ChemicalBook > CAS DataBase List > 5,6,7,8-Tetrahydro-[1,2,4]triazolo[1,5-a]pyrazine

5,6,7,8-Tetrahydro-[1,2,4]triazolo[1,5-a]pyrazine

Product Name: 5,6,7,8-Tetrahydro-[1,2,4]triazolo[1,5-a]pyrazine
CAS No.: 233278-56-3
Chemical Name: 5,6,7,8-Tetrahydro-[1,2,4]triazolo[1,5-a]pyrazine
Synonyms: 4H,5H,6H,7H-[1,2,4]triazolo[1,5-a]pyrazine;5,6,7,8-Tetrahydro-[1,2,4]triazolo[1,5-a]pyrazine;[1,2,4]Triazolo[1,5-a]pyrazine, 5,6,7,8-tetrahydro-
CBNumber: CB01481956
Molecular Formula: C5H8N4
Formula Weight: 124.14
MOL File: 233278-56-3.mol

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5,6,7,8-Tetrahydro-[1,2,4]triazolo[1,5-a]pyrazine Property

Boiling point:: 319.8±52.0 °C(Predicted)
Density: 1.53±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 6.05±0.20(Predicted)
Appearance: White to light brown Solid

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: T796278
Product name: 5,6,7,8-Tetrahydro[1,2,4]triazolo[1,5-a]pyrazine
Packaging: 50mg
Price: $45
Updated: 2021/12/16

AK Scientific

Product number: W4710
Product name: 5,6,7,8-Tetrahydro[1,2,4]triazolo[1,5-a]pyrazine
Packaging: 100mg
Price: $115
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H31-1-BE
Product name: 5H,6H,7H,8H-[1,2,4]Triazolo[1,5-a]pyrazine
Purity: 97%
Packaging: 250mg
Price: $192
Updated: 2021/12/16

Matrix Scientific

Product number: 072775
Product name: 5,6,7,8-Tetrahydro[1,2,4]triazolo[1,5-a]pyrazine
Purity: 95+%
Packaging: 500mg
Price: $200
Updated: 2021/12/16

Matrix Scientific

Product number: 072775
Product name: 5,6,7,8-Tetrahydro[1,2,4]triazolo[1,5-a]pyrazine
Purity: 95+%
Packaging: 1g
Price: $370
Updated: 2021/12/16

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5,6,7,8-Tetrahydro-[1,2,4]triazolo[1,5-a]pyrazine Chemical Properties,Usage,Production

Synthesis

399-66-6

233278-56-3

Platinum(IV) oxide (2.75 g, 12.1 mmol) was added to a suspension of 2-methoxyethanol (150 mL) containing calcium oxide (9.30 g, 166 mmol) and [1,2,4]triazolo[1,5-a]pyrazine (18.10 g, 151 mmol) under nitrogen protection. The reaction mixture was stirred under hydrogen atmosphere for 21.5 h before being filtered through diatomaceous earth and washed with a solvent mixture of dichloromethane/ethanol (9:1). The filtrate was concentrated, co-evaporated with toluene and diisopropyl ether, subsequently dissolved in ethyl acetate, filtered again through diatomaceous earth and washed with ethyl acetate, after which it was concentrated again. The resulting residue was dissolved in hot diisopropyl ether, filtered, washed with diisopropyl ether and finally concentrated under vacuum for 7 hours. The product 5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-A]pyrazine was obtained in a yield of 17.12 g (92% yield).

References

[1] Patent: US2008/153843, 2008, A1. Location in patent: Page/Page column 68
[2] Journal of Medicinal Chemistry, 2014, vol. 57, # 9, p. 3687 - 3706
[3] Patent: WO2006/9886, 2006, A1. Location in patent: Page/Page column 46
[4] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 21, p. 5934 - 5939
[5] Patent: WO2009/90055, 2009, A1. Location in patent: Page/Page column 108; 109

5,6,7,8-Tetrahydro-[1,2,4]triazolo[1,5-a]pyrazine Preparation Products And Raw materials

Raw materials

Preparation Products

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233278-56-3, 5,6,7,8-Tetrahydro-[1,2,4]triazolo[1,5-a]pyrazineRelated Search:

Meldrum's Acid Fenasi 2-METHYL-5,6,7,8-TETRAHYDRO-[1,2,4]TRIAZOLO[1,5-A]PYRAZINE 2-(TRIFLUOROMETHYL)-5,6,7,8-TETRAHYDRO[1,2,4]TRIAZOLO[1,5-A]PYRAZINE HYDROCHLORIDE 2-(trifluoromethyl)-5,6,7,8-tetrahydro-8-methyl-[1,2,4]triazolo[1,5-a]pyrazine [1,2,4]TRIAZOLO[1,5-A]PYRAZINE, 5,6,7,8-TETRAHYDRO-2-PHENYL- [1,2,4]TRIAZOLO[1,5-A]PYRAZINE-2,7(8H)-DICARBOXYLIC ACID, 5,6-DIHYDRO-, 7-(1,1-DIMETHYLETHYL) 2-ETHYL ESTER 2-CYCLOPROPYL-5,6,7,8-TETRAHYDRO-[1,2,4]TRIAZOLO[1,5-A]PYRAZINE 5,6,7,8-Tetrahydro-[1,2,4]triazolo[1,5-a]pyrazine 2-(TRIFLUOROMETHYL)-5,6,7,8-TETRAHYDRO-[1,2,4]TRIAZOLO[1,5-A]PYRAZINE

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4H,5H,6H,7H-[1,2,4]triazolo[1,5-a]pyrazine

233278-56-3