N-(2-methyl-1-oxobutyl)-Glycine
- Product Name
- N-(2-methyl-1-oxobutyl)-Glycine
- CAS No.
- 52320-67-9
- Chemical Name
- N-(2-methyl-1-oxobutyl)-Glycine
- Synonyms
- N-sec-Valerylglycine;2-Methylbutyrylglycine;α-Methylbutyrylglycine;2-Methylbutyroyl glycine;N-(2-Methylbutyryl)glycine;N-(2-methylbutanoyl)glycine;N-(2-methyl-1-oxobutyl)-Glycine;2-(2-Methylbutanamido)acetic acid;Glycine, N-(2-methyl-1-oxobutyl)-
- CBNumber
- CB01235421
- Molecular Formula
- C7H13NO3
- Formula Weight
- 159.18
- MOL File
- 52320-67-9.mol
N-(2-methyl-1-oxobutyl)-Glycine Property
- Melting point:
- 115-116°C
- Boiling point:
- 371.8±25.0 °C(Predicted)
- Density
- 1.097±0.06 g/cm3(Predicted)
- storage temp.
- Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 3.61±0.10(Predicted)
- color
- White to Off-White
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 283342
- Product name
- 2-Methylbutyrylglycine
- Packaging
- 500mg
- Price
- $460
- Updated
- 2021/12/16
- Product number
- M294340
- Product name
- 2-Methylbutyrylglycine
- Packaging
- 2g
- Price
- $485
- Updated
- 2021/12/16
- Product number
- M294340
- Product name
- 2-Methylbutyrylglycine
- Packaging
- 250mg
- Price
- $135
- Updated
- 2021/12/16
- Product number
- M294340
- Product name
- 2-Methylbutyrylglycine
- Packaging
- 10g
- Price
- $1755
- Updated
- 2021/12/16
- Product number
- 2383CB
- Product name
- 2-Methylbutyrylglycine
- Packaging
- 100mg
- Price
- $172
- Updated
- 2021/12/16
N-(2-methyl-1-oxobutyl)-Glycine Chemical Properties,Usage,Production
Uses
2-Methylbutyrylglycine is one of the acylglycines, an important class of metabolites that have been used in the diagnosis of several “inborn errors of metabolism” (IEM).
Definition
ChEBI: A N-acylglycine that is glycine substituted by a 2-methylbutanoyl group at the N atom.
Biological Activity
2-Methylbutyrylglycine is an acyl glycine. Acyl glycines are normally minor metabolites of fatty acids. However, the excretion of certain acyl glycines is increased in several inborn errors of metabolism. In certain cases the measurement of these metabolites in body fluids can be used to diagnose disorders associated with mitochondrial fatty acid beta-oxidation. Acyl glycines are produced through the action of glycine N-acyltransferase (EC 2.3.1.13) which is an enzyme th at catalyzes the chemical reaction:. acyl-CoA + glycine ↔ CoA + N-acylglycine. The isolated excretion of high levels of 2-methylbutyrylglycine (2-MBG) is the hallmark of short/branched-chain acyl-CoA dehydrogenase deficiency or SBCADD. The disorder is also called 2-methylbutyryl-CoA dehydrogenase deficiency and has been associated with autism and mental retardation. SBCADD is a recently described autosomal recessive disorder caused by a defect in the degradation pathway of L- isoleucine leading to increased urinary excretion of 2-methylbutyryl glycine. The enzymatic defect results from disruption of the SBCAD gene. Deficiency of SBCAD leads to accumulation of its substrate, 2-methylbutyryl-CoA within the mitochondrion. This substance is transesterified with glycine by the mitochondrial enzyme acyl-CoA glycine-N-acyltransferase (glycine-N-acylase) to form 2-methylbutyryl glycine. Affected patients can be divided into two categories. The first category consists of infants detected by newborn screening programs. These infants are treated with diet and remain without clinical symptoms. In the second category affected patients are diagnosed because they presented clinically with seizures and psychomotor delay and have increased urinary excretion of 2-methylbutyryl glycine. 2-Methylbutyrylglycine has also been found in the urine of patients with propionyl-CoA carboxylase deficiency after consuming isoleucine. 2-methylbutyrylglycine is also elevated in the urine of patients with glutaric aciduria II and ethylmalonic encephalopathy.
N-(2-methyl-1-oxobutyl)-Glycine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from N-(2-methyl-1-oxobutyl)-Glycine manufacturers
- Product
- N-(2-methyl-1-oxobutyl)-Glycine 52320-67-9
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2018-08-20