (1).

Definition

ChEBI: Lisinopril (8r,s)-diketopiperazine is a dipeptide.

Lisinopril R,S,S-Diketopiperazine Preparation Products And Raw materials

Raw materials

Preparation Products

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Lisinopril R,S,S-Diketopiperazine Suppliers

Canada 1 China 41 India 8 United States 6 Global 56

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219677-82-4, Lisinopril R,S,S-DiketopiperazineRelated Search:

Lisinopril Dihydrate Lisinopril EP Impurity E Lisinopril S,S,S-Diketopiperazine Lisinopril Cyclohexyl Analog N2-(S)-1-Carboxy-3-phenylpropyl-L-lysine DL-Homophenylalanine p-Toluenesulfonic acid monohydrate Lisinopril (3-OXO-1-PIPERAZINYL)ACETIC ACID Pyrrolo[1,2-a]pyrazine, octahydro-, (8aR)- (9CI) (R)-HEXAHYDROPYRROLO[1,2-A]PYRAZIN-1(2H)-ONE Lisinopril R,S,S-Diketopiperazine

(2S)-2-[(3S,8aR)-3-(4-Aminobutyl)-1,4-dioxohexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-4-phenylbutanoic Acid

(2S)-2-[(3S,8aR)-3-(4-Aminobutyl)-1,4-dioxohexahydropyrrolo[1,2-α]pyrazin-2(1H)-yl]-4-phenylbutanoic Acid

Pyrrolo[1,2-a]pyrazine-2(1H)-acetic acid, 3-(4-aMinobutyl)hexahydro-1,4-dioxo-a-(2-phenylethyl)-, (aS,3S,8aR)-

Lisinopril EP IMpurity D

Lisinopril Impurity 4(Lisinopril EP Impurity D)

Lisinopril-EP-Imp-D

Lisinopril impurity 3/Lisinopril EP Impurity D/R,S,S-Diketopiperazine

(2S)-2-[(3S,8aR)-3-(4-Aminobutyl)-1

Lisinopril (S,S,R)-Diketopiperazine (~90%)

Pyrrolo[1,2-a]pyrazine-2(1H)-acetic acid, 3-(4-aminobutyl)hexahydro-1,4-dioxo-α-(2-phenylethyl)-, (αS,3S,8aR)-

Lisinopril EP Impurity D (Lisinopril (S,S,R)-Diketopiperazine)

Lisinopril EP Impurity DQ: What is Lisinopril EP Impurity D Q: What is the CAS Number of Lisinopril EP Impurity D Q: What is the storage condition of Lisinopril EP Impurity D Q: What are the applications of Lisinopril EP Impurity D

LisinoprilEPImpurityDHCl-DiketopiperazineHCl)

Lisinopril specified impurity D

Lisinopril Dihydrate EP Impurity D

Lsinopril imp D

Lisinopril R,S,S-Diketopiperazine

(2S)-2-[(3S,8aR)-3-(4-Aminobutyl)-1,4-dioxohexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-4-phenylbutanoic

Lisinopril diketopipirazine

(2S)-2-[(3S,8aR)-3-(4-Aminobutyl)-1,4-dioxohexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-4-phenylbutanoic Acid (R,S,S-Diketopiperazine)

R,S,S-diketopiperazine (EP & USP)/Lisinopril EP Impurity D

219677-82-4

C21H29N3O4

Intermediates & Fine Chemicals

Metabolites & Impurities

Pharmaceuticals

Various Metabolites and Impurities