Alonimide Property

Melting point:

201-203 °C

Boiling point:

510.9±50.0 °C(Predicted)

Density 

1.33±0.1 g/cm3(Predicted)

pka

11.55±0.20(Predicted)

Hazard and Precautionary Statements (GHS)

Alonimide Chemical Properties,Usage,Production

Originator

Alonimide ,ZYF Pharm Chemical

Uses

Sedativehypnotic.

Manufacturing Process

To a stirred mixture of 58.6 g (0.5 M) of phenyl-acetonitrile and 150 g (1.5 M) of ethyl acrylate was carefully added sodium methoxide in small increments (about 0.1 g). The exothermic reaction was controlled by ice bath cooling to keep the reaction mixture at 50°C. When further additions of sodium methoxide were no longer exothermic, the reaction mixture was stirred for one half hour more and the excess ethyl acrylate removed under reduced pressure on a steam bath. The resulting oil was added to 1.500 g of polyphosphoric acid and stirred on a steam bath for three hours. After cooling to about 50°C, 0.5 liter of chloroform was added followed by additions of crushed ice until the aqueous phase was free flowing. The chloroform layer was separated and combined with three 150 ml chloroform extracts of the aqueous layer. The organic phase was then dried over anhydrous magnesium sulfate, filtered and concentrated to a semi-solid residue.
Recrystallization from acetone gave 2,3-dihydrospiro[naphthalene-1(4H),3'- piperidine]-2',4,6'-trione, melting point 197°-199°C.

Therapeutic Function

Sedative, Hypnotic