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GOITRINE

Product Name
GOITRINE
CAS No.
1072-93-1
Chemical Name
GOITRINE
Synonyms
Epigoitrin;GOITRINE;R-GOITRIN;D-Goitrin;Epigotrin;BA-51-090278;R、Sepigoitrin;Goitrine Epigoitrin;Epigoitrin/(R,S)-goitrin;5-VINYL-2-THIOOXAZOLIDONE
CBNumber
CB01410433
Molecular Formula
C5H7NOS
Formula Weight
129.18
MOL File
1072-93-1.mol
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GOITRINE Property

Melting point:
47.5°C
Boiling point:
150.6±43.0 °C(Predicted)
Density 
1.170 (estimate)
refractive index 
1.5480 (estimate)
storage temp. 
Amber Vial, -20°C Freezer
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
solid
pka
13.34±0.40(Predicted)
color 
White to Off-White
InChI
InChI=1S/C5H7NOS/c1-2-4-3-6-5(8)7-4/h2,4H,1,3H2,(H,6,8)/t4-/m1/s1
InChIKey
UZQVYLOFLQICCT-SCSAIBSYSA-N
SMILES
O1[C@H](C=C)CNC1=S
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Safety

Safety Statements 
24/25
HS Code 
29349990
Toxicity
mouse,LD50,unreported,1260mg/kg (1260mg/kg),Journal of Agricultural and Food Chemistry. Vol. 17, Pg. 483, 1969.
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
G766520
Product name
Goitrine
Packaging
50mg
Price
$315
Updated
2021/12/16
Usbiological
Product number
300225
Product name
Epigoitrin
Packaging
10mg
Price
$419
Updated
2021/12/16
Biosynth Carbosynth
Product number
FE42757
Product name
Epigoitrin
Packaging
5mg
Price
$50
Updated
2021/12/16
ChemScene
Product number
CS-0008262
Product name
Epigoitrin
Purity
99.91%
Packaging
5mg
Price
$60
Updated
2021/12/16
Biosynth Carbosynth
Product number
FE42757
Product name
Epigoitrin
Packaging
10mg
Price
$90
Updated
2021/12/16
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GOITRINE Chemical Properties,Usage,Production

Chemical Properties

Derived from the root of Isatis indigotica Fort.

Uses

Goitrine is a cyclic thiocarbamate that is seen reducing production of thyroid hormones.

Definition

ChEBI: (R)-goitrin is a 5-ethenyl-1,3-oxazolidine-2-thione that has R-configuration. It is a constituent of a traditional Chinese herbal medicine, Radix isatidis. It has a role as an antiviral agent and a plant metabolite. It is an enantiomer of a (S)-goitrin.

Biological Activity

Epigoitrin is a sulfur containing alkaloid isolated from Isatis indigotica (Ban Lan Gen) th at exhibits antiviral, anticancer, and antithyroid activities. Epigoitrin significantly decreases the susceptibility of restraint mice to H1N1 influenza virus. Epigoitrin and goitrin appear to show virucidal effect on influenza virus A (H1N1) in vitro and in ovo.

in vivo

Epigoitrin (88-176 mg/kg/d; oral administration; once daily; for 7 consecutive days) reduces the susceptibility of mice to influenza virus in a restraint - stress - induced H1N1 virus - infected mouse model, manifested as reduced mortality, attenuated inflammation, and decreased viral replication in the lungs[1].
Epigoitrin (50-100 mg/kg; added to the feed; for 12 weeks) reduces fat deposition, improves glucose tolerance and insulin sensitivity, and increases energy expenditure in a high-fat diet-induced obese mouse model[3].

Animal Model:Five-week-old male C57BL/6J mice were fed a high-fat diet to establish an obesity model[3].
Dosage:50 mg/kg, 100 mg/kg
Administration:Added to the feed, continuously administered for 12 weeks
Result:Reduced fat deposition in HFD mice.
Reduced adipocyte hypertrophy.
Alleviated hepatic steatosis, as shown by reduced liver lipid droplets and lower liver and serum TG and TC levels.
Had no effect on food intake.
Animal Model:Specific-pathogen-free male Kunming mice (4 weeks of age; 12-15 g) loaded with restraint stress[1]
Dosage:88 mg/kg, 176 mg/kg
Administration:Oral administration, once daily, for 7 days
Result:Increased the survival rate, prolonged the mean day to death, and reduced the morbidity sign.
Significantly decreased the virus titer in the lungs, reduced the infiltration of inflammatory cells in the lungs, and lowered the levels of TNF-α and IL-1β in bronchoalveolar lavage fluid.
Increased the protein expressions of MAVS, IFN-β, and IFITM3 in the lung tissue, and decreased the protein level of MFN2 and virus nucleoprotein (NP) in stressed mice.

