ChemicalBook > CAS DataBase List > Biphenyl-4-Ethanol

Biphenyl-4-Ethanol

Product Name: Biphenyl-4-Ethanol
CAS No.: 37729-18-3
Chemical Name: Biphenyl-4-Ethanol
Synonyms: Biphenyl-4-Ethanol;[1,1biphenyl]-4-ethanol;2-(4-Biphenylyl)ethanol;2-(biphenyl-4-yl)ethanol;2-([1,1'-Biphenyl]-4-yl);2-(4-phenylphenyl)ethanol;4-(2-Hydroxyethyl)biphenyl;2-([1,1'-Biphenyl]-4-yl)ethanol;2-[1,1'-Biphenyl]-4-yl-1-ethanol;2-(Biphenyl-4-yl)ethan-1-ol, 4-Phenylphenethyl alcohol
CBNumber: CB01178122
Molecular Formula: C14H14O
Formula Weight: 198.26
MOL File: 37729-18-3.mol

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Biphenyl-4-Ethanol Property

Melting point:: 93-94 °C
Boiling point:: 203-207 °C(Press: 17 Torr)
Density: 1.071±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 14.83±0.10(Predicted)
Appearance: Off-white to light yellow Solid
InChI: InChI=1S/C14H14O/c15-11-10-12-6-8-14(9-7-12)13-4-2-1-3-5-13/h1-9,15H,10-11H2
InChIKey: CLGLKAAXNFFWON-UHFFFAOYSA-N
SMILES: C1(C2=CC=CC=C2)=CC=C(CCO)C=C1

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Safety

HazardClass: IRRITANT
HS Code: 2906290090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Matrix Scientific

Product number: 048295
Product name: 2-[1,1'-Biphenyl]-4-yl-1-ethanol
Purity: >95%
Packaging: 500mg
Price: $112
Updated: 2021/12/16

Apolloscientific

Product number: OR16854
Product name: 4-(2-Hydroxyethyl)biphenyl
Packaging: 500mg
Price: $160
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2701-1-15
Product name: 4-(2-Hydroxyethyl)biphenyl
Packaging: 500mg
Price: $176
Updated: 2021/12/16

Matrix Scientific

Product number: 048295
Product name: 2-[1,1'-Biphenyl]-4-yl-1-ethanol
Purity: >95%
Packaging: 1g
Price: $200
Updated: 2021/12/16

Apolloscientific

Product number: OR16854
Product name: 4-(2-Hydroxyethyl)biphenyl
Packaging: 1g
Price: $211
Updated: 2021/12/16

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Biphenyl-4-Ethanol Chemical Properties,Usage,Production

Synthesis

5728-52-9

37729-18-3

Method 2: Sodium borohydride (1.2 g, 31.7 mmol) was added to a flask containing tetrahydrofuran (THF) (40 mL) under nitrogen protection and stirring was initiated. Subsequently, 4-biphenylacetic acid (5.0 g, 23.6 mmol) was added slowly over 20 min, maintaining the temperature of the reaction mixture at 20-30 °C. After adding THF rinse solution (5 mL), stirring was continued for 20 min. Next, a THF (10 mL) solution of iodine (2.9 g, 11.4 mmol) was added slowly and dropwise over about 1 hour while maintaining the reaction temperature at 20-30 °C. The reaction mixture continued to be stirred at this temperature for about 1 h until thin layer chromatography (TLC) analysis confirmed complete conversion of 4-biphenylacetic acid. Reaction quenching was achieved by addition of 5 wt% aqueous sodium hydroxide solution (26 mL). After thorough mixing, the solution was allowed to partition and the lower aqueous phase was discarded. The aqueous phase was extracted with isopropyl acetate (2 x 25 mL) and the organic phases were combined and washed with deionized water (4 x 20 mL). The organic phase was evaporated under reduced pressure to give 2-(biphenyl-4'-yl)ethanol as a light yellow crystalline solid (4.6 g, 98.5% yield). The product can also be purified by crystallization via solvent exchange of isopropyl acetate with heptane as described in Method 1.

References

[1] Bioorganic and Medicinal Chemistry, 2005, vol. 13, # 15, p. 4740 - 4749
[2] Patent: WO2008/48609, 2008, A1. Location in patent: Page/Page column 86
[3] Patent: WO2008/5338, 2008, A1. Location in patent: Page/Page column 101
[4] Patent: WO2008/48609, 2008, A1. Location in patent: Page/Page column 55
[5] Patent: WO2014/144836, 2014, A2. Location in patent: Paragraph 0519; 0520

Biphenyl-4-Ethanol Preparation Products And Raw materials

Raw materials

Preparation Products

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37729-18-3, Biphenyl-4-EthanolRelated Search:

Biphenyl-4-Ethanol

[1,1biphenyl]-4-ethanol

2-[1,1'-Biphenyl]-4-yl-1-ethanol

4-(2-Hydroxyethyl)biphenyl

2-(Biphenyl-4-yl)ethan-1-ol, 4-Phenylphenethyl alcohol

2-([1,1'-Biphenyl]-4-yl)

2-(biphenyl-4-yl)ethanol

2-([1,1'-Biphenyl]-4-yl)ethanol

2-(4-phenylphenyl)ethanol

2-(4-Biphenylyl)ethanol

37729-18-3

Benzene derivatives