3-aminophenoxazone

Product Name: 3-aminophenoxazone
CAS No.: 1916-59-2
Chemical Name: 3-aminophenoxazone
Synonyms: Phx-3;Questiomycin A;2-Aminophenoxazon;3-aminophenoxazone;2-AMino-3-phenoxazone;2-amino-1H-phenoxazin-3-one;2-Amino-3-oxo-3H-phenoxazine;3H-Phenoxazin-3-one, 2-aMino-;2-AMino-3H-phenoxazin-3-one, 2-AMinophenoxazone, AV Toxin C, NSC 94945
CBNumber: CB01387919
Molecular Formula: C12H8N2O2
Formula Weight: 212.2
MOL File: 1916-59-2.mol

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3-aminophenoxazone Property

Melting point:: 249-250 °C
Boiling point:: 352.04°C (rough estimate)
Density: 1.2399 (rough estimate)
refractive index: 1.6000 (estimate)
storage temp.: Store at -20°C
solubility: DMF: 2mg/mL; DMSO: 3mg/mL; DMSO:PBS (pH 7.2) (1:20): 0.04mg/mL
form: A solid
pka: 2.73±0.20(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 27623
Product name: Questiomycin A
Packaging: 1mg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 27623
Product name: Questiomycin A
Packaging: 10mg
Price: $570
Updated: 2024/03/01

Cayman Chemical

Product number: 27623
Product name: Questiomycin A
Packaging: 5mg
Price: $319
Updated: 2024/03/01

TRC

Product number: Q509800
Product name: QuestiomycinA
Packaging: 10mg
Price: $500
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611991
Product name: Questiomycin A
Purity: >98%
Packaging: 1g
Price: $4766.8
Updated: 2021/12/16

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3-aminophenoxazone Chemical Properties,Usage,Production

Description

Questiomycin A is a phenoxazine and a chromophore that has been found in Streptomyces and has antibacterial and anticancer activities. It is active against M. scrofulaceum, M. marinum, and M. intracellulare (MICs = 2.8, 11.3, and 5.6 μg/ml, respectively) but not M. tuberculosis, M. smegmatis, M. kansasii, or M. fortuitum (MICs = >45 μg/ml). It is also inactive against E. coli, P. aeruginosa, S. tymphimurium, S. aureus, or L. monocytogenes. It is cytotoxic to a variety of cancer cells, including MCF-7, A549, MIA PaCa-2, and LoVo-1 cells (IC₅₀s = 1.67, 5.48, 7.16, and 20.03 μM, respectively) as well as human umbilical vein endothelial cells (HUVECs) but not human embryonic lung fibroblast cells (HELs; IC₅₀s = 16.06 and >50 μM, respectively). Questiomycin A reduces the increased intracellular pH in a variety of cancer cell lines, as well as in HUVECs and HELs. It prevents lung metastasis in a B16 mouse melanoma model of metastasis when administered at a dose of 0.5 mg/kg simultaneously with B16 cells or every three days. It is also a chromophore product of the reducing agent 2-aminophenol oxidation (as 2-amino-phenoxazine-3-one) and has been used as a readout in the study of catalytic oxidation of 2-aminophenol by various metal-containing complexes. It has an absorbance of 435 nm in methanol.

Uses

Questiomycin A is a phenoxazine produced by several Streptomyces species and some fungi and bacteria. Questiomycin A is weakly active against bacteria, fungi, plants and tumour cell lines, and inhibits aromatase and sulfatases. Questiomycin, like other phenoxazines, stimulates cell growth and turnover in vitro, an activity possibly related to their ability to form stable free radicals. More recently, questiomycin A has been shown to inhibit pulmonary metastasis caused by mouse melanoma cells. Questiomycin A and related phenoxazines are important dereplication standards in discovery research to eliminate leads due to high amounts of weakly potent actives.

Uses

Questiomycin A is a natural antimicrobial agent produced by agriculturally important species such as maize, rye, and wheat.

Definition

ChEBI: 2-aminophenoxazin-3-one is a phenoxazine.

3-aminophenoxazone Preparation Products And Raw materials

Raw materials

Preparation Products

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3-aminophenoxazone Suppliers

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1916-59-2, 3-aminophenoxazoneRelated Search:

3-aminophenoxazone

2-Amino-3-oxo-3H-phenoxazine

2-Aminophenoxazon

Phx-3

Questiomycin A

2-AMino-3-phenoxazone

3H-Phenoxazin-3-one, 2-aMino-

2-AMino-3H-phenoxazin-3-one, 2-AMinophenoxazone, AV Toxin C, NSC 94945

2-amino-1H-phenoxazin-3-one

1916-59-2