(5-CHLORO-2-IODOPHENYL) 2,6-DIFLUOROPHENYL METHANO
- Product Name
- (5-CHLORO-2-IODOPHENYL) 2,6-DIFLUOROPHENYL METHANO
- CAS No.
- 869365-97-9
- Chemical Name
- (5-CHLORO-2-IODOPHENYL) 2,6-DIFLUOROPHENYL METHANO
- Synonyms
- (5-CHLORO-2-IODOPHENYL) 2,6-DIFLUOROPHENYL METHANO;Methanone, (5-chloro-2-iodophenyl)(2,6-difluorophenyl)-
- CBNumber
- CB01482342
- Molecular Formula
- C13H6ClF2IO
- Formula Weight
- 378.54
- MOL File
- 869365-97-9.mol
(5-CHLORO-2-IODOPHENYL) 2,6-DIFLUOROPHENYL METHANO Property
- Boiling point:
- 433.5±45.0 °C(Predicted)
- Density
- 1.802±0.06 g/cm3 (20 ºC 760 Torr)
- storage temp.
- 2-8°C(protect from light)
- Appearance
- Off-white to light yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 093473
- Product name
- (5-Chloro-2-iodophenyl)-(2,6-difluorophenyl)methanone
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $288
- Updated
- 2021/12/16
- Product number
- 093473
- Product name
- (5-Chloro-2-iodophenyl)-(2,6-difluorophenyl)methanone
- Purity
- 95+%
- Packaging
- 1g
- Price
- $639
- Updated
- 2021/12/16
- Product number
- HCH0069076
- Product name
- (5-CHLORO-2-IODOPHENYL)(2,6-DIFLUOROPHENYL)METHANONE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $3349.5
- Updated
- 2021/12/16
- Product number
- A172533
- Product name
- (5-Chloro-2-iodophenyl)(2,6-difluorophenyl)methanone
- Purity
- 98%
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- A172533
- Product name
- (5-Chloro-2-iodophenyl)(2,6-difluorophenyl)methanone
- Purity
- 98%
- Packaging
- 250mg
- Price
- $120
- Updated
- 2021/12/16
(5-CHLORO-2-IODOPHENYL) 2,6-DIFLUOROPHENYL METHANO Chemical Properties,Usage,Production
Synthesis
28910-83-0
869365-97-9
2-Amino-5-chloro-2,6-difluorobenzophenone (1aa) (2.6 g, 9.7 mmol) was used as a raw material, which was dissolved in acetic acid (10 mL) and concentrated hydrochloric acid (4 mL), and the solution was cooled to 0 °C. A solution of sodium nitrite (NaNO2) (0.7 g, 10.7 mmol) in water (6 mL) was added dropwise while maintaining the temperature at 0-5 °C. After addition, the reaction mixture was stirred at 0 °C for 30 min. Subsequently, cold ethyl acetate (EtOAc) (20 mL) was added dropwise and the solution was stirred for 20 minutes. Next, a solution of iodine (I2) (1.5 g, 5.8 mmol) and potassium iodide (KI) (1.9 g, 11.6 mmol) in water (10 mL) was added drop-wise, and the mixture was slowly warmed to room temperature and stirred for 1 hour. Upon completion of the reaction, the reaction mixture was diluted with ethyl acetate (200 mL) and washed with saturated sodium thiosulfate (Na2S2O3) aqueous solution (4 x 100 mL). The combined aqueous phases were back-extracted with ethyl acetate (3 x 50 mL). All organic phases were combined and washed sequentially with saturated sodium bicarbonate (NaHCO3) aqueous solution (3×50 mL), water (2×50 mL), dried with anhydrous sodium sulfate (Na2SO4), filtered, and concentrated under reduced pressure to afford the target product (5-chloro-2-iodophenyl)(2,6-difluorophenyl)methanone (2aa) (3.3 g, 90% yield) as a light yellow solid.
References
[1] Patent: US2005/256102, 2005, A1. Location in patent: Page/Page column 141
[2] ACS Medicinal Chemistry Letters, 2015, vol. 6, # 6, p. 630 - 634
[3] Angewandte Chemie - International Edition, 2012, vol. 51, # 27, p. 6598 - 6603
[4] Patent: WO2011/103089, 2011, A1. Location in patent: Page/Page column 39-40
(5-CHLORO-2-IODOPHENYL) 2,6-DIFLUOROPHENYL METHANO Preparation Products And Raw materials
Raw materials
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