E 2078

Product Name: E 2078
CAS No.: 103613-84-9
Chemical Name: E 2078
Synonyms: 66A-078;(N-Me-Tyr1,N-Me-Arg7,D-Leu-NHEt8)-Dynorphin;Methyl-L-Tyr-Gly-Gly-L-Phe-L-Leu-L-Arg-N2-methyl-L-Arg-D-Leu-NHEt;N-Methyl-L-Tyr-Gly-Gly-L-Phe-L-Leu-L-Arg-Nα-methyl-L-Arg-D-Leu-NHEt;(N-Me-Tyr?,N-Me-Arg?,D-Leu-NHEt?)-Dynorphin A (1-8) trifluoroacetate salt;(N-Me-Tyr1,N-Me-Arg7,D-Leu-NHEt 8)-Dynorphin A (1-8) trifluoroacetate salt;1-8-Dynorphin B (swine), N-methyl-7-(N2-methyl-L-arginine)-8-(N-ethyl-D-leucinamide)-;(2R)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-3-(4-hydroxyphenyl)-2-(methylamino)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]pentanoyl]-met
CBNumber: CB01384286
Molecular Formula: C50H81N15O9
Formula Weight: 1036.27324
MOL File: 103613-84-9.mol

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E 2078 Property

Density: 1.30±0.1 g/cm3(Predicted)
pka: 9.99±0.15(Predicted)
Sequence: {Tyr(Me)}-Gly-Gly-Phe-Leu-Arg-{Arg(N-Me)}-{d-Leu}-{NHEt}

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Hazard and Precautionary Statements (GHS)

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E 2078 Chemical Properties,Usage,Production

Uses

(N-Me-Tyr1,N-Me-Arg7,D-Leu-NHEt8)-Dynorphin A (1-8) (E-2078), a stable Dynorphin A (1–8) (HY-P2159) analog, is a kappa opioid receptor (KOR) agonist[1].

IC 50

κ Opioid Receptor/KOR

References

[1] Butelman ER, et al. Effects of E-2078, a stable dynorphin A(1-8) analog, on sedation and serum prolactin levels in rhesus monkeys. Psychopharmacology (Berl). 1999 Nov;147(1):73-80. DOI:10.1007/s002130051144

E 2078 Preparation Products And Raw materials

Raw materials

Preparation Products

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E 2078 Suppliers

China 32 United States 2 Global 34

Shanghai Hanhong Scientific Co.,Ltd.

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Chemsky (shanghai) International Co.,Ltd

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Cellmano Biotech Limited

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BOC Sciences

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Alabiotech Inc.

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Nanjing Leon Biological Technology Co., Ltd.

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Nanjing Peptide Biotech Ltd.

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Alpha Biopharmaceuticals Co., Ltd

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Nextpeptide Inc

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103613-84-9, E 2078Related Search:

H-ALA-GLY-ALA-VAL-VAL-GLY-GLY-LEU-GLY-GLY-TYR-MET-LEU-GLY-SER-ALA-MET-SER-OH (Cys8·13)-Dynorphin A (1-13) amide H-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Cys-Arg-Pro-Lys-Leu-Cys-NH2 (Disulfide bond) Acetyl-delta-Endorphin (bovine, camel, mouse, ovine) (D-Ala2)-Dynorphin A (1-9) H-Tyr-D-Ala-Gly-Phe-Leu-Arg-Arg-Ile-Arg-OH DYNORPHIN A (1-10)-GLY-CHLOROMETHYLKETONE Myristoyl Tirpeptide-4 Hexapeptide 9 Aminobutyroyl pentapeptide-4 H-GLY-HIS-OH HCL Octapeptide-10

66A-078

Methyl-L-Tyr-Gly-Gly-L-Phe-L-Leu-L-Arg-N2-methyl-L-Arg-D-Leu-NHEt

N-Methyl-L-Tyr-Gly-Gly-L-Phe-L-Leu-L-Arg-Nα-methyl-L-Arg-D-Leu-NHEt

(2R)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-3-(4-hydroxyphenyl)-2-(methylamino)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]pentanoyl]-met

1-8-Dynorphin B (swine), N-methyl-7-(N2-methyl-L-arginine)-8-(N-ethyl-D-leucinamide)-

(N-Me-Tyr?,N-Me-Arg?,D-Leu-NHEt?)-Dynorphin A (1-8) trifluoroacetate salt

(N-Me-Tyr1,N-Me-Arg7,D-Leu-NHEt 8)-Dynorphin A (1-8) trifluoroacetate salt

(N-Me-Tyr1,N-Me-Arg7,D-Leu-NHEt8)-Dynorphin

103613-84-9