ChemicalBook > CAS DataBase List > 5-METHYL-1,3-THIAZOLE-4-CARBOXYLIC ACID

5-METHYL-1,3-THIAZOLE-4-CARBOXYLIC ACID

Product Name
5-METHYL-1,3-THIAZOLE-4-CARBOXYLIC ACID
CAS No.
120237-76-5
Chemical Name
5-METHYL-1,3-THIAZOLE-4-CARBOXYLIC ACID
Synonyms
4-Carboxy-5-methyl-1,3-thiazole;5-Methylthiazol-4-carboxylic acid;5-methyl-4-thiazolecarboxylic acid;4-Thiazolecarboxylicacid, 5-Methyl-;5-METHYL-1,3-THIAZOLE-4-CARBOXYLIC ACID
CBNumber
CB01466490
Molecular Formula
C5H5NO2S
Formula Weight
143.16
MOL File
120237-76-5.mol
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5-METHYL-1,3-THIAZOLE-4-CARBOXYLIC ACID Property

Boiling point:
303.6±22.0 °C(Predicted)
Density 
1.418±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
form 
Solid
pka
4.05±0.10(Predicted)
Appearance
Off-white to yellow Solid
InChI
InChI=1S/C5H5NO2S/c1-3-4(5(7)8)6-2-9-3/h2H,1H3,(H,7,8)
InChIKey
OIWNDJQQIMISPC-UHFFFAOYSA-N
SMILES
S1C(C)=C(C(O)=O)N=C1
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Safety

HS Code 
2934100090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
M331463
Product name
5-Methylthiazole-4-carboxylicAcid
Packaging
10mg
Price
$45
Updated
2021/12/16
Apolloscientific
Product number
OR40207
Product name
5-Methyl-1,3-thiazole-4-carboxylicacid
Purity
98%
Packaging
250mg
Price
$24
Updated
2021/12/16
SynQuest Laboratories
Product number
8H21-1-Y4
Product name
5-Methyl-1,3-thiazole-4-carboxylic acid
Purity
98%
Packaging
250mg
Price
$28
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
M13353
Product name
5-Methylthiazole-4-carboxylicacid
Packaging
1g
Price
$40
Updated
2021/12/16
Apolloscientific
Product number
OR40207
Product name
5-Methyl-1,3-thiazole-4-carboxylicacid
Purity
98%
Packaging
1g
Price
$44
Updated
2021/12/16
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5-METHYL-1,3-THIAZOLE-4-CARBOXYLIC ACID Chemical Properties,Usage,Production

Synthesis

68751-05-3

120237-76-5

The general procedure for the synthesis of 5-methylthiazole-4-carboxylic acid from methyl 5-methylthiazole-4-carboxylate was as follows: with reference to Example 56, to a solution of methyl 5-methyl-1,3-thiazole-4-carboxylate (1.17 g, 7.4 mmol) in methanol (15 mL) was added an aqueous solution of 8N sodium hydroxide (2.00 mL), and the reaction mixture was stirred for 18 hours at room temperature. Upon completion of the reaction, 6N hydrochloric acid (2.67 mL) was slowly added to the mixture for neutralization, followed by concentration of the mixture under reduced pressure. An appropriate amount of water was added to the concentrated residue and the precipitate precipitated was collected by filtration and washed with cold water. The resulting precipitate was suspended in a solvent mixture of ethyl acetate (9 mL) and ethanol (1 mL) and stirred at 80 °C for 3 minutes. After the mixture was cooled to room temperature, the precipitate was collected by filtration, washed with ethyl acetate and finally dried under reduced pressure to afford the target product 5-methylthiazole-4-carboxylic acid (531 mg, 50% yield) as a light yellow solid. The product was characterized by 1H-NMR (DMSO-d6, 300 MHz): δ 2.71 (3H, s), 8.87 (1H, s), 12.88 (1H, br s).

References

[1] Patent: US2009/137595, 2009, A1
[2] Bioorganic and Medicinal Chemistry Letters, 2005, vol. 15, # 16, p. 3732 - 3736

5-METHYL-1,3-THIAZOLE-4-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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5-METHYL-1,3-THIAZOLE-4-CARBOXYLIC ACID Suppliers

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120237-76-5, 5-METHYL-1,3-THIAZOLE-4-CARBOXYLIC ACIDRelated Search:

2-METHYLTHIAZOLE-4,5-DICARBOXYLIC ACID DIETHYL ESTER 4-Thiazolecarboxylicacid,2,5-dimethyl-,ethylester(9CI) ETHYL 5-ACETYL-2-PHENYLTHIAZOLE-4-CARBOXYLATE 2-PHENYL-1,3-THIAZOLE-4,5-DICARBOXYLIC ACID METHYL 2-AMINO-5-PHENYL-1,3-THIAZOLE-4-CARBOXYLATE METHYL 2-AMINO-5-ISOPROPYL-1,3-THIAZOLE-4-CARBOXYLATE 2-CHLORO-5-ISOPROPYL-1,3-THIAZOLE-4-CARBOXYLIC ACID 2-PHENYL-1,3-THIAZOLE-4,5-DICARBOXYLIC ACID DIETHYL ESTER METHYL 2-AMINO-5-ETHYL-1,3-THIAZOLE-4-CARBOXYLATE BUTTPARK 153\57-34 CBI-BB ZERO/008505 METHYL 2-({[(4-CHLOROBENZOYL)AMINO]CARBONOTHIOYL}AMINO)-5-METHYL-1,3-THIAZOLE-4-CARBOXYLATE DIETHYL 2-AMINOTHIAZOLE-4,5-DICARBOXYLATE HYDROBROMIDE SALOR-INT L254266-1EA 2-AMINO-5-METHYL-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER DIETHYL 2-AMINO-1,3-THIAZOLE-4,5-DICARBOXYLATE AURORA KA-736 SALOR-INT L174092-1EA

  • 5-METHYL-1,3-THIAZOLE-4-CARBOXYLIC ACID
  • 5-methyl-4-thiazolecarboxylic acid
  • 4-Carboxy-5-methyl-1,3-thiazole
  • 5-Methylthiazol-4-carboxylic acid
  • 4-Thiazolecarboxylicacid, 5-Methyl-
  • 120237-76-5
  • Thiazole series
  • Carboxylic Acids
  • Thiazoles, Isothiazoles &Benzothiazoles
  • Carboxylic Acids
  • Thiazoles, Isothiazoles & Benzothiazoles