Botiacrine Property

Boiling point:

450.2±55.0 °C(Predicted)

Density 

1.144±0.06 g/cm3(Predicted)

pka

8.46±0.28(Predicted)

Hazard and Precautionary Statements (GHS)

Botiacrine Chemical Properties,Usage,Production

Originator

Botiacrine,ZYF Pharm Chemical

Manufacturing Process

To 1 gramm-equivalent (g-eq) of dimethylaminoethanethiol in 150 ml of ether, a suspension of g-eq of 50% sodium hydride in 50-ml of anhydrous ether was added. After boiling for 1 hour, the reaction mixture was cooled to 0°C, whereupon g-eq of 9,9-dimethylacridan-10-carboxylic acid chloride (prepared from 9,9-dimethylacridan and phosghene - cf. Swiss Specification No. 426,821) were added and the mixture was heated for a further 6 hours to boiling temperature. After cooling to ambient temperature, the precipitated sodium chloride was filtered in a Buchner funnel fitted with a filter cell. The corresponding 9,9-dimethylacridan-10-carboxylic aciddimethylaminoethanethiol ester was immediately precipitated out of filtrate as base, which melted at 110.5°-111°C. Ethanesulphonic acid salt melted at 147°-150°C.

Therapeutic Function

Antiparkinsonian