MK 436
- Product Name
- MK 436
- CAS No.
- 33450-08-7
- Chemical Name
- MK 436
- Synonyms
- MK 436;1,2-Benzisoxazole, 3a,4,5,6,7,7a-hexahydro-3-(1-methyl-5-nitro-1H-imidazol-2-yl)-
- CBNumber
- CB01370391
- Molecular Formula
- C11H14N4O3
- Formula Weight
- 250.25
- MOL File
- 33450-08-7.mol
MK 436 Property
- Boiling point:
- 434.4±37.0 °C(Predicted)
- Density
- 1.61±0.1 g/cm3(Predicted)
- pka
- -0.55±0.25(Predicted)
MK 436 Chemical Properties,Usage,Production
Uses
MK 436 (MK-0436) is a metabolite with anti-trypanosomal activity that can be isolated from dog urine, particularly effective against Trypanosoma cruzi, the pathogen responsible for Chagas disease in South America[1][2].
References
[1] VandenHeuvel, et al. Identification of canine urinary metabolites of the antiprotozoal agent 3a, 4, 5, 6, 7, 7a-hexahydro-3-(1-methyl-5-nitro-1H-imidazol-2-yl)-1, 2-benzisoxazole. Journal of pharmaceutical sciences 69.11 (1980): 1288-1292. DOI:10.1002/jps.2600691115
[2] Jennings, et al. Treatment with suramin and 2-substituted 5-nitroimidazoles of chronic murine Trypanosoma brucei infections with central nervous system involvement. Transactions of the Royal Society of Tropical Medicine and Hygiene 77.5 (1983): 693-698. DOI:10.1016/0035-9203(83)90207-9
MK 436 Preparation Products And Raw materials
Raw materials
Preparation Products
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