SR 33805

Product Name: SR 33805
CAS No.: 121345-64-0
Chemical Name: SR 33805
Synonyms: SR 33805;SR33805, 10 mM in DMSO;2-(3,4-dimethoxyphenyl)ethyl](methyl)[3-(4-{[1-methyl-2-(propan-2-yl)-1H-indol-3-yl]sulfonyl}phenoxy)propyl]amine;Ca channels,channel,failing,Ca2+ channels,Ca2+,SR 33805,Calcium Channel,acute,L-type,SR-33805,Inhibitor,inhibit,depolarized,polarized,hearts,chronic,SR33805
CBNumber: CB01400869
Molecular Formula: C32H40N2O5S
Formula Weight: 564.7354
MOL File: 121345-64-0.mol

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SR 33805 Property

storage temp.: Store at -20°C
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0134392
Product name: SR33805
Purity: 99.04%
Packaging: 5mg
Price: $180
Updated: 2021/12/16

ChemScene

Product number: CS-0134392
Product name: SR33805
Purity: 99.04%
Packaging: 10mg
Price: $300
Updated: 2021/12/16

ChemScene

Product number: CS-0134392
Product name: SR33805
Purity: 99.04%
Packaging: 50mg
Price: $850
Updated: 2021/12/16

ChemScene

Product number: CS-0134392
Product name: SR33805
Purity: 99.04%
Packaging: 100mg
Price: $1300
Updated: 2021/12/16

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SR 33805 Chemical Properties,Usage,Production

Uses

SR33805 is a potent Ca2+ channel antagonist, with EC50s of 4.1 nM and 33 nM in depolarized and polarized conditions, respectively. SR33805 blocks L-type but not T-type Ca2+ channels. SR33805 can be used for the research of acute or chronic failing hearts[1][2].

in vivo

SR33805 (20 mg/kg; a single i.p.) improves end-systolic strain and fractional shortening of MI hearts in rats^[2].
SR33805 (5 mg/kg/day; p.o. for 38 d) significantly reduces intimal hyperplasia in pigs^[3].

Animal Model:	Male Wistar rats (5 weeks) are subjected to coronary artery ligature^[2]
Dosage:	0.2, 2, 20 mg/kg
Administration:	A single i.p. injection
Result:	Increased significantly both end-systolic strain (ESS) and fractional shortening (FS) by about +38 and +26%, respectively at the dose of 20 mg/kg. Did not affect other contractile parameters.

IC 50

L-type calcium channel: 4.1 nM (EC₅₀, in depolarized conditions); L-type calcium channel: 33 nM (EC₅₀, in polarized conditions)

References

[1] Romey G, et, al. Effects of two chemically related new Ca2+ channel antagonists, SR33557 (fantofarone) and SR33805, on the L-type cardiac channel. Eur J Pharmacol. 1994 Sep 22; 263(1-2): 101-5. DOI:10.1016/0014-2999(94)90529-0
[2] Mou YA, et, al. Beneficial effects of SR33805 in failing myocardium. Cardiovasc Res. 2011 Aug 1; 91(3): 412-9. DOI:10.1093/cvr/cvr096
[3] Hainaud P, et, al. The calcium inhibitor SR33805 reduces intimal formation following injury of the porcine carotid artery. Atherosclerosis. 2001 Feb 1; 154(2): 301-8. DOI:10.1016/s0021-9150(00)00487-1

SR 33805 Preparation Products And Raw materials

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Preparation Products

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SR 33805 Suppliers

China 24 United States 4 Global 28

Shanghai Lollane Biological Technology Co.,Ltd.

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121345-64-0, SR 33805Related Search:

SR 33805

Ca channels,channel,failing,Ca2+ channels,Ca2+,SR 33805,Calcium Channel,acute,L-type,SR-33805,Inhibitor,inhibit,depolarized,polarized,hearts,chronic,SR33805

2-(3,4-dimethoxyphenyl)ethyl](methyl)[3-(4-{[1-methyl-2-(propan-2-yl)-1H-indol-3-yl]sulfonyl}phenoxy)propyl]amine

SR33805, 10 mM in DMSO

121345-64-0