Mitoguazone
- Product Name
- Mitoguazone
- CAS No.
- 459-86-9
- Chemical Name
- Mitoguazone
- Synonyms
- MGBG;Me-GAG;methyl-g;methyl-gag;Mitoguazone USP/EP/BP;Mitoguazone(Methyl-GAG);Methylglycoxali BisguanylhydrazonuM;Pyruvaldehyde bis(amidinohydrazone);1,1'-((methylethanediylidene)dinitrilo)diguanidine;1,1'-((methylethanediylidene)dinitrilo)di-guanidin
- CBNumber
- CB01179220
- Molecular Formula
- C5H12N8
- Formula Weight
- 184.2
- MOL File
- 459-86-9.mol
Mitoguazone Property
- Melting point:
- 225 °C (decomp)
- Boiling point:
- 323.8±25.0 °C(Predicted)
- Density
- 1.55±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Acetonitrile: Slightly Soluble: 0.1-1 mg/mL
Water: Sparingly Soluble: 1-10 mg/mL - form
- Solid
- pka
- 7.63, 9.05(at 25℃)
- color
- Light brown to brown
- Water Solubility
- Water: 50 mg/mL (271.44 mM; ultrasonic and adjust pH to 9 with HCl)
- CAS DataBase Reference
- 459-86-9
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- M373450
- Product name
- Mitoguazone
- Packaging
- 100mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- CS-0026193
- Product name
- Mitoguazone
- Purity
- 99.38%
- Packaging
- 5mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- CS-0026193
- Product name
- Mitoguazone
- Purity
- 99.38%
- Packaging
- 10mg
- Price
- $220
- Updated
- 2021/12/16
- Product number
- CS-0026193
- Product name
- Mitoguazone
- Purity
- 99.38%
- Packaging
- 50mg
- Price
- $610
- Updated
- 2021/12/16
Mitoguazone Chemical Properties,Usage,Production
Chemical Properties
White crystals, melting point 256-257℃ (decomposition). Very soluble in water, relatively stable in acidic water, unstable in alkaline medium.
Uses
Mitoguazone has therapeutic applications as a cytotoxic agent.
Definition
ChEBI: A hydrazone obtained by formal condensation of the two carbonyl groups of methylglyoxal with the primary amino groups of two molecules of aminoguanidine.
in vivo
The influence of different stages of leukemia P388 on the pharmacokinetics of the antineoplastic agent Mitoguazone in mice is investigated. Independent of the tumor stage investigated, the total clearance of mitoguazone is slightly reduced reflecting a moderate increase of AUC in the serum of leukemia-bearing animals. Furthermore, in an advanced tumor stage the drug levels in kidneys, liver, spleen and serum are found to be elevated to some extent in comparison to tumor-free controls in contrast to an earlier stage of leukemia[5].
References
[1] U REGENASS. CGP 48664, a new S-adenosylmethionine decarboxylase inhibitor with broad spectrum antiproliferative and antitumor activity.[J]. Cancer research, 1994, 54 12: 3210-3217.
[2] XIA JIN Hua X Michael S McGrath. Inhibition of HIV Expression and Integration in Macrophages by Methylglyoxal-Bis-Guanylhydrazone.[J]. Journal of Virology, 2015, 89 22: 11176-11189. DOI: 10.1128/jvi.01692-15
[3] F MIKLES-ROBERTSON C W P C Dave. Apparent autophagocytosis of mitochondria in L1210 leukemia cells treated in vitro with 4,4’-diacetyl-diphenylurea-bis(guanylhydrazone).[J]. Cancer research, 1980, 40 4: 1054-1061.
[4] SHIGERU FUJIMOTO. Antitumor effects of two polyamine antimetabolites combined with mitomycin C on human stomach cancer cells xenotransplanted into nude mice[J]. International Journal of Cancer, 1985, 35 6: 821-825. DOI: 10.1002/ijc.2910350620
Mitoguazone Preparation Products And Raw materials
Raw materials
Preparation Products
Mitoguazone Suppliers
- Tel
- 021-50182298 021-50180596
- Fax
- +86-21-57758967
- sales@boylechem.com
- Country
- China
- ProdList
- 2208
- Advantage
- 55
- Tel
- 1-(800)-881-8210
- Fax
- 615-250-9817
- inquiries@lgmpharma.com
- Country
- United States
- ProdList
- 2123
- Advantage
- 70
- Tel
- 025-83697070
- Fax
- +86-25-83453306
- info@chemlin.com.cn
- Country
- China
- ProdList
- 15883
- Advantage
- 64
- Tel
- 15527768836
- 1791901229@qq.com
- Country
- China
- ProdList
- 6950
- Advantage
- 52
- Tel
- 400-188-0725 +86 21 34310725 13611771617
- Fax
- +86 21 34311076
- Country
- China
- ProdList
- 2002
- Advantage
- 57
- Tel
- 025-57798810
- Fax
- 025-57019371
- sales@sunlidabio.com
- Country
- China
- ProdList
- 3239
- Advantage
- 55
- Tel
- 15221275939
- Fax
- 021-50706099
- shenlinxing@macklin.cn
- Country
- China
- ProdList
- 15873
- Advantage
- 55
- Tel
- 021-52996696，15000506266 15000506266
- Fax
- +86-21-52996696
- Country
- China
- ProdList
- 4757
- Advantage
- 55
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 71826
- Advantage
- 60
- Tel
- sales@njromanme.com
- Country
- China
- ProdList
- 4529
- Advantage
- 58
View Lastest Price from Mitoguazone manufacturers
- Product
- Mitoguazone 459-86-9
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-29
- Product
- Mitoguazone 459-86-9
- Price
- US $300.00-280.00/kg
- Min. Order
- 1kg
- Purity
- 99.5%(HPLC)
- Supply Ability
- 10 tons
- Release date
- 2023-08-16
- Product
- Mitoguazone
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-07-02