target

Influenza virus

GOITRINE Preparation Products And Raw materials

Raw materials

Preparation Products

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GOITRINE Suppliers

China 225 Germany 1 Switzerland 1 United Kingdom 1 United States 13 Global 241
Sichuan Hongen Plant Technology Co., Ltd.
Tel
+86-17340288373
Fax
86-838-2803556
Email
2370026295@qq.com
Country
China
ProdList
37
Advantage
58
Chengdu Biopurify Phytochemicals Ltd.
Tel
+86-028-82633397 18982077548
Fax
+86-28-82633165
Email
cwb1@biopurify.cn
Country
China
ProdList
2376
Advantage
60
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6003
Advantage
61
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11705
Advantage
57
China Langchem Inc.
Tel
0086-21-58956006
Fax
0086-21-58956100
Country
China
ProdList
7811
Advantage
57
Shenzhen Sungening Bio-Tech Co., Ltd
Tel
+86-0755-89668383
Fax
+86-0755-89594066/4038
Email
sales@sungening.com
Country
China
ProdList
1319
Advantage
65
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4747
Advantage
58
BioBioPha Co., Ltd.
Tel
0871-65217109 13211707573;
Fax
0871-65215563
Email
y.liu@mail.biobiopha.com
Country
China
ProdList
5645
Advantage
65
Chengdu Ai Keda Chemical Technology Co., Ltd.
Tel
4008-755-333 18080918076
Fax
028-86757656
Email
800078821@qq.com
Country
China
ProdList
9718
Advantage
55
Chengdu Climax Biotech Co., Ltd.
Tel
028-83311324 1278112614
Fax
028-83311324
Email
climaxbiotech@gmail.com
Country
China
ProdList
925
Advantage
58
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View Lastest Price from GOITRINE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
GOITRINE 1072-93-1
Price
US $0.10/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10
Release date
2024-07-07
Shanghai Standard Technology Co., Ltd.
Product
Epigoitrin 1072-93-1
Price
US $0.00/mg
Min. Order
5mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2019-09-29
Shanghai Standard Technology Co., Ltd.
Product
Epigoitrin 1072-93-1
Price
US $0.00/mg
Min. Order
5mg
Purity
Analytical Standard
Supply Ability
10 g
Release date
2019-09-29

1072-93-1, GOITRINERelated Search:

Sulfaquinoxaline Lincomycin GLUCOTROPAEOLIN 4-Methoxybenzoic acid 2-(4-hydroxyphenyl)ethyl ester Hydroxycitric acid Xanthiside Z-LIGUSTILIDE Camphene menisdaurin ALPHA-CARYOPHYLLENE Muscone Xanthiazone DL-GOITRIN 2-THIOXOTETRAHYDRO-1,3-OXAZOLE GOITRINE

  • GOITRINE
  • R-GOITRIN
  • 5-VINYL-2-THIOOXAZOLIDONE
  • (-)5-VINYL-2-OXAZOLIDINETHIONE
  • (5R)-5-Vinyloxazolidine-2-thione
  • (5R)-5β-Vinyloxazolidine-2-thione
  • (R)-5-Vinyl-2-oxazolidinethione
  • BA-51-090278
  • D-Goitrin
  • (R)-5-Ethenyl-2-oxazolidinethione
  • Epigoitrin
  • Epigoitrin/(R,S)-goitrin
  • Goitrine Epigoitrin
  • Epigotrin
  • Goitrine, 98%, from Isatis indigotica Fortune
  • R、Sepigoitrin
  • 2-Oxazolidinethione, 5-ethenyl-, (5R)-
  • (R)-5-Vinyloxazolidine-2-thione
  • Oxazolidinethione Impurity 2
  • Epigoitrin, 10 mM in DMSO
  • 1072-93-1
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract