ChemicalBook > CAS DataBase List > BI-0474

BI-0474

Product Name
BI-0474
CAS No.
2750570-55-7
Chemical Name
BI-0474
Synonyms
BI-0474;Benzo[b]thiophene-3-carbonitrile, 2-amino-4-[3-[6-[(2S)-2,4-dimethyl-1-piperazinyl]-4-[4-(1-oxo-2-propen-1-yl)-1-piperazinyl]-2-pyridinyl]-1,2,4-oxadiazol-5-yl]-4,5,6,7-tetrahydro-4-methyl-, (4S)-
CBNumber
CB012245556
Molecular Formula
C30H37N9O2S
Formula Weight
587.74
MOL File
2750570-55-7.mol
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BI-0474 Property

Boiling point:
879.4±75.0 °C(Predicted)
Density 
1.38±0.1 g/cm3(Predicted)
pka
7.13±0.70(Predicted)
form 
Solid
color 
White to off-white
InChIKey
CKAMBYUZKWQCKJ-ADSBAMQRSA-N
SMILES
C12CCC[C@@](C3ON=C(C4=NC(N5CCN(C)C[C@@H]5C)=CC(N5CCN(C(=O)C=C)CC5)=C4)N=3)(C)C=1C(C#N)=C(N)S2
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Hazard and Precautionary Statements (GHS)

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BI-0474 Chemical Properties,Usage,Production

Description

BI-0474 is a potent KRASG12C inhibitor with an IC50 value of 7.0 nM.

Uses

BI-0474 is a potent KRASG12C inhibitor with an IC50 value of 7.0 nM for the GDP-KRAS::SOS1 protein-protein interaction. It exhibits good anti-proliferative activity against NCI-H358 cells carrying the G12C mutation. BI-0474 also shows good anti-tumour activity in non-small cell lung cancer xenograft models.

in vitro

BI-0474 (1-10,000 nM; 3 days) shows potent antiproliferative activity of 26 nM on NCI-H358 cells carrying a G12C mutation.

in vivo

BI-0474 (40 mg/kg; i.p.; single daily for 3 days) shows anti-tumor efficacy and pharmacodynamic biomarker modulation in an NCI-H358 cell line-derived non-small cell lung cancer xenograft model

BI-0474 Preparation Products And Raw materials

Raw materials

Preparation Products

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BI-0474 Suppliers

China 29 United States 1 Global 30
Hubei Chuchang Chemical Co., Ltd
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18; 15623560702
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China
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Changzhou Borl Biotechnology Co.,LTD
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luyan0021@163.com
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ShangHai Caerulum Pharma Discovery Co., Ltd.
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18149758185 18149758185
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sales-cpd@caerulumpharma.com
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Shanghai Lollane Biological Technology Co.,Ltd.
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021-52996696，15000506266 15000506266
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+86-21-52996696
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ShangHai Angti Biotechnology Co., Ltd.
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13764913901
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info@angtibio.com
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ShangHai Biochempartner Co.,Ltd
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Bide Pharmatech Ltd.
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InvivoChem
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TargetMol Chemicals Inc.
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Shanghai Tachizaki Biomedical Research Center
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Olix (Shanghai) Pharmaceutical Technology Co., Ltd
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Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd.
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Chengdu Peter-like Biotechnology Co., Ltd.
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Hubei Chuchang Biotech Co., Ltd.
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Absin Bioscience Inc.
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View Lastest Price from BI-0474 manufacturers

Hubei Chuchang Biotech Co., Ltd.
Product
BI-0474 2750570-55-7
Price
US $0.00-0.00/mg
Min. Order
5mg
Purity
98%+ HPLC HNMR
Supply Ability
10g
Release date
2024-04-17

2750570-55-7, BI-0474Related Search:


  • Benzo[b]thiophene-3-carbonitrile, 2-amino-4-[3-[6-[(2S)-2,4-dimethyl-1-piperazinyl]-4-[4-(1-oxo-2-propen-1-yl)-1-piperazinyl]-2-pyridinyl]-1,2,4-oxadiazol-5-yl]-4,5,6,7-tetrahydro-4-methyl-, (4S)-
  • BI-0474
  • 2750570-55-7
  • C30H37N9O2S