(3a,5b,7a,12a)-3,7,12-trihydroxy-Cholestan-26-oic acid

Product Name: (3a,5b,7a,12a)-3,7,12-trihydroxy-Cholestan-26-oic acid
CAS No.: 547-98-8
Chemical Name: (3a,5b,7a,12a)-3,7,12-trihydroxy-Cholestan-26-oic acid
Synonyms: THCA;Coprocholic acid;Trihydroxycholestanoic acid;3α,7α,12α-Trihydroxycoprostanic Acid;3α,7α,12α-Trihydroxycoprostanoic acid;3,7,12-trihydroxycholestan-26-oic acid;3α,7α,12α-trihydroxy cholestanoic acid;3α,7α,12α-Trihydroxy-5β-cholestanoic acid;3α,7α,12α-Trihydroxy-5β-cholestan-27-oic acid;3α,7α,12α-Trihydroxy-5β-cholestan-26-oic acid
CBNumber: CB01235764
Molecular Formula: C27H46O5
Formula Weight: 450.65
MOL File: 547-98-8.mol

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(3a,5b,7a,12a)-3,7,12-trihydroxy-Cholestan-26-oic acid Property

storage temp.: -20°C
solubility: Chloroform (Slightly, Heated), DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly)
form: Solid
color: White to Off-White

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 26098
Product name: Trihydroxycholestanoic Acid
Packaging: 500μg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 26098
Product name: Trihydroxycholestanoic Acid
Packaging: 5mg
Price: $302
Updated: 2024/03/01

Cayman Chemical

Product number: 26098
Product name: Trihydroxycholestanoic Acid
Packaging: 1mg
Price: $130
Updated: 2024/03/01

AK Scientific

Product number: 8684CA
Product name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestan-26-oicacid
Packaging: 1mg
Price: $241
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: LIP0002925
Product name: 3-ALPHA-7-ALPHA-12-ALPHA-TRIHYDROXYCHOLESTANOIC ACID
Purity: 95.00%
Packaging: 5MG
Price: $502.14
Updated: 2021/12/16

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(3a,5b,7a,12a)-3,7,12-trihydroxy-Cholestan-26-oic acid Chemical Properties,Usage,Production

Uses

3α,7α,12α-Trihydroxycoprostanic Acid is a precursor of Cholic Acid (C432600), it undergoes side chain oxidation during the synthesis of bile acids. It was found that Zellweger’s syndrome patients have abnormal mitochondrial structure, the organelle that is responsible for the side chain oxidation, and as a consequence, excess amounts of 3α,7α,12α-Trihydroxycoprostanic Acid.

Definition

ChEBI: A steroid acid that is 5beta-cholestan-26-oic acid which is substituted by hydroxy groups as the 3alpha, 7alpha, and 12alpha positions.

General Description

Trihydroxycholestanoic acid (THCA) is an oxidative metabolite of cholesterol and a precursor to bile acids. Very long-chain acyl-CoA synthetase (VLCS) associated with endoplasmic reticulum and peroxisomes activates THCA, the C27 bile acid intermediate.

Biochem/physiol Actions

Trihydroxycholestanoic acid (THCA) and dihydroxycholestanoic (DHCA) accumulation is observed in Zellweger syndrome and cholestatic liver disease. The synthesis of (25R)-isomer of DHCA and THCA is favored by mitochondrial 27-hydroxylase.

(3a,5b,7a,12a)-3,7,12-trihydroxy-Cholestan-26-oic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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(3a,5b,7a,12a)-3,7,12-trihydroxy-Cholestan-26-oic acid Suppliers

China 8 India 1 United States 2 Global 11

ChemStrong Scientific Co.,Ltd

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Sigma-Aldrich

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Alfa Chemistry

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TargetMol Chemicals Inc.

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Shanghai Yifei Biotechnology Co. , Ltd.

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SHANGHAI ZZBIO CO., LTD.

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547-98-8, (3a,5b,7a,12a)-3,7,12-trihydroxy-Cholestan-26-oic acidRelated Search:

COPROSTANE

(3a,5b,7a,12a)-3,7,12-trihydroxy-Cholestan-26-oic acid

3α,7α,12α-Trihydroxy-5β-cholestan-26-oic acid

3α,7α,12α-Trihydroxy-5β-cholestan-27-oic acid

3α,7α,12α-Trihydroxy-5β-cholestanoic acid

3α,7α,12α-Trihydroxycoprostanoic acid

THCA

Trihydroxycholestanoic acid

3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oic acid

Coprocholic acid

3,7,12-trihydroxycholestan-26-oic acid

Cholestan-26-oic acid, 3,7,12-trihydroxy-, (3α,5β,7α,12α)-

3α,7α,12α-Trihydroxycoprostanic Acid

3α,7α,12α-trihydroxy cholestanoic acid

547-98-8