ChemicalBook > CAS DataBase List > Frova

Frova

Product Name: Frova
CAS No.: 158930-17-7
Chemical Name: Frova
Synonyms: Frova;Migard;Miguard;Frovelan;Unii-D28J6W18hy;Frova，Frovatriptan Succinate;Frovatriptan succinate [usan];Frovatriptan (succinate salt);Frovatriptan succinate hydrate;Frovatriptan Succinate (1286413)
CBNumber: CB01247842
Molecular Formula: C18H25N3O6
Formula Weight: 0
MOL File: 158930-17-7.mol

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Frova Property

Melting point:: 150-153°C
storage temp.: 2-8°C
solubility: DMSO (Slightly), Methanol (Slightly, Heated), Water (Slightly, Heated)
form: powder
color: white to beige
Water Solubility: H2O: 20mg/mL, clear
CAS DataBase Reference: 158930-17-7

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Safety

HS Code: 2933995500

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

H332Harmful if inhaled

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P281Use personal protective equipment as required.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1291
Product name: Frovatriptan succinate monohydrate
Purity: ≥97% (HPLC)
Packaging: 10MG
Price: $95
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML1291
Product name: Frovatriptan succinate monohydrate
Purity: ≥97% (HPLC)
Packaging: 50MG
Price: $393
Updated: 2025/07/31

Sigma-Aldrich

Product number: 1286413
Product name: Frovatriptan succinate
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 200MG
Price: $3610
Updated: 2025/07/31

Cayman Chemical

Product number: 23771
Product name: Frovatriptan (succinate hydrate)
Packaging: 5mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 23771
Product name: Frovatriptan (succinate hydrate)
Packaging: 10mg
Price: $100
Updated: 2024/03/01

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Frova Chemical Properties,Usage,Production

Chemical Properties

White to Off-White Powder

Uses

Serotonin 5-HT1B/1D receptor agonist. It is a triptan drug for the treatment of migraine headaches. Frovatriptan causes vasoconstriction of arteries and veins that supply blood to the head.

brand name

Frova (Endo).

Biochem/physiol Actions

Frovatriptan is a serotonin 5HT-1B/1D-receptor agonist used to treat migraine. Frovatriptan has high affinity for the 5-HT(1B) and 5-HT(1D) receptors while affinity for 5-HT receptors other than 5-HT(1B/1D) is substantially lower with a pEC50 value of 8.2 for the 5-HT1B receptor, compared to a pEC50 value of 6.2 for the 5-HT7 receptor.

in vivo

Oral bioavailability of Frovatriptan is 22%-30% and is not affected by food. Although the maximum concentration in the plasma is achieved in 2-3 hours, 60%-70% of this is achieved in 1 hour. A steady state is achieved in 4-5 days. Plasma protein binding is low at 15%. The most unique feature is the relative terminal long half-life of about 26 hours. Frovatriptan is chiefly metabolized by CYP1A2 and is cleared by the kidney and liver making moderate failure of either organ not a limiting factor in treatment^[1].
Frovatriptan (0.1, 0.2, and 0.3 mg/kg; a single bolus intraduodenal administration) treatment produces an increase in carotid vascular resistance, which is sustained for at least 5 hours in dogs^[2].

IC 50

5-HT_1B Receptor: 8.2 (pEC₅₀); 5-HT_1D Receptor

Frova Preparation Products And Raw materials

Raw materials

Preparation Products

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Frova Suppliers

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View Lastest Price from Frova manufacturers

Career Henan Chemical Co

Product: Frova 158930-17-7
Price: US $1.80/KG
Min. Order: 1g
Purity: 90.0%-99.9%
Supply Ability: 800kg
Release date: 2020-03-20

158930-17-7, FrovaRelated Search:

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Frovatriptan Succinate hydrateQ: What is Frovatriptan Succinate hydrate Q: What is the CAS Number of Frovatriptan Succinate hydrate Q: What is the storage condition of Frovatriptan Succinate hydrate Q: What are the applications of Frovatriptan Succinate hydrate

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Frova，Frovatriptan Succinate

Serotonin Receptor,5-HT1D,5-HT Receptor,Frovatriptan succinate hydrate,orally,Inhibitor,SB 209509 succinate,menstrual,Frovatriptan succinate,(R)-Frovatriptan succinate,inhibit,5-HT7,5-hydroxytryptamine Receptor,vomiting,carotid,migraine,5-HT1B,VML 251 succinate,photophobia,phonophobia,vascular,nausea

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158930-17-7

C14H17N3OC4H6O4H2O

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