AGN 194310
- Product Name
- AGN 194310
- CAS No.
- 229961-45-9
- Chemical Name
- AGN 194310
- Synonyms
- AGN;CS-1211;VTP194310;VTP-194310;AGN 194310;VTP 194310;AGN-194310, 194310;AGN194310; AGN-194310; VTP194310; VTP 194310; VTP-194310;Benzoic acid, 4-[2-[4-(4-ethylphenyl)-2,2-dimethyl-2H-1-benzothiopyran-6-yl]ethynyl]-
- CBNumber
- CB01346990
- Molecular Formula
- C28H24O2S
- Formula Weight
- 424.55
- MOL File
- 229961-45-9.mol
AGN 194310 Property
- Boiling point:
- 598.1±50.0 °C(Predicted)
- Density
- 1.26±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- >16.8mg/mL in DMSO
- form
- Powder
- pka
- 4.02±0.10(Predicted)
- color
- White to off-white
- InChI
- 1S/C28H24O2S/c1-4-19-7-12-22(13-8-19)25-18-28(2,3)31-26-16-11-21(17-24(25)26)6-5-20-9-14-23(15-10-20)27(29)30/h7-18H,4H2,1-3H3,(H,29,30)
- InChIKey
- LHUPKWKWYWOMSK-UHFFFAOYSA-N
- SMILES
- O=C(O)C1=CC=C(C#CC2=CC3=C(SC(C)(C=C3C4=CC=C(CC)C=C4)C)C=C2)C=C1
Safety
- WGK Germany
- WGK 3
- Storage Class
- 11 - Combustible Solids
N-Bromosuccinimide Price
- Product number
- SML2665
- Product name
- AGN194310
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $142
- Updated
- 2026/03/19
- Product number
- SML2665
- Product name
- AGN194310
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $545
- Updated
- 2026/03/19
- Product number
- B4702
- Product name
- AGN194310
- Packaging
- 5mg
- Price
- $500
- Updated
- 2021/12/16
- Product number
- B4702
- Product name
- AGN194310
- Packaging
- 10mM(in 1mL DMSO)
- Price
- $514
- Updated
- 2021/12/16
- Product number
- B4702
- Product name
- AGN194310
- Packaging
- 1mg
- Price
- $158
- Updated
- 2021/12/16
AGN 194310 Chemical Properties,Usage,Production
Uses
AGN 194310 (VTP-194310) is a high affinity, potent and selective retinioic acid receptors (RARs) pan-antagonist with Kd values of 3 nM, 2 nM, 5 nM for RARα, RARβ, RARγ, respectively[1][2]. AGN 194310 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Biological Activity
AGN 194310 (VTP-194310) is a high-affinity, potent, and selective pan-antagonist of retinoic acid receptors (RARs) with Kd values of 3 nM and 2 nM for RARα, RARβ, and RARγ, respectively , 5 nM.
in vivo
AGN 194310 (0.5 mg/kg/day; oral gavage; every day; for 10 days; female C57Bl/6J mice) treatment increases the number of granulocytes across haemopoietic compartments. A significant increase in the frequency of granulocyte -progenitor cells are observed in the bone marrow of mice after treatment with AGN194310.
| Animal Model: | Female C57Bl/6J mice (Five -week-old (34-37 days)) |
| Dosage: | 0.5 mg/kg/ day |
| Administration: | Oral gavage; every day; for 10 days |
| Result: | The number of granulocytes was significantly increased across haemopoietic compartments. Progenitor cells containing granulocytes also increased significantly. |
target
| RARα 3 nM (Kd) | RARβ 2 nM (Kd) | RARγ 5 nM (Kd) | < /table>