Benzolamide

Product Name: Benzolamide
CAS No.: 3368-13-6
Chemical Name: Benzolamide
Synonyms: W-1803;W 1803;Benzolamide;Benzolamide, 10 mM in DMSO;2-benzenesulfonamido-1,3,4-thiadiazole-5-sulfonamide;5-(Phenylsulfonamido)-1,3,4-thiadiazole-2-sulfonamide;5-(phenylsulfonylamino)-1,3,4-thiadiazole-2-sulfonamide;1,3,4-Thiadiazole-2-sulfonamide, 5-[(phenylsulfonyl)amino]-;Benzolamide,Inhibitor,Carbonate dehydratase,seizures,CAS3,glaucoma,inhibit,Carbonic Anhydrase
CBNumber: CB01178102
Molecular Formula: C8H8N4O4S3
Formula Weight: 320.37
MOL File: 3368-13-6.mol

More

Less

Benzolamide Property

Melting point:: 239.5°C (rough estimate)
Boiling point:: 585.9±33.0 °C(Predicted)
Density: 1.6772 (rough estimate)
refractive index: 1.5690 (estimate)
storage temp.: 4°C, protect from light
solubility: DMSO : 250 mg/mL (780.35 mM; Need ultrasonic)
form: Solid
pka: 4.42±0.40(Predicted)
color: White to light yellow
Water Solubility: 384.4mg/L(25 ºC)

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: INB0001810
Product name: BENZOLAMIDE
Purity: 95.00%
Packaging: 5MG
Price: $498.43
Updated: 2021/12/16

Crysdot

Product number: CD11141461
Product name: 5-(Phenylsulfonamido)-1,3,4-thiadiazole-2-sulfonamide
Purity: 97%
Packaging: 250mg
Price: $500
Updated: 2021/12/16

More

Less

Benzolamide Chemical Properties,Usage,Production

Uses

Benzolamide (CL11366) is a potent carbonic anhydrase (CA) inhibitor, with Kis of 15 nM, 9 nM, 94 nM and 78 nM for hCA I, hCA II, EcoCAγ and VchCAγ, respectively. Benzolamide also inhibits CAS3, with a Ki of 54 nM. Benzolamide can be used for the research of glaucoma and seizures[1][2][3].

in vivo

Benzolamide (90 μmol/kg; i.p.) decreases brain pH and suppresses electrographic post-asphyxia seizures in rats^[3].

Animal Model:	Male and female Wistar Han rats (11-day-old)^[3]
Dosage:	90 μmol/kg
Administration:	A single i.p.
Result:	Induced a fast brain acidosis of a comparable magnitude. Suppressed electrographic seizures after asphyxia by slowing down the recovery of brain pH.

IC 50

CA Ⅱ

References

[1] Prete SD, et, al. Escherichia coli γ-carbonic anhydrase: characterisation and effects of simple aromatic/heterocyclic sulphonamide inhibitors. J Enzyme Inhib Med Chem. 2020 Dec;35(1):1545-1554. DOI:10.1080/14756366.2020.1800670
[2] Vullo D, et, al. Sulfonamide Inhibition Studies of the β-Class Carbonic Anhydrase CAS3 from the Filamentous Ascomycete Sordaria macrospora. Molecules. 2020 Feb 25;25(5):1036. DOI:10.3390/molecules25051036
[3] Pospelov AS, et, al. Carbonic anhydrase inhibitors suppress seizures in a rat model of birth asphyxia. Epilepsia. 2021 Jun 27. DOI:10.1111/epi.16963

Benzolamide Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Benzolamide Suppliers

China 26 United States 1 Global 27

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66113011 17798518460
Fax: (1)02557626880
Email: cfzhang@aikonchem.com
Country: China
ProdList: 19913
Advantage: 55

Deyang Yuehe Bio-Pharmaceutical Co.,Ltd

Tel: 028-82729560 18030702676
Fax: 028-82729560
Email: sales@yuehepharm.com
Country: China
ProdList: 179
Advantage: 58

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Shanghai Kaiwei Chemical Technology Co., Ltd.

