ChemicalBook > CAS DataBase List > modipafant
modipafant
- Product Name
- modipafant
- CAS No.
- 122956-68-7
- Chemical Name
- modipafant
- Synonyms
- UK-74505;Modipefant;rac-Modipafant;Modipafant racemate;(Rac) Modipafant,(Rac)Modipafant;ethyl 4-(2-chlorophenyl)-6-methyl-2-(4-{2-methylimidazo[4,5-c]pyridin-1-yl}phenyl)-5-[(pyridin-2-yl)carbamoyl]-1,4-dihydropyridine-3-carboxylate - [AC77674];ethyl 4-(2-chlorophenyl)-6-methyl-2-(4-(2-methyl-1H-imidazo[4,5-c]pyridin-1-yl)phenyl)-5-(pyridin-2-ylcarbamoyl)-1,4-dihydropyridine-3-carboxylate(WXG02205);4-(2-Chlorophenyl)-1,4-dihydro-6-Methyl-2-[4-(2-Methyl-1H-iMidazo[4,5-c]pyridin-1-yl)phenyl]-5-[(2-pyridinylaMino)carbonyl]-3-pyridinecarboxylic Acid Ethyl Ester;2-[4-(2-Methyl-1H-imidazo[4,5-c]pyridin-1-yl)phenyl]-4-(2-chlorophenyl)-5-[(2-pyridinylamino)carbonyl]-6-methyl-1,4-dihydropyridine-3-carboxylic acid ethyl ester;3-Pyridinecarboxylic acid, 4-(2-chlorophenyl)-1,4-dihydro-6-methyl-2-[4-(2-methyl-1H-imidazo[4,5-c]pyridin-1-yl)phenyl]-5-[(2-pyridinylamino)carbonyl]-, ethyl ester
- CBNumber
- CB01310883
- Molecular Formula
- C34H29ClN6O3
- Formula Weight
- 605.09
- MOL File
- 122956-68-7.mol
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modipafant Property
- Density
- 1.34±0.1 g/cm3 (20 ºC 760 Torr)
- storage temp.
- Store at -20°C
- pka
- 12.14±0.70(Predicted)
- form
- Solid
- color
- Light yellow to yellow
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N-Bromosuccinimide Price
TRC
- Product number
- M482800
- Product name
- rac-Modipafant
- Packaging
- 100mg
- Price
- $9625
- Updated
- 2021/12/16
Medical Isotopes, Inc.
- Product number
- 47767
- Product name
- rac-Modipafant
- Packaging
- 25mg
- Price
- $6250
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- API0013646
- Product name
- RAC-MODIPAFANT
- Purity
- 95.00%
- Packaging
- 10MG
- Price
- $6479.55
- Updated
- 2021/12/16
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modipafant Chemical Properties,Usage,Production
Uses
Modipafant is a novel and selective PAF antagonist with potent and prolonged oral activity.
in vivo
(Rac)-Modipafant (UK-74505) (10 mg/kg; p.o.; twice a day until day 10) prevents Severe Dengue Infection[3].
(Rac)-Modipafant exhibits highly selective, time-dependent inhibition of PAF-induced aggregation of rabbit washed platelets (IC50=26.3 and 1.12 nM after 0.25 and 60 min preincubation, respectively)[4].
(Rac)-Modipafant (5-20 mg/kg; p.o.) dose-dependently inhibits the Zymosan -induced articular hyperalgesia[5].
| Animal Model: | 8- to 10-week-old BALB/c mice (DEN-2 strain infected)[3] |
| Dosage: | 10 mg/kg |
| Administration: | P.o.; twice a day (started on days 0, 3, 5, or 7) until day 10 |
| Result: | Decreased by approximately 50% the lethality associated with DEN-2 infection. |
| Animal Model: | Male BALB/C (8- to 10- week-old) wild-type mice[5] |
| Dosage: | 5, 10 and 20 mg/kg |
| Administration: | P.o. |
| Result: | Dose-dependently inhibited the Zymosan -induced articular hyperalgesia. |
modipafant Preparation Products And Raw materials
Raw materials
Preparation Products
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modipafant Suppliers
- Tel
- --
- Fax
- --
- info@trc-canada.com
- Country
- Canada
- ProdList
- 6038
- Advantage
- 71
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View Lastest Price from modipafant manufacturers
Career Henan Chemical Co
- Product
- modipafant 122956-68-7
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2018-08-20