ChemicalBook > CAS DataBase List > 1-[(3S,8S,9S,10R,13R,14S,17S)-3-methoxy-10,13-dimethyl-2,3,4,7,8,9,11, 12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone
1-[(3S,8S,9S,10R,13R,14S,17S)-3-methoxy-10,13-dimethyl-2,3,4,7,8,9,11, 12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone
- Product Name
- 1-[(3S,8S,9S,10R,13R,14S,17S)-3-methoxy-10,13-dimethyl-2,3,4,7,8,9,11, 12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone
- CAS No.
- 511-26-2
- Chemical Name
- 1-[(3S,8S,9S,10R,13R,14S,17S)-3-methoxy-10,13-dimethyl-2,3,4,7,8,9,11, 12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone
- Synonyms
- MAP4343;Pregn-5-en-20-one, 3-methoxy-, (3β)-;5-Pregnen-3B-ol-20-one-17a,21,21,21-d4 3-Methyl Ether;1-[(3S,8S,9S,10R,13R,14S,17S)-3-methoxy-10,13-dimethyl-2,3,4,7,8,9,11, 12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone;inhibit,microtubule-associated,Microtubule/Tubulin,Pregnenolone,MAP2,tubulin,polymerization,neurites,MAP 4343,MAP4343,Inhibitor,MAP-4343,protein
- CBNumber
- CB01260975
- Molecular Formula
- C22H34O2
- Formula Weight
- 330.5
- MOL File
- 511-26-2.mol
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1-[(3S,8S,9S,10R,13R,14S,17S)-3-methoxy-10,13-dimethyl-2,3,4,7,8,9,11, 12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone Property
- Melting point:
- 123.5°
- alpha
- D18 +18° (c = 1.085 in chloroform)
- Boiling point:
- 426.6±45.0 °C(Predicted)
- Density
- 1.04±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 25 mg/mL (75.64 mM)
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N-Bromosuccinimide Price
ChemScene
- Product number
- CS-0027351
- Product name
- MAP4343
- Packaging
- 5mg
- Price
- $100
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0027351
- Product name
- MAP4343
- Packaging
- 10mg
- Price
- $170
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0027351
- Product name
- MAP4343
- Packaging
- 25mg
- Price
- $350
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- API0016445
- Product name
- PREGNENOLONE METHYL ETHER
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $499.04
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0027351
- Product name
- MAP4343
- Packaging
- 100mg
- Price
- $900
- Updated
- 2021/12/16
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1-[(3S,8S,9S,10R,13R,14S,17S)-3-methoxy-10,13-dimethyl-2,3,4,7,8,9,11, 12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone Chemical Properties,Usage,Production
Biological Activity
MAP4343 is a 3-methyl ether derivative of Pregnenolone. It binds to microtubule-associated protein 2 (MAP2) in vitro, stimulates the polymerization of tubulin, enhances neurite extension and protects neurons from neurotoxic agents.
in vitro
MAP4343 (40 μM; 15 or 30 min) stimulates microtubule polymerization in vitro. It stimulates nerve growth factor (NGF)-induced neurite outgrowth in PC12 cells.
in vivo
MAP4343 (12 mg/kg; daily sc for 28 d) improves the recovery of locomotor function after spinal cord injury (SCI) in rats.
MAP4343 (4 mg/kg; daily sc for 6 d) increases MAP2 levels in spinal cord after SCI in rats.
MAP4343 (4 mg/kg; daily sc for 6 d) increases the size of lumbar spinal motoneurons' dendrite arbours after SCI in rats.
| Animal Model: | Adult Sprague-Dawley male rats with spinal cord injury |
| Dosage: | 12 mg/kg |
| Administration: | Daily sc for 28 days |
| Result: | Increased the number of animals able to walk with weight-supported plantar steps. Showed forelimb-hindlimb coordination at the end of the study. |
1-[(3S,8S,9S,10R,13R,14S,17S)-3-methoxy-10,13-dimethyl-2,3,4,7,8,9,11, 12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone Preparation Products And Raw materials
Raw materials
Preparation Products
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