ChemicalBook > CAS DataBase List > 2'-cyano-2'-deoxyarabinofuranosylcytosine

2'-cyano-2'-deoxyarabinofuranosylcytosine

Product Name: 2'-cyano-2'-deoxyarabinofuranosylcytosine
CAS No.: 134665-72-8
Chemical Name: 2'-cyano-2'-deoxyarabinofuranosylcytosine
Synonyms: TAS109;TAS 109;CNDAC HCl;CNDAC HCl salt;CNDAC hydrochloride;TAS-109 Hydrochloride;DFP-10917 Hydrochloride;CNDAC hydrochloride, 10 mM in DMSO;2'-cyano-2'-deoxyarabinofuranosylcytosine;2'-Cyano-2'-deoxyarabinofuranosylcytosine hydrochloride
CBNumber: CB01322158
Molecular Formula: C10H13ClN4O4
Formula Weight: 288.69
MOL File: 134665-72-8.mol

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2'-cyano-2'-deoxyarabinofuranosylcytosine Property

storage temp.: Store at -20°C
solubility: DMSO: 125 mg/mL (432.99 mM)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0022139
Product name: CNDAChydrochloride
Purity: 99.53%
Packaging: 5mg
Price: $350
Updated: 2021/12/16

ChemScene

Product number: CS-0022139
Product name: CNDAChydrochloride
Purity: 99.53%
Packaging: 50mg
Price: $1650
Updated: 2021/12/16

ChemScene

Product number: CS-0022139
Product name: CNDAChydrochloride
Purity: 99.53%
Packaging: 100mg
Price: $2250
Updated: 2021/12/16

DC Chemicals

Product number: DC10752
Product name: CNDACHCl
Purity: >98%
Packaging: 1g
Price: $2100
Updated: 2021/12/16

DC Chemicals

Product number: DC10752
Product name: CNDACHCl
Purity: >98%
Packaging: 100mg
Price: $600
Updated: 2021/12/16

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2'-cyano-2'-deoxyarabinofuranosylcytosine Chemical Properties,Usage,Production

Uses

CNDAC hydrochloride is a metabolite of the orally active agent Sapacitabine.html" class="link-product" target="_blank">Sapacitabine (HY-16445), and a nucleoside analog. CNDAC hydrochloride induces DNA damage and apoptosis[1][2].

in vivo

CNDAC (20mg/kg; i.p.; daily for 10 days) shows antitumor activity in mice^[4].

Animal Model:	CDF1 mice, P388 tumor model^[4]
Dosage:	20 mg/kg
Administration:	Intraperitoneal injection, daily for 10 days
Result:	Greatly increased the survival time and survival rate.

References

[1] Liu XJ, et al. Sapacitabine, the prodrug of CNDAC, is a nucleoside analog with a unique action mechanism of inducing DNA strand breaks. Chin J Cancer. 2012 Aug;31(8):373-80. DOI:10.5732/cjc.012.10077
[2] Jagan S, et al. Bone Marrow and Peripheral Blood AML Cells Are Highly Sensitive to CNDAC, the Active Form of Sapacitabine. Adv Hematol. 2012;2012:727683. DOI:10.1155/2012/727683
[3] Serova M, et al. Antiproliferative effects of sapacitabine (CYC682), a novel 2'-deoxycytidine-derivative, in human cancer cells. Br J Cancer. 2007 Sep 3;97(5):628-36. DOI:10.1038/sj.bjc.6603896
[4] Azuma A, et al. Nucleosides and nucleotides. 122. 2'-C-cyano-2'-deoxy-1-beta-D-arabinofuranosylcytosine and its derivatives. A new class of nucleoside with a broad antitumor spectrum. J Med Chem. 1993 Dec 24;36(26):4183-9. DOI:10.1021/jm00078a006

2'-cyano-2'-deoxyarabinofuranosylcytosine Preparation Products And Raw materials

Raw materials

Preparation Products

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134665-72-8, 2'-cyano-2'-deoxyarabinofuranosylcytosineRelated Search:

PTH-EPSILON-PHENYLTHIOCARBAMYL-DL-LYSINE

2'-cyano-2'-deoxyarabinofuranosylcytosine

CNDAC HCl salt

2'-Cyano-2'-deoxyarabinofuranosylcytosine hydrochloride

CNDAC hydrochloride

(2R,3S,4S,5R)-2-(4-amino-2-oxopyrimidin-1(2H)-yl)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-3-carbonitrile hydrochloride

CNDAC HCl

DFP-10917 Hydrochloride

DFP-10917 HYDROCHLORIDE; TAS-109 HYDROCHLORIDE;CNDAC;TAS109;TAS 109

TAS 109

TAS109

TAS-109 Hydrochloride

1-(2-C-cyano-2-deoxy-β-D-arabinofuranosyl)cytosine hydrochloride

inhibit,Drug Metabolite,CNDAC hydrochloride,Inhibitor,CNDAC,Nucleoside Antimetabolite/Analog

CNDAC hydrochloride, 10 mM in DMSO

134665-72-8