2-Bromo-3-hydroxybenzaldehyde
- Product Name
- 2-Bromo-3-hydroxybenzaldehyde
- CAS No.
- 196081-71-7
- Chemical Name
- 2-Bromo-3-hydroxybenzaldehyde
- Synonyms
- 2-BROMO-3-HYDROXYBENZOIC ACID;B90006;2-Bromo-3-formylphenol;2-Bromo-3-hydroxybenzaL;Crisaborole Impurity 101;Benzaldehyde, 2-broMo-3-hydroxy-;2-BroMo-3-hydroxybenzaldehyde, 95+%
- CBNumber
- CB01262429
- Molecular Formula
- C7H5BrO2
- Formula Weight
- 201.02
- MOL File
- 196081-71-7.mol
2-Bromo-3-hydroxybenzaldehyde Property
- Melting point:
- 147-148℃
- Boiling point:
- 252℃
- Density
- 1.737
- Flash point:
- 106℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- DMSO (Slightly), Ethyl Acetate (Slightly)
- form
- Solid
- pka
- 7.71±0.10(Predicted)
- color
- Off-White to Pale Beige
- InChI
- InChI=1S/C7H5BrO2/c8-7-5(4-9)2-1-3-6(7)10/h1-4,10H
- InChIKey
- OHXPHMPERMIICA-UHFFFAOYSA-N
- SMILES
- C(=O)C1=CC=CC(O)=C1Br
Safety
- Hazard Codes
- Xi
- HS Code
- 2913000090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- B684705
- Product name
- 2-Bromo-3-hydroxybenzaldehyde
- Packaging
- 50mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- B684705
- Product name
- 2-Bromo-3-hydroxybenzaldehyde
- Packaging
- 100mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- B684705
- Product name
- 2-Bromo-3-hydroxybenzaldehyde
- Packaging
- 5g
- Price
- $180
- Updated
- 2021/12/16
- Product number
- B1244
- Product name
- 2-Bromo-3-hydroxybenzaldehyde
- Purity
- 97%
- Packaging
- 1g
- Price
- $12
- Updated
- 2021/12/16
- Product number
- J94161
- Product name
- 2-Bromo-3-hydroxybenzaldehyde
- Packaging
- 1g
- Price
- $15
- Updated
- 2021/12/16
2-Bromo-3-hydroxybenzaldehyde Chemical Properties,Usage,Production
Chemical Properties
Yellow Solid
Uses
2-Bromo-3-hydroxybenzaldehyde is a reactant used in the preparation of a class of benzoxaboroles antimalarial agents.
Synthesis
100-83-4
196081-71-7
The general procedure for the synthesis of 2-bromo-3-hydroxybenzaldehyde from m-hydroxybenzaldehyde was as follows: 3-hydroxybenzaldehyde (5 g, 0.04 mol), iron powder (172 mg, 3 mmol), and sodium acetate (6.72 g, 0.08 mol) were suspended in acetic acid (40 mL), warmed until a clarified solution was formed, and subsequently cooled to room temperature. A glacial acetic acid solution of bromine (10 mL) was slowly added dropwise to the mixture over 15 minutes. After the dropwise addition was completed, stirring of the reaction mixture was continued for 2 hours. Upon completion of the reaction, the mixture was poured into ice water and extracted with dichloromethane (3 x 50 mL). The organic phases were combined, dried over anhydrous Na2SO4 and concentrated. The residue was recrystallized by dichloromethane to afford the target product 2-bromo-3-hydroxybenzaldehyde (2.3 g, 28% yield). The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 10.30 (s, 1H), 7.54-7.51 (m, 1H), 7.39-7.35 (m, 1H), 7.31-7.27 (m, 1H), 5.90 (s, 1H).
References
[1] European Journal of Organic Chemistry, 2007, # 34, p. 5726 - 5733
[2] Patent: WO2012/33858, 2012, A2. Location in patent: Page/Page column 76
[3] Patent: WO2015/21396, 2015, A2. Location in patent: Paragraph 00121-00122
[4] Organic Letters, 2016, vol. 18, # 21, p. 5656 - 5659
2-Bromo-3-hydroxybenzaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
2-Bromo-3-hydroxybenzaldehyde Suppliers
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- Country
- United Kingdom
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View Lastest Price from 2-Bromo-3-hydroxybenzaldehyde manufacturers
- Product
- 2-Bromo-3-hydroxybenzaldehyde 196081-71-7
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1TON
- Release date
- 2023-02-15
- Product
- 2-Bromo-3-hydroxybenzaldehyde 196081-71-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2019-12-24