20-DEOXYINGENOL

Product Name: 20-DEOXYINGENOL
CAS No.: 54706-99-9
Chemical Name: 20-DEOXYINGENOL
Synonyms: 20-DEOXYINGENOL;20-Deoxyingenol, >98%;20-deoxyingenol 54706-99-9;20-DEOXYINGENOL, 10 mM in DMSO;(1aR,10aα)-1a,2,5,5a,6,9,10,10a-Octahydro-5β,5aβ,6β-trihydroxy-1,1,4,7,9α-pentamethyl-1H-2α,8aα-methanocyclopenta[a]cyclopropa[e]cyclodecen-11-one;(1aR,2S,5R,5aS,6S,8aS,9R,10aR)-5,5a,6-Trihydroxy-1,1,4,7,9-pentamethyl-1a,2,5,5a,6,9,10,10a-octahydro-1H-2,8a-methanocyclopenta[a]cyclopropa[e][10]annulen-11-one;1H-2,8a-Methanocyclopenta[a]cyclopropa[e]cyclodecen-11-one, 1a,2,5,5a,6,9,10,10a-octahydro-5,5a,6-trihydroxy-1,1,4,7,9-pentamethyl-, (1aR,2S,5R,5aS,6S,8aS,9R,10aR)-
CBNumber: CB01430727
Molecular Formula: C20H28O4
Formula Weight: 332.43
MOL File: 54706-99-9.mol

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20-DEOXYINGENOL Property

Melting point:: 208-209℃(Decomposition)
Boiling point:: 470.5±45.0 °C(Predicted)
Density: 1.26±0.1 g/cm3 (20 ºC 760 Torr)
storage temp.: Store at -20°C
solubility: DMSO : 50 mg/mL (150.41 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
form: Powder
pka: 12.21±0.70(Predicted)
color: White to off-white
InChIKey: FOSYZKSOJUQLTD-NHPMXQBPSA-N
SMILES: [C@@]12(O)[C@@H](O)C(C)=C[C@@]31C(=O)[C@@]([H])(C=C(C)[C@H]2O)[C@]1([H])C(C)(C)[C@]1([H])C[C@H]3C

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Usbiological

Product number: 361732
Product name: 20-deoxyingenol
Packaging: 20mg
Price: $849
Updated: 2021/12/16

TRC

Product number: D239770
Product name: 20-Deoxyingenol
Packaging: 10mg
Price: $1320
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb593695
Product name: 20-deoxyingenol
Packaging: 10mg
Price: $513.4
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 69159
Product name: 20-Deoxyingenol
Packaging: 1mg
Price: $650
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb593695
Product name: 20-deoxyingenol
Packaging: 20mg
Price: $654.5
Updated: 2021/12/16

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20-DEOXYINGENOL Chemical Properties,Usage,Production

Uses

20-Deoxyingenol is a diterpene derivative of Ingenol (I655795), the analogue of Ingenol 3-Angelate (I655800), which has anti-tumor activity when used topically for the treatment of actinic keratosis.

in vivo

20-Deoxyingenol (20 mg/kg/d; i.p. for 8 weeks) alleviates the progression of OA in the DMM model in mice^[2].

Animal Model:	10-week-old C57BL/6 male wild-type (WT) mice with destabilization of the medial meniscus (DMM)^[2]
Dosage:	20 mg/kg
Administration:	I.p. one time per day, for eight consecutive weeks
Result:	Had a slightly wider joint space and reduced bone density and calcification compared with the DMM group. Inhibited the decrease in the thickness of hyaline cartilage (HC), and alleviated the disorder and hypertrophy of chondrocytes in the joint tissues of mice after DMM surgery. Had less erosion on the surface of the articular cartilage and more proteoglycan content. Had more positive staining points of LAMP1 and LC3 II, and less cleaved-caspase3 and P16INK4a. Increased the nuclear level of TFEB.

20-DEOXYINGENOL Preparation Products And Raw materials

Raw materials

Preparation Products

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20-DEOXYINGENOL Suppliers

China 105 India 1 United States 12 Global 118

Nanjing Spring & Autumn Biological Engineering Co., Ltd.

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Chembest Research Laboratories Limited

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BOC Sciences

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Dalian Meilun Biotech Co., Ltd.

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Chengdu Biopurify Phytochemicals Ltd.

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Shanghai T&W Pharmaceutical Co., Ltd.

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Haoyuan Chemexpress Co., Ltd.

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Shanghai Tauto Biotech Co., Ltd.

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Shanghai BeiZhuo Biotech Co., Ltd.

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Shanghai Yongye Biotechnology Co., Ltd.

Tel: 86-021-61559134 15921386130
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View Lastest Price from 20-DEOXYINGENOL manufacturers

NanJing Spring & Autumn Biological Engineering CO., LTD.

Product: 20-deoxyingenol 54706-99-9 54706-99-9
Price: US $42.00/g
Min. Order: 10mg
Purity: 98.00% HPLC
Supply Ability: 1000.00 kgs
Release date: 2019-06-27

Career Henan Chemical Co

Product: 20-DEOXYINGENOL 54706-99-9
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-23

54706-99-9, 20-DEOXYINGENOLRelated Search:

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20-DEOXYINGENOL

(1aR,10aα)-1a,2,5,5a,6,9,10,10a-Octahydro-5β,5aβ,6β-trihydroxy-1,1,4,7,9α-pentamethyl-1H-2α,8aα-methanocyclopenta[a]cyclopropa[e]cyclodecen-11-one

20-deoxyingenol 54706-99-9

20-Deoxyingenol, >98%

1H-2,8a-Methanocyclopenta[a]cyclopropa[e]cyclodecen-11-one, 1a,2,5,5a,6,9,10,10a-octahydro-5,5a,6-trihydroxy-1,1,4,7,9-pentamethyl-, (1aR,2S,5R,5aS,6S,8aS,9R,10aR)-

20-DEOXYINGENOL, 10 mM in DMSO

(1aR,2S,5R,5aS,6S,8aS,9R,10aR)-5,5a,6-Trihydroxy-1,1,4,7,9-pentamethyl-1a,2,5,5a,6,9,10,10a-octahydro-1H-2,8a-methanocyclopenta[a]cyclopropa[e][10]annulen-11-one

54706-99-9