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xanthoangelol

Product Name: xanthoangelol
CAS No.: 62949-76-2
Chemical Name: xanthoangelol
Synonyms: xanthoangelol;Xanthoangelol, 10 mM in DMSO;(E)-1-[3-[(E)-3,7-Dimethyl-2,6-octadienyl]-2,4-dihydroxyphenyl]-3-(4-hydroxyphenyl)-2-propen-1-one;(E)-1-(3-((E)-3,7-Dimethylocta-2,6-dien-1-yl)-2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one;2-Propen-1-one, 1-[3-[(2E)-3,7-dimethyl-2,6-octadien-1-yl]-2,4-dihydroxyphenyl]-3-(4-hydroxyphenyl)-, (2E)-
CBNumber: CB01383931
Molecular Formula: C25H28O4
Formula Weight: 392.49
MOL File: 62949-76-2.mol

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xanthoangelol Property

Melting point:: 141-143 °C
Boiling point:: 605.8±55.0 °C(Predicted)
Density: 1.165±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
form: Solid
pka: 7.57±0.50(Predicted)
color: Light yellow to yellow
InChI: InChI=1S/C25H28O4/c1-17(2)5-4-6-18(3)7-13-21-24(28)16-14-22(25(21)29)23(27)15-10-19-8-11-20(26)12-9-19/h5,7-12,14-16,26,28-29H,4,6,13H2,1-3H3/b15-10+,18-7+
InChIKey: LRSMBOSQWGHYCW-MDGZPELGSA-N
SMILES: C(C1=CC=C(O)C(C/C=C(\C)/CC/C=C(/C)\C)=C1O)(=O)/C=C/C1=CC=C(O)C=C1
LogP: 7.240 (est)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0087769
Product name: Xanthoangelol
Purity: 98.36%
Packaging: 1mg
Price: $600
Updated: 2021/12/16

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xanthoangelol Chemical Properties,Usage,Production

Uses

Xanthoangelol, extracted from Angelica keiskei, suppresses obesity-induced inflammatory responses. Xanthoangelol possesses antibacterial activity. Xanthoangelol inhibits monoamine oxidases. Xanthoangelol induces apoptosis in neuroblastoma and leukemia cells[1][2][3][4].

in vivo

Xanthoangelol (0.1% or 0.15% w/w, mixed in a high-fat diet, daily for 14 weeks) suppresses inflammatory mediators in WAT of diet-induced obese mice^[1].

Animal Model:	High-fat diet-induced obese (DIO) mice^[1]
Dosage:	0.1% or 0.15% w/w
Administration:	mixed in a high-fat diet, daily for 14 weeks
Result:	Showed fewer positively stained macrophages, suppressed the gene expression of inflammatory marker MCP-1 and TNF-a, increased oxygen consumption in DIO mice.

References

[1] Li Y, et al. Xanthoangelol and 4-hydroxyderrcin suppress obesity-induced inflammatory responses. Obesity (Silver Spring). 2016 Nov;24(11):2351-2360. DOI:10.1002/oby.21611
[2] Inamori Y, et al. Antibacterial activity of two chalcones, xanthoangelol and 4-hydroxyderricin, isolated from the root of Angelica keiskei KOIDZUMI. Chem Pharm Bull (Tokyo). 1991 Jun;39(6):1604-5. DOI:10.1248/cpb.39.1604
[3] Kim JH, et al. Xanthoangelol and 4-Hydroxyderricin Are the Major Active Principles of the Inhibitory Activities against Monoamine Oxidases on Angelica keiskei K. Biomol Ther (Seoul). 2013 May 30;21(3):234-40. DOI:10.4062/biomolther.2012.100
[4] Keiichi TABATA, et al. Xanthoangelol, a Major Chalcone Constituent of Angelica keiskei, Induces Apoptosis in Neuroblastoma and Leukemia Cells. Biol. Pharm. Bull. 28(8) 1404-1407 (2005).

xanthoangelol Preparation Products And Raw materials

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(E)-1-[3-[(E)-3,7-Dimethyl-2,6-octadienyl]-2,4-dihydroxyphenyl]-3-(4-hydroxyphenyl)-2-propen-1-one

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62949-76-2