3,6-Dichloro-4-methylpyridazine
- Product Name
- 3,6-Dichloro-4-methylpyridazine
- CAS No.
- 19064-64-3
- Chemical Name
- 3,6-Dichloro-4-methylpyridazine
- Synonyms
- SW-104;SWF-104;BUTTPARK 47\04-25;3,6-Dichloro-4-Methy;Risdiplam Impurity 11;3,6-Dichloro-4-Methyl-pyr...;3,6-Dichloro-5-methylpyridazine;4-METHYL-3,6-DICHLOROPYRIDAZINE;3,6-DICHLORO-4-METHYLPYRIDAZINE;3,4-DICHLORO-4-METHYLPYRIDAZINE
- CBNumber
- CB0148072
- Molecular Formula
- C5H4Cl2N2
- Formula Weight
- 163
- MOL File
- 19064-64-3.mol
3,6-Dichloro-4-methylpyridazine Property
- Melting point:
- 86-88 °C (lit.)
- Boiling point:
- 149-151 °C/21 mmHg (lit.)
- Density
- 1.5462 (rough estimate)
- refractive index
- 1.6300 (estimate)
- Flash point:
- 149-151°C/21mm
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- soluble in Methanol
- pka
- -0.56±0.10(Predicted)
- form
- Crystalline Powder
- color
- Brown
- BRN
- 119573
- InChI
- InChI=1S/C5H4Cl2N2/c1-3-2-4(6)8-9-5(3)7/h2H,1H3
- InChIKey
- ROYHWGZNGMXQEU-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NN=C(Cl)C=C1C
- CAS DataBase Reference
- 19064-64-3(CAS DataBase Reference)
- NIST Chemistry Reference
- Pyridazine, 3,6-dichloro-4-methyl-(19064-64-3)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-20/21/22
- Safety Statements
- 26-37/39-36/37/39-22
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29339980
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 297747
- Product name
- 3,6-Dichloro-4-methylpyridazine
- Purity
- 97%
- Packaging
- 1g
- Price
- $49.9
- Updated
- 2023/06/20
- Product number
- D4206
- Product name
- 3,6-Dichloro-4-methylpyridazine
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $37
- Updated
- 2025/07/31
- Product number
- D4206
- Product name
- 3,6-Dichloro-4-methylpyridazine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $129
- Updated
- 2025/07/31
- Product number
- D437238
- Product name
- 3,6-Dichloro-4-methylpyridazine
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- D437238
- Product name
- 3,6-Dichloro-4-methylpyridazine
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
3,6-Dichloro-4-methylpyridazine Chemical Properties,Usage,Production
Chemical Properties
Brown crystalline powder.
Uses
3,6-Dichloro-4-methylpyridazine has been used in the synthesis of 7-methyl-2-phenylimidazo[1,2-b]pyridazine-3-carboxylic acid.
Application
3,6-Dichloro-4-methylpyridazine is mainly used as an intermediate in pesticides and pharmaceuticals.
Hazard
3,6-Dichloro-4-methylpyridazine causes skin irritation and serious eye irritation, it may cause respiratory irritation.
Synthesis
5754-18-7
19064-64-3
4-Methyl-1,2-dihydropyridazine-3,6-dione (9.48 g, 75.2 mmol) was suspended in phosphoryl chloride (70 mL, 750 mmol) under nitrogen protection and stirred at room temperature. Subsequently, the reaction mixture was heated to a mild reflux condition and maintained for 4 hours until a golden yellow homogeneous solution was formed. Upon completion of the reaction, the mixture was cooled and the excess trichlorophosphorus was removed by distillation under reduced pressure (14 mbar, 50-70°C). The resulting viscous brown oil was slowly added dropwise to an ice-cooled saturated sodium bicarbonate solution (200 mL) while stirring vigorously. The pH of the mixture was adjusted to 6 by batchwise addition of solid sodium bicarbonate, followed by extraction with ethyl acetate (2 x 60 mL). The organic phases were combined, washed with saturated sodium bicarbonate solution (30 mL), dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to afford 3,6-dichloro-4-methylpyridazine (11.5 g, 70.8 mmol, 94% yield) as a yellow powder. The product was recrystallized from light petroleum ether/ether and had a melting point of 87-88°C. IR spectrum (KBr, cm^-1): 3054, 1567, 1434, 1351, 1326, 1145, 1121, 914, 720. NMR hydrogen spectrum (200 MHz, CDCl3): δ 2.42 (3H, d, J = 1.0 Hz), 7.41 ( 1H, q, J = 0.9 Hz). NMR carbon spectrum (50 MHz, CDCl3): δ 19.2 (CH3), 130.1 (CH-5), 140.7 (C-4), 155.6 (C-6), 157.3 (C-3). Low resolution mass spectrum (EI): m/z 162 ([M+]). Calculated elemental analysis (C5H4Cl2N2): C, 36.84; H, 2.47; N, 17.19. Measured values: C, 36.93; H, 2.57; N, 17.48.
References
[1] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 5, p. 1644 - 1658
[2] Journal of the American Chemical Society, 1954, vol. 76, p. 2201
[3] Pharmaceutical Bulletin, 1957, vol. 5, p. 587,588
[4] Helvetica Chimica Acta, 1954, vol. 37, p. 121,131
[5] Journal of the American Chemical Society, 1954, vol. 76, p. 4454,4457
3,6-Dichloro-4-methylpyridazine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3,6-Dichloro-4-methylpyridazine manufacturers
- Product
- 3,6-Dichloro-4-methylpyridazine 19064-64-3
- Price
- US $2.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 100000
- Release date
- 2024-08-14
- Product
- 3,6-Dichloro-4-methylpyridazine 19064-64-3
- Price
- US $19.00/ASSAYS
- Min. Order
- 100ASSAYS
- Purity
- 99%
- Supply Ability
- 100 mt
- Release date
- 2024-11-20
- Product
- 3,6-Dichloro-4-methylpyridazine 19064-64-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-09-29