ChemicalBook > CAS DataBase List > ARV-766

ARV-766

Product Name: ARV-766
CAS No.: 2750830-09-0
Chemical Name: ARV-766
Synonyms: ARV776;Luxdegalutamide;Luxdegalutamide ARV-766;4-[4-[[1-[4-[[[trans-3-(4-Cyano-3-methoxyphenoxy)-2,2,4,4-tetramethylcyclobutyl]amino]carbonyl]phenyl]-4-piperidinyl]methyl]-1-piperazinyl]-N-[(3S)-2,6-dioxo-3-piperidinyl]-2-fluorobenzamide
CBNumber: CB013336286
Molecular Formula: C45H54FN7O6
Formula Weight: 807.95
MOL File: 2750830-09-0.mol

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ARV-766 Property

Boiling point:: 993.4±65.0 °C(Predicted)
Density: 1.32±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)
solubility: DMSO: Soluble: =10 mg/ml
form: Solid
pka: 10.58±0.40(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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ARV-766 Chemical Properties,Usage,Production

Uses

Luxdegalutamide (ARV-766) is an orally active protein hydrolysis targeted chimeric (PROTAC) targeting androgen receptor (AR), which can degrade AR resistance related mutants, including T878/H875/L702 mutants. Luxdegalutamide has anti-tumor activity and can be used in the study of castration resistant prostate cancer[1][2].

in vivo

Luxdegalutamide exhibits anti-tumor activity in mouse LNCaP and VCaP xenograft models^[2].

References

[1] Snyder L, et al. In vitro evaluation of PROTAC? degrader ARV-766 for cytochrome P450-and transporter-mediated drug-drug interaction[J]. Drug Metabolism and Pharmacokinetics, 2024, 55: 100881.
[2] Snyder L, et al. Abstract ND03: Discovery of ARV-766, an androgen receptor degrading PROTAC? for the treatment of men with metastatic castration resistant prostate cancer[J]. Cancer Research, 2023, 83(7_Supplement): ND03-ND03.

ARV-766 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from ARV-766 manufacturers

Hubei Chuchang Biotech Co., Ltd.

Product: Luxdegalutamide (ARV-766) 2750830-09-0
Price: US $0.00-0.00/mg
Min. Order: 5mg
Purity: 98%+ HPLC HNMR
Supply Ability: 20g
Release date: 2024-03-29

2750830-09-0, ARV-766Related Search:

4-[4-[[1-[4-[[[trans-3-(4-Cyano-3-methoxyphenoxy)-2,2,4,4-tetramethylcyclobutyl]amino]carbonyl]phenyl]-4-piperidinyl]methyl]-1-piperazinyl]-N-[(3S)-2,6-dioxo-3-piperidinyl]-2-fluorobenzamide

ARV776

Luxdegalutamide ARV-766

Luxdegalutamide

2750830-09-0