BMY 7378
- Product Name
- BMY 7378
- CAS No.
- 21102-94-3
- Chemical Name
- BMY 7378
- Synonyms
- BMY 7378;8-[2-[4-(2-Methoxyphenyl)piperazin-1-yl]ethyl]-8-azaspiro[4.5]decane-7,9-dione;8-Azaspiro[4.5]decane-7,9-dione, 8-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-
- CBNumber
- CB01338289
- Molecular Formula
- C22H31N3O3
- Formula Weight
- 385.5
- MOL File
- 21102-94-3.mol
BMY 7378 Property
- Boiling point:
- 585.6±50.0 °C(Predicted)
- Density
- 1.22±0.1 g/cm3(Predicted)
- pka
- 7.15±0.10(Predicted)
- InChI
- InChI=1S/C22H31N3O3/c1-28-19-7-3-2-6-18(19)24-13-10-23(11-14-24)12-15-25-20(26)16-22(17-21(25)27)8-4-5-9-22/h2-3,6-7H,4-5,8-17H2,1H3
- InChIKey
- AYYCFGDXLUPJAQ-UHFFFAOYSA-N
- SMILES
- C1C2(CC(=O)N(CCN3CCN(C4=CC=CC=C4OC)CC3)C(=O)C2)CCC1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- orb181214
- Product name
- BMY 7378
- Purity
- >98%
- Packaging
- 100mg
- Price
- $690.2
- Updated
- 2021/12/16
- Product number
- orb181214
- Product name
- BMY 7378
- Purity
- >98%
- Packaging
- 250mg
- Price
- $1356.6
- Updated
- 2021/12/16
- Product number
- orb181214
- Product name
- BMY 7378
- Purity
- >98%
- Packaging
- 1000mg
- Price
- $2691.1
- Updated
- 2021/12/16
BMY 7378 Chemical Properties,Usage,Production
Uses
BMY 7378 (free base) is a selective antagonist of α1D-adrenoceptor (α1D-AR). BMY 7378 (free base) binds to membranes expressing the cloned rat α1D-AR with a >100-fold higher affinity (Ki=2 nM) than binding to either the cloned rat α1A-AR (Ki=800 nM) or the hamster α1B-AR (Ki=600 nM). BMY 7378 (free base) is a 5-HT1A receptor partial agonist[1][2].
Definition
ChEBI: 8-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-8-azaspiro[4.5]decane-7,9-dione is a member of piperazines.
References
[1] Piascik MT, et al. The specific contribution of the novel alpha-1D adrenoceptor to the contraction of vascular smooth muscle. J Pharmacol Exp Ther. 1995;275(3):1583-1589. PMID:8531132
[2] Goetz AS, et al. BMY 7378 is a selective antagonist of the D subtype of alpha 1-adrenoceptors. Eur J Pharmacol. 1995;272(2-3):R5-R6. DOI:10.1016/0014-2999(94)00751-r
BMY 7378 Preparation Products And Raw materials
Raw materials
Preparation Products
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