3-CHLORO-5-HYDROXY-BENZOIC ACID
- Product Name
- 3-CHLORO-5-HYDROXY-BENZOIC ACID
- CAS No.
- 53984-36-4
- Chemical Name
- 3-CHLORO-5-HYDROXY-BENZOIC ACID
- Synonyms
- 3-chloro-5-hydroxy BA;GPR81 Agonist, 3Cl-5OH-BA;5-Chloro-m-salicylic Acid;3-CHLORO-5-HYDROXY-BENZOIC ACID;5-(hydroxy)-3-chlorobenzoic acid;Benzoic acid, 3-chloro-5-hydroxy-;GPR81 Agonist, 3Cl-5OH-BA - CAS 53984-36-4 - Calbiochem
- CBNumber
- CB0129376
- Molecular Formula
- C7H5ClO3
- Formula Weight
- 172.57
- MOL File
- 53984-36-4.mol
3-CHLORO-5-HYDROXY-BENZOIC ACID Property
- Melting point:
- 244.0 to 248.0 °C
- Boiling point:
- 364.8±27.0 °C(Predicted)
- Density
- 1.536±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO: soluble15mg/mL (clear solution)
- pka
- 3.71±0.10(Predicted)
- form
- powder
- color
- white to beige
- InChIKey
- RJOLIYHZZKAIET-UHFFFAOYSA-N
- CAS DataBase Reference
- 53984-36-4
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-37/38-41
- Safety Statements
- 26-36
- WGK Germany
- 3
- HS Code
- 2916399090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML0447
- Product name
- 3-Chloro-5-hydroxybenzoic acid
- Purity
- ≥97% (HPLC)
- Packaging
- 25mg
- Price
- $309
- Updated
- 2023/01/07
- Product number
- C3183
- Product name
- 3-Chloro-5-hydroxybenzoic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $116
- Updated
- 2024/03/01
- Product number
- C3183
- Product name
- 3-Chloro-5-hydroxybenzoic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $391
- Updated
- 2024/03/01
- Product number
- 16795
- Product name
- 3-chloro-5-hydroxy BA
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $36
- Updated
- 2024/03/01
- Product number
- 16795
- Product name
- 3-chloro-5-hydroxy BA
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $61
- Updated
- 2024/03/01
3-CHLORO-5-HYDROXY-BENZOIC ACID Chemical Properties,Usage,Production
Uses
GPR81, also known as hydroxycarboxylic acid receptor 1 (HCAR1), is a recently de-orphanized receptor that is activated by lactic acid (EC50 ~ 1.5 mM) but not by other hydroxycarboxylic acids. 3-chloro-5-hydroxy Benzoic Acid (3-chloro-5-hydroxy BA) is an agonist of GPR81 (EC50 = 16 μM) that is inactive against the related GPR109a (HCAR2) receptor. It is similarly effective at GPR81 receptors from a variety of mammalian species and is bioavailable, stimulating lipolysis (increased serum free fatty acids) in mice fed high fat chow for 10 weeks. 3-chloro-5-hydroxy BA, like lactate, blocks basal ghrelin secretion by primary gastric mucosal cells.[Cayman Chemical]
Uses
5-Chloro-m-salicylic Acid was studied as a potential selective lactate receptor (GPR81) agonists with antilipolytic effects.
Biological Activity
3-chloro-5-hydroxy ba is a gpr81 agonist.gpr81 (hca1) is a member of g-protein-coupled receptors (gpcrs). gpr81 is predominantly expressed on adipocytes and is activated by the endogenous ligands 2-hydroxypropanoate (lactate). stimulation of gpr81 in adipose tissue lead to a decrease in the lipolysis of triglycerides by hormone-sensitive lipase, which resulted in reduced transport of fatty acids to the liver and a decrease in hepatic triglycerides [1].
in vitro
in the hgpr81 assay, 3-chloro-5-hydroxybenzoic acid showed the potency against gpr81 with an ec50 of 16 μm. the ec50 of 3-chloro-5-hydroxybenzoic acid against monkey gpr81, dog gpr81, rat gpr81, mouse gpr81, and hamster gpr81 was 17 μm, 67 μm, 7 μm, 22 μm and 27 μm, respectively [1]. 3-chloro-5-hydroxy ba blocked basal ghrelin secretion by primary gastric mucosal cells [2].
in vivo
in mice, oral administration of 3-chloro-5-hydroxybenzoic acid at 30 mg/kg provided a cmax of 67 μm at approximately 3-fold over the in vitro ec50 with an aucinf of 54 h μm and a short t1/2 of 1.5 h, and the 100 mg/kg p.o dose attained a cmax of 342 μm at greater than 15-fold over the observed in vitro ec50 [1].
References
[1]. dvorak c a, liu c, shelton j, et al. identification of hydroxybenzoic acids as selective lactate receptor (gpr81) agonists with antilipolytic effects[j]. acs medicinal chemistry letters, 2012, 3(8): 637-639.
[2]. engelstoft m s, park w, sakata i, et al. seven transmembrane g protein-coupled receptor repertoire of gastric ghrelin cells[j]. molecular metabolism, 2013, 2(4): 376-392.
3-CHLORO-5-HYDROXY-BENZOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
3-CHLORO-5-HYDROXY-BENZOIC ACID Suppliers
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- Country
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View Lastest Price from 3-CHLORO-5-HYDROXY-BENZOIC ACID manufacturers
- Product
- 3-CHLORO-5-HYDROXY-BENZOIC ACID 53984-36-4
- Price
- US $3.00-0.20/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-03-26
- Product
- 3-CHLORO-5-HYDROXY-BENZOIC ACID 53984-36-4
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-09-22
- Product
- 3-CHLORO-5-HYDROXY-BENZOIC ACID 53984-36-4
- Price
- US $100.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 200kg
- Release date
- 2018-08-15