2-naphthoylethyltrimethylammonium

Product Name: 2-naphthoylethyltrimethylammonium
CAS No.: 31059-54-8
Chemical Name: 2-naphthoylethyltrimethylammonium
Synonyms: α-NETA;β-NETA;β-NETA, 10 mM in DMSO;2-naphthoylethyltrimethylammonium;alpha-NETA, Fluorescent ChAT inhibitor;2-(beta-Naphthoyl)ethyltrimethylammonium iodide;2-Dimethylaminoethyl 2-naphthyl ketone methiodide;trimethyl-(3-naphthalen-2-yl-3-oxopropyl)azanium:iodide;histamine,Cholinesterase (ChE),Apoptosis,ChE,β-NETA,KCl,β NETA,ChA,choline acetyltransferase,βNETA,Inhibitor,cholinesterase,inhibit
CBNumber: CB01368697
Molecular Formula: C16H20NO.I
Formula Weight: 0
MOL File: 31059-54-8.mol

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2-naphthoylethyltrimethylammonium Property

storage temp.: Store at -20°C, protect from light, stored under nitrogen
solubility: DMSO: 3mg/ml; Methanol: Soluble
form: A solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 15125
Product name: α-NETA
Purity: ≥97%
Packaging: 5mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 15125
Product name: α-NETA
Purity: ≥97%
Packaging: 25mg
Price: $161
Updated: 2024/03/01

TRC

Product number: N385705
Product name: α-NETA
Packaging: 100mg
Price: $525
Updated: 2021/12/16

ChemScene

Product number: CS-0089727
Product name: β-NETA
Purity: ≥98.0%
Packaging: 10mg
Price: $80
Updated: 2021/12/16

ChemScene

Product number: CS-0089727
Product name: β-NETA
Purity: ≥98.0%
Packaging: 50mg
Price: $240
Updated: 2021/12/16

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2-naphthoylethyltrimethylammonium Chemical Properties,Usage,Production

Description

Choline acetyltransferase (ChAT) mediates the synthesis of the neurotransmitter acetylcholine from acetyl-CoA and choline. In addition to its critical role in neurosignaling, deficiencies in ChAT are linked to congenital myasthenic syndromes, Alzheimer’s disease, and multiple sclerosis. α-NETA is a stable, non-competitive, and slowly reversible inhibitor of ChAT (IC₅₀ = 9 μM). This naturally fluorescent compound is a poor inhibitor of cholinesterases and carnitine acetyltransferase. α-NETA is commonly used in cells in culture.

Uses

Choline acetyltransferase (ChAT) mediates the synthesis of the neurotransmitter acetylcholine from acetyl-CoA and choline. In addition to its critical role in neurosignaling, deficiencies in ChAT are linked to congenital myasthenic syndromes, Alzheimer’s disease, and multiple sclerosis. α-NETA is a stable, non-competitive, and slowly reversible inhibitor of ChAT (IC50 = 9 μM). This naturally fluorescent compound is a poor inhibitor of cholinesterases and carnitine acetyltransferase. α-NETA is commonly used in cells in culture.[Cayman Chemical]

Uses

alpha-NETA is a fluorescent choactase inhibitor.

IC 50

AChE

References

[1] B V SASTRY. 2-(alpha-Naphthoyl)ethyltrimethylammonium iodide and its beta-isomer: new selective, stable and fluorescent inhibitors of choline acetyltransferase.[J]. Journal of Pharmacology and Experimental Therapeutics, 1988, 245 1: 72-80.
[2] B.V. RAMA SASTRY. Relationships between chemical structure and inhibition of choline acetyltransferase by 2-(α-naphthoyl)ethyltrimethylammonium and related compounds[J]. Pharmacological research communications, 1988, 20 9: Pages 751-771. DOI: 10.1016/s0031-6989(88)80715-x
[3] B.M. EATON S. R S. Regulation of the choline transport system in superfused microcarrier cultures of BeWo cells[J]. Placenta, 1998, 19 8: Pages 663-669. DOI: 10.1016/s0143-4004(98)90028-5
[4] DEBORAH A SAWATZKY. Eosinophil-induced release of acetylcholine from differentiated cholinergic nerve cells.[J]. American journal of physiology. Lung cellular and molecular physiology, 2003, 285 6: L1296-304. DOI: 10.1152/ajplung.00107.2003

2-naphthoylethyltrimethylammonium Preparation Products And Raw materials

Raw materials

Preparation Products

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2-naphthoylethyltrimethylammonium Suppliers

China 25 United Kingdom 1 United States 9 Global 35

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31059-54-8, 2-naphthoylethyltrimethylammoniumRelated Search:

2-naphthoylethyltrimethylammonium

2-(beta-Naphthoyl)ethyltrimethylammonium iodide

2-Dimethylaminoethyl 2-naphthyl ketone methiodide

trimethyl-(3-naphthalen-2-yl-3-oxopropyl)azanium:iodide

β-NETA

α-NETA

histamine,Cholinesterase (ChE),Apoptosis,ChE,β-NETA,KCl,β NETA,ChA,choline acetyltransferase,βNETA,Inhibitor,cholinesterase,inhibit

alpha-NETA, Fluorescent ChAT inhibitor

β-NETA, 10 mM in DMSO

31059-54-8