ChemicalBook > CAS DataBase List > Ethyl 2,6-dichloroisonicotinate

Ethyl 2,6-dichloroisonicotinate

Product Name: Ethyl 2,6-dichloroisonicotinate
CAS No.: 1604-14-4
Chemical Name: Ethyl 2,6-dichloroisonicotinate
Synonyms: Ethyl 2,6-dichloroisonicotinate;2,6-dichloroisonicotin ethyl ester;Ethyl 2,6-dichloropyridine-4-carboxylate;2,6-Dichloroisonicotinic acid ethyl ester;2,6-Dichloropyridine-4-carboxylic acid ethyl ester;4-Pyridinecarboxylic acid, 2,6-dichloro-, ethyl ester;4-Pyridinecarboxylic acid, 2,6-dichloro-, ethyl ester (9CI, ACI)
CBNumber: CB01247701
Molecular Formula: C8H7Cl2NO2
Formula Weight: 220.05
MOL File: 1604-14-4.mol

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Ethyl 2,6-dichloroisonicotinate Property

Melting point:: 67 °C
Boiling point:: 311.4±37.0 °C(Predicted)
Density: 1.367±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -4.27±0.10(Predicted)
Appearance: White to yellow Solid

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Safety

HazardClass: IRRITANT
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: D439895
Product name: 2,6-Dichloro-isonicotinicAcidethylester
Packaging: 10mg
Price: $45
Updated: 2021/12/16

AK Scientific

Product number: Z0236
Product name: Ethyl2,6-dichloroisonicotinate
Packaging: 10g
Price: $226
Updated: 2021/12/16

Apolloscientific

Product number: OR346276
Product name: 2,6-Dichloro-isonicotinicacidethylester
Packaging: 1g
Price: $264
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H58-5-2N
Product name: 2,6-Dichloroisonicotinic acid ethyl ester
Packaging: 1g
Price: $292
Updated: 2021/12/16

Matrix Scientific

Product number: 058969
Product name: 2,6-Dichloro-isonicotinic acid ethyl ester
Purity: 95+%
Packaging: 1g
Price: $439
Updated: 2021/12/16

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Ethyl 2,6-dichloroisonicotinate Chemical Properties,Usage,Production

Synthesis Reference(s)

Journal of Medicinal Chemistry, 45, p. 2484, 2002 DOI: 10.1021/jm0200660

Synthesis

64-17-5

5398-44-7

1604-14-4

To an ice-cold solution of 2,6-dichloroisonicotinic acid (10 g, 52 mmol) in ethanol (100 mL) was slowly added concentrated sulfuric acid (5 mL). The reaction mixture was heated to reflux and held for 12 hours. Upon completion of the reaction, the solvent was evaporated under reduced pressure. The residue was cooled in an ice bath, neutralized to pH neutral with sodium bicarbonate solution and subsequently extracted with ethyl acetate. The organic layers were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give ethyl 2,6-dichloro-isonicotinate (11 g, 96% yield).

References

[1] Patent: WO2017/4609, 2017, A1. Location in patent: Paragraph 0265
[2] Chemistry - A European Journal, 2010, vol. 16, # 9, p. 2830 - 2842
[3] Journal of the Chemical Society, 1897, vol. 71, p. 1082
[4] Journal of the Chemical Society, 1898, vol. 73, p. 441
[5] Journal of Medicinal Chemistry, 1990, vol. 33, # 6, p. 1667 - 1675

Ethyl 2,6-dichloroisonicotinate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Ethyl 2,6-dichloroisonicotinate manufacturers

Career Henan Chemical Co

Product: Ethyl 2,6-dichloroisonicotinate 1604-14-4
Price: US $6.68/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 1kg-1000kg
Release date: 2020-01-08

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