BMS 191095

Product Name: BMS 191095
CAS No.: 166095-21-2
Chemical Name: BMS 191095
Synonyms: BMS 191095;BMS-191095, 10 mM in DMSO;Inhibitor,BMS-191095,KcsA,BMS191095,BMS 191095,Potassium Channel,inhibit;2H-1-Benzopyran-6-carbonitrile, 4-[(4-chlorophenyl)(1H-imidazol-2-ylmethyl)amino]-3,4-dihydro-3-hydroxy-2,2-dimethyl-, (3R,4S)-
CBNumber: CB01385834
Molecular Formula: C22H21ClN4O2
Formula Weight: 408.88
MOL File: 166095-21-2.mol

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BMS 191095 Property

Boiling point:: 649.4±55.0 °C(Predicted)
Density: 1.39±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : ≥ 50 mg/mL (122.29 mM)
form: Solid
pka: 13.19±0.60(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-5470
Product name: BMS-191095
Purity: 98.06%
Packaging: 1mg
Price: $180
Updated: 2021/12/16

ChemScene

Product number: CS-5470
Product name: BMS-191095
Purity: 98.06%
Packaging: 5mg
Price: $420
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0013822
Product name: BMS-191095
Purity: 95.00%
Packaging: 5MG
Price: $495.98
Updated: 2021/12/16

ChemScene

Product number: CS-5470
Product name: BMS-191095
Purity: 98.06%
Packaging: 10mg
Price: $600
Updated: 2021/12/16

ChemScene

Product number: CS-5470
Product name: BMS-191095
Purity: 98.06%
Packaging: 25mg
Price: $1200
Updated: 2021/12/16

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BMS 191095 Chemical Properties,Usage,Production

Uses

BMS-191095 is a selective activator of mitochondrial ATP-sensitive potassium (mitoKATP) channels. BMS-191095 inhibits human platelet aggregation by opening mitochondrial K(ATP) channels[1][2][3].

in vivo

BMS-191095 (2.5 or 25 μg; intraventricular infusion, 30 min/60 min/24 hours before the induction of ischemia, once) reduces neuronal damage in rats with transient focal cerebral ischemia^[3].

Animal Model:	Male Wistar rats with the induction of ischemia induced by middle cerebral artery occlusion (MCAO)^[3]
Dosage:	2.5 or 25 μg
Administration:	Intraventricular infusion; 30 min/60 min/24 hours before the induction of ischemia, once
Result:	Reduced total infarct volume in rats with of pretreat dose of 25 mg and 24 h before MCA. Induced a rapid mitochondrial depolarization.

References

[1] Katakam PV, et al. Diversity of mitochondria-dependent dilator mechanisms in vascular smooth muscle of cerebral arteries from normal and insulin-resistant rats. Am J Physiol Heart Circ Physiol. 2014 Aug 15;307(4):H493-503. DOI:10.1152/ajpheart.00091.2014
[2] Cho MR, et al. BMS-191095, a cardioselective mitochondrial K(ATP) opener, inhibits human platelet aggregation by opening mitochondrial K(ATP) channels. Arch Pharm Res. 2005 Jan;28(1):61-7. DOI:10.1007/BF02975137
[3] Mayanagi K, et al. The mitochondrial K(ATP) channel opener BMS-191095 reduces neuronal damage after transient focal cerebral ischemia in rats. J Cereb Blood Flow Metab. 2007 Feb;27(2):348-55. DOI:10.1038/sj.jcbfm.9600345

BMS 191095 Preparation Products And Raw materials

Raw materials

Preparation Products

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BMS 191095 Suppliers

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166095-21-2, BMS 191095Related Search:

BMS 191095

2H-1-Benzopyran-6-carbonitrile, 4-[(4-chlorophenyl)(1H-imidazol-2-ylmethyl)amino]-3,4-dihydro-3-hydroxy-2,2-dimethyl-, (3R,4S)-

Inhibitor,BMS-191095,KcsA,BMS191095,BMS 191095,Potassium Channel,inhibit

BMS-191095, 10 mM in DMSO

166095-21-2