BMY 7378

Product Name: BMY 7378
CAS No.: 21102-94-3
Chemical Name: BMY 7378
Synonyms: BMY 7378;8-[2-[4-(2-Methoxyphenyl)piperazin-1-yl]ethyl]-8-azaspiro[4.5]decane-7,9-dione;8-Azaspiro[4.5]decane-7,9-dione, 8-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-
CBNumber: CB01338289
Molecular Formula: C22H31N3O3
Formula Weight: 385.5
MOL File: 21102-94-3.mol

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BMY 7378 Property

Boiling point:: 585.6±50.0 °C(Predicted)
Density: 1.22±0.1 g/cm3(Predicted)
pka: 7.15±0.10(Predicted)
InChI: InChI=1S/C22H31N3O3/c1-28-19-7-3-2-6-18(19)24-13-10-23(11-14-24)12-15-25-20(26)16-22(17-21(25)27)8-4-5-9-22/h2-3,6-7H,4-5,8-17H2,1H3
InChIKey: AYYCFGDXLUPJAQ-UHFFFAOYSA-N
SMILES: C1C2(CC(=O)N(CCN3CCN(C4=CC=CC=C4OC)CC3)C(=O)C2)CCC1

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Biorbyt Ltd

Product number: orb181214
Product name: BMY 7378
Purity: >98%
Packaging: 100mg
Price: $690.2
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb181214
Product name: BMY 7378
Purity: >98%
Packaging: 250mg
Price: $1356.6
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb181214
Product name: BMY 7378
Purity: >98%
Packaging: 1000mg
Price: $2691.1
Updated: 2021/12/16

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BMY 7378 Chemical Properties,Usage,Production

Uses

BMY 7378 (free base) is a selective antagonist of α1D-adrenoceptor (α1D-AR). BMY 7378 (free base) binds to membranes expressing the cloned rat α1D-AR with a >100-fold higher affinity (Ki=2 nM) than binding to either the cloned rat α1A-AR (Ki=800 nM) or the hamster α1B-AR (Ki=600 nM). BMY 7378 (free base) is a 5-HT1A receptor partial agonist[1][2].

Definition

ChEBI: 8-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-8-azaspiro[4.5]decane-7,9-dione is a member of piperazines.

References

[1] Piascik MT, et al. The specific contribution of the novel alpha-1D adrenoceptor to the contraction of vascular smooth muscle. J Pharmacol Exp Ther. 1995;275(3):1583-1589. PMID:8531132
[2] Goetz AS, et al. BMY 7378 is a selective antagonist of the D subtype of alpha 1-adrenoceptors. Eur J Pharmacol. 1995;272(2-3):R5-R6. DOI:10.1016/0014-2999(94)00751-r

BMY 7378 Preparation Products And Raw materials

Raw materials

Preparation Products

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BMY 7378 Suppliers

China 39 Global 39

Shanghai Haozhixiang Biotechnology Co., Ltd

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21102-94-3, BMY 7378Related Search:

BMY 7378

8-[2-[4-(2-Methoxyphenyl)piperazin-1-yl]ethyl]-8-azaspiro[4.5]decane-7,9-dione

8-Azaspiro[4.5]decane-7,9-dione, 8-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-

21102-94-3