2,6-Difluoro-3-iodobenzoic acid
- Product Name
- 2,6-Difluoro-3-iodobenzoic acid
- CAS No.
- 229178-74-9
- Chemical Name
- 2,6-Difluoro-3-iodobenzoic acid
- Synonyms
- 3-Iodo-n-butylbenzene;2,6-Difluoro-3-iodobenzoic acid;Benzoic acid, 2,6-difluoro-3-iodo-
- CBNumber
- CB01177428
- Molecular Formula
- C7H3F2IO2
- Formula Weight
- 284
- MOL File
- 229178-74-9.mol
2,6-Difluoro-3-iodobenzoic acid Property
- Boiling point:
- 311.1±42.0 °C(Predicted)
- Density
- 2.144±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- pka
- 1.99±0.10(Predicted)
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2916399090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D448698
- Product name
- 2,6-Difluoro-3-iodobenzoicAcid
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- W4663
- Product name
- 2,6-Difluoro-3-iodobenzoicacid
- Packaging
- 250mg
- Price
- $87
- Updated
- 2021/12/16
- Product number
- PC446159
- Product name
- 2,6-Difluoro-3-iodobenzoicacid
- Purity
- 95+%
- Packaging
- 1g
- Price
- $87
- Updated
- 2021/12/16
- Product number
- PC446159
- Product name
- 2,6-Difluoro-3-iodobenzoicacid
- Purity
- 95+%
- Packaging
- 5g
- Price
- $182
- Updated
- 2021/12/16
- Product number
- HCH0360915
- Product name
- 2,6-DIFLUORO-3-IODOBENZOIC ACID
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $497.72
- Updated
- 2021/12/16
2,6-Difluoro-3-iodobenzoic acid Chemical Properties,Usage,Production
Synthesis
385-00-2
229178-74-9
N-Iodosuccinimide (NIS, 2.25 g, 10.0 mmol) was added batchwise to a solution of 2,6-difluorobenzoic acid (1.58 g, 10.0 mmol) in concentrated sulfuric acid (25 mL) at 0 °C. The reaction mixture was stirred continuously at 0°C for 3.5 hours. Subsequently, the mixture was slowly poured into crushed ice (10 g) and 3% sodium sulfite solution (10 mL) was added to quench the reaction. The resulting slurry was continued to be stirred at 0 °C for 1 h, after which the product was separated by filtration. The product was washed with water and dried to afford the target compound 2,6-difluoro-3-iodobenzoic acid (Compound 3) as a white solid (2.05 g, 72% yield). The structure of the product was confirmed by 1H NMR (CDCl3) δ 6.78-6.82 (t, 1H, J=8.4 Hz, ArH), 7.78-7.83 (m, 1H, ArH) and GC-MS (m/z: 240 [M-44]+).
References
[1] Journal of Medicinal Chemistry, 2009, vol. 52, # 15, p. 4869 - 4882
[2] Journal of Agricultural and Food Chemistry, 1999, vol. 47, # 8, p. 3416 - 3424
[3] Bioorganic and Medicinal Chemistry, 2011, vol. 19, # 16, p. 5039 - 5045
2,6-Difluoro-3-iodobenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,6-Difluoro-3-iodobenzoic acid manufacturers
- Product
- 2,6-Difluoro-3-iodobenzoic acid 229178-74-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-01-02