DHEA-S
- Product Name
- DHEA-S
- CAS No.
- 651-48-9
- Chemical Name
- DHEA-S
- Synonyms
- PB005;PB 005;PB-005;DHEA-S;DHEA-ST;Prasterone sulfate;Formylisoglutamic acid;Abiraterone Impurity 54;Abiraterone Impurity 73;DEHYDROEPIANDROSTERONESULPHATE
- CBNumber
- CB01235906
- Molecular Formula
- C19H28O5S
- Formula Weight
- 368.49
- MOL File
- 651-48-9.mol
DHEA-S Property
- Boiling point:
- 468.81°C (rough estimate)
- Density
- 1.1763 (rough estimate)
- refractive index
- 1.5300 (estimate)
- Melting point:
- 190-192 °C
- pka
- -3.51±0.18(Predicted)
- form
- Solid
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- SHG0005097
- Product name
- DEHYDROEPIANDROSTERONE SULFATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $499.49
- Updated
- 2021/12/16
DHEA-S Chemical Properties,Usage,Production
Uses
Dehydroepiandrosterone sulfate, a neuroactive neurosteroid, plays a major role in brain development and aging by influencing the migration of neurons, arborization of dendrites, and formation of new synapses[1][2][3].
Definition
ChEBI: A steroid sulfate that is the 3-sulfooxy derivative of dehydroepiandrosterone.
in vivo
DHEAS chronic administration produces a dose-dependent effect on performance[3].
| Animal Model: | Sixty-four male Sprague-Dawley rats, approximately 90 days of age (300-400 g)[3]. |
| Dosage: | 5, 10, or 20 mg/kg. |
| Administration: | Subcutaneous injection starting 7 days post-surgery and 1 h prior to all behavioral testing. |
| Result: | Significantly effective in improving latency to reach the platform as compared to injured rats receiving vehicle. |
IC 50
Human Endogenous Metabolite
References
[1] E E Baulieu, et al. Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) as neuroactive neurosteroids. Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4089-91. DOI:10.1073/pnas.95.8.4089
[2] C R Parker Jr, et al. Dehydroepiandrosterone and dehydroepiandrosterone sulfate production in the human adrenal during development and aging. Steroids. 1999 Sep;64(9):640-7. DOI:10.1016/s0039-128x(99)00046-x
[3] Stuart W Hoffman, et al. The delayed administration of dehydroepiandrosterone sulfate improves recovery of function after traumatic brain injury in rats. J Neurotrauma. 2003 Sep;20(9):859-70. DOI:10.1089/089771503322385791
DHEA-S Preparation Products And Raw materials
Raw materials
Preparation Products
DHEA-S Suppliers
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32435
- Advantage
- 58
- Tel
- tp@aladdinsci.com
- Country
- United States
- ProdList
- 57505
- Advantage
- 58
- Tel
- 1-516-855-7709
- Fax
- 1-631-938-8127
- info@creative-enzymes.com
- Country
- United States
- ProdList
- 8748
- Advantage
- 58
- Tel
- --
- Fax
- --
- info@creative-enzymes.com
- Country
- United States
- ProdList
- 6057
- Advantage
- 58