Tel: 021-58461859 15821823057
Email: service@aiviche.com
Country: China
ProdList: 49312
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
ProdList: 29757
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Country: China
ProdList: 59936
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

Zhengzhou Converging Chemical Co. LTD

Tel: 0371-53399770 18037166334
Email: 2853031800@qq.com
Country: China
ProdList: 5891
Advantage: 58

Jiaxing Deyi Chemical Co., Ltd

Tel: 0573-85866609 13588473046
Email: 824930988@qq.com
Country: China
ProdList: 7865
Advantage: 58

Shanghai Tachizaki Biomedical Research Center

Tel: 18014399201
Email: sales@chemlab-tachizaki.com
Country: China
ProdList: 2742
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 17801761073
Email: Gsiyu@solarbio.com
Country: China
ProdList: 50464
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 025-85560043 15850508050
Fax: 025-85563444
Email: cindy.huang@synzest.com
Country: China
ProdList: 12000
Advantage: 58

Changsha Fuzhen Biotechnology Co.，LTD

Tel: 0731-13823398 15111215862
Email: 313359644@qq.com
Country: China
ProdList: 4161
Advantage: 58

RD International Technology Co., Limited

Tel: 18024082417
Email: market@ubiochem.com
Country: China
ProdList: 9835
Advantage: 58

Shanghai Hansi Chemical Industry Co., Ltd.

Tel: 17717618050
Email: zllg@gh-reagent.com
Country: China
ProdList: 10420
Advantage: 58

nanjing

Tel: 13376082704 13376084917;
Email: 3930959291@qq.com
Country: China
ProdList: 2079
Advantage: 58

Sangon Biotech (Shanghai) Co.,Ltd.

Tel: 400-821-026
Email: Sales@sangon.com
Country: China
ProdList: 6710
Advantage: 58

ATK CHEMICAL COMPANY LIMITED

Tel: +undefined-21-51877795
Fax: +86 21 5161 9052/ 5187 7796
Email: ivan@atkchemical.com
Country: China
ProdList: 33024
Advantage: 60

Hangzhou MolCore BioPharmatech Co.,Ltd.

Tel: +86-057181025280; +8617767106207
Fax: 0571-85806285
Email: sales@molcore.com
Country: China
ProdList: 49734
Advantage: 58

Guangzhou Kati Biotechnology Co., Ltd.

Tel: 13128698830
Country: CHINA
ProdList: 199
Advantage: 58

Guangzhou Kangkaixin Biotechnology Co., Ltd.

Tel: 13760798286
Country: CHINA
ProdList: 188
Advantage: 58

Absin Bioscience Inc.

Tel: --
Fax: --
Email: chenjw@absin.cn
Country: CHINA
ProdList: 6208
Advantage: 58

Proteintech China

Tel: --
Fax: --
Email: Proteintech-CN@ptglab.com
Country: CHINA
ProdList: 6290
Advantage: 58

Lanospharma Laboratories Co.,Ltd

Tel: --
Fax: --
Email: sales@lanospharma.com
Country: China
ProdList: 6329
Advantage: 56

Qingdao Rainbow Bio-tech Co., Ltd.

Tel: --
Fax: --
Email: tanner@rainbow-biotech.com
Country: China
ProdList: 62
Advantage: 34

3368-13-6, BenzolamideRelated Search:

Fluconazole aniline 5-AMINO-1,3,4-THIADIAZOLE-2-SULFONAMIDE Benzolamide

5-(phenylsulfonylamino)-1,3,4-thiadiazole-2-sulfonamide

2-benzenesulfonamido-1,3,4-thiadiazole-5-sulfonamide

Benzolamide

1,3,4-Thiadiazole-2-sulfonamide, 5-[(phenylsulfonyl)amino]-

5-(Phenylsulfonamido)-1,3,4-thiadiazole-2-sulfonamide

W 1803

W-1803

Benzolamide,Inhibitor,Carbonate dehydratase,seizures,CAS3,glaucoma,inhibit,Carbonic Anhydrase

Benzolamide, 10 mM in DMSO

3368-13-6

C8H8N4O4S3