ChemicalBook > CAS DataBase List > 4-CHLORO-2-METHYLPHENYLBORONIC ACID

4-CHLORO-2-METHYLPHENYLBORONIC ACID

Product Name: 4-CHLORO-2-METHYLPHENYLBORONIC ACID
CAS No.: 209919-30-2
Chemical Name: 4-CHLORO-2-METHYLPHENYLBORONIC ACID
Synonyms: AKOS BRN-0229;4-CHLORO-2-METHYLPHENYL;2-Borono-5-chlorotoluene;4-chloro-o-tolylboronic acid;4-CHLORO-O-TOLUENEBORONIC ACID;4-Chloro-2-Methylphenylboronic;4-CHLORO-2-METHYLPHENYLBORONIC ACID;(4-chloro-2-methylphenyl)boronicaci;4-CHLORO-2-METHYLBENZENEBORONIC ACID;(2-Methyl-4-chlorophenyl)boronic acid
CBNumber: CB0146513
Molecular Formula: C7H8BClO2
Formula Weight: 170.4
MOL File: 209919-30-2.mol

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4-CHLORO-2-METHYLPHENYLBORONIC ACID Property

Melting point:: 193-195°C
Boiling point:: 314.9±52.0 °C(Predicted)
Density: 1.26±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: soluble in Methanol
form: powder to crystal
pka: 8.47±0.58(Predicted)
color: White to Almost white
InChIKey: SRXXSLUUAWHGBZ-UHFFFAOYSA-N
CAS DataBase Reference: 209919-30-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-20/21/22
Safety Statements: 26-36/37/39-36
HazardClass: IRRITANT
HS Code: 29319090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: C2577
Product name: 4-Chloro-2-methylphenylboronic Acid (contains varying amounts of Anhydride)
Packaging: 1g
Price: $34
Updated: 2025/07/31

TCI Chemical

Product number: C2577
Product name: 4-Chloro-2-methylphenylboronic Acid (contains varying amounts of Anhydride)
Packaging: 5g
Price: $99
Updated: 2025/07/31

TRC

Product number: C587458
Product name: 4-Chloro-2-methylphenylboronicacid
Packaging: 250mg
Price: $55
Updated: 2021/12/16

Usbiological

Product number: 270306
Product name: 4-Chloro-2-methylphenylboronic acid
Packaging: 10g
Price: $355
Updated: 2021/12/16

Chem-Impex

Product number: 28643
Product name: 4-Chloro-2-methylphenylboronicacid,98%
Purity: 98%
Packaging: 1G
Price: $11.2
Updated: 2021/12/16

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4-CHLORO-2-METHYLPHENYLBORONIC ACID Chemical Properties,Usage,Production

Chemical Properties

White solid

Uses

suzuki reaction

Synthesis

14495-51-3

209919-30-2

The general procedure for the synthesis of 2-methyl-4-chlorophenylboronic acid from 2-bromo-5-chlorotoluene was as follows: first, 13.3 mL (0.1 mol) of 2-bromo-5-chlorotoluene was dissolved in 200 mL of anhydrous tetrahydrofuran (THF), followed by the addition of 27.7 mL (0.12 mol) of triisopropyl borate. After cooling the reaction mixture to -78°C in a dry ice-acetone bath, 48 mL (0.12 mol) of 2.5 M n-butyllithium (n-BuLi, dissolved in hexane) was added slowly dropwise over a period of 1 hour. After completion of the dropwise addition, the dry ice-acetone bath was removed. 150 mL of 3N hydrochloric acid (HCl) was added to the reaction mixture and the resulting mixture was stirred for 1 hour. Subsequently, the separated aqueous layer was extracted twice with 100 mL of ethyl acetate. The organic layers were combined, washed with saturated brine solution and dried with anhydrous magnesium sulfate (MgSO?). After removal of the solvent by filtration under reduced pressure, the residue was recrystallized by 10% ethyl acetate/hexane solvent mixture to give 13.8 g (81% yield) of 2-methyl-4-chlorophenylboronic acid as a white solid. The product was characterized by 1H NMR (300 MHz, CDCl?) with chemical shifts of δ 8.07 (dd, 1H, J = 5.7 Hz, 2.8 Hz), 7.28-7.26 (m, 2H), 2.76 (s, 3H).

References

[1] Patent: WO2005/123054, 2005, A1. Location in patent: Page/Page column 23

4-CHLORO-2-METHYLPHENYLBORONIC ACID Preparation Products And Raw materials

Raw materials

Tetrahydrofuran Triisopropyl borate 1-Bromo-4-chloro-2-methylbenzene n-Butyllithium

Preparation Products

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4-CHLORO-2-METHYLPHENYLBORONIC ACID Suppliers

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View Lastest Price from 4-CHLORO-2-METHYLPHENYLBORONIC ACID manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 4-CHLORO-2-METHYLPHENYLBORONIC ACID 209919-30-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-14

LY Global chemicals co.,ltd .

Product: 4-CHLORO-2-METHYLPHENYLBORONIC ACID 209919-30-2
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98.0%min
Supply Ability: 100kg
Release date: 2023-03-19

Zhuozhou Wenxi import and Export Co., Ltd

Product: 4-CHLORO-2-METHYLPHENYLBORONIC ACID 209919-30-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

209919-30-2, 4-CHLORO-2-METHYLPHENYLBORONIC ACIDRelated Search:

AKOS BRN-0229

4-CHLORO-O-TOLUENEBORONIC ACID

4-CHLORO-2-METHYLBENZENEBORONIC ACID

4-CHLORO-2-METHYLPHENYLBORONIC ACID

4-Chloro-2-Methylphenylboronic

4-chloro-o-tolylboronic acid

4-Chloro-2-methylphenylboronic acid ,98%

4-Chloro-2-Methylphenylboronic Acid (contains varying aMounts of Anhydride)

4-Chloro-2-methylbenzeneboronic Acid 4-Chloro-o-tolylboronic Acid

2-Borono-5-chlorotoluene

(2-Methyl-4-chlorophenyl)boronic acid

4-CHLORO-2-METHYLPHENYL

Boronic acid, B-(4-chloro-2-methylphenyl)-

(4-chloro-2-methylphenyl)boronicaci

4-Chloro-2-methylphenylboronic acid - [C2228]

209919-30-2

C7H8ClBO2

Aryl

Boronic acid

Organoborons

blocks

BoronicAcids