1-Methylpyrrolidine-2-carboxylic acid

Product Name: 1-Methylpyrrolidine-2-carboxylic acid
CAS No.: 68078-09-1
Chemical Name: 1-Methylpyrrolidine-2-carboxylic acid
Synonyms: proline, 1-methyl-;N-methyl DL-proline;1-Methyl-DL-proline;DL-Proline, 1-methyl-;1-methylproline(SALTDATA: HCl);1-Methylpyrrolidine-2-carboxylic acid
CBNumber: CB01483374
Molecular Formula: C6H11NO2
Formula Weight: 129.16
MOL File: 68078-09-1.mol

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1-Methylpyrrolidine-2-carboxylic acid Property

Melting point:: 116 °C
Boiling point:: 227.1±33.0 °C(Predicted)
Density: 1.153±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 2.37±0.20(Predicted)
Appearance: White to yellow Solid
InChI: InChI=1S/C6H11NO2/c1-7-4-2-3-5(7)6(8)9/h5H,2-4H2,1H3,(H,8,9)/t5-/m0/s1
InChIKey: CWLQUGTUXBXTLF-YFKPBYRVSA-N
SMILES: C(O)(=O)[C@@H]1CCCN1C

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-B1576
Product name: 1-Methyl-DL-proline
Purity: >98.0%
Packaging: 250mg
Price: $118
Updated: 2021/12/16

Apolloscientific

Product number: OR938983
Product name: 1-Methyl-DL-proline
Purity: 97%
Packaging: 250mg
Price: $195
Updated: 2021/12/16

ChemScene

Product number: CS-B1576
Product name: 1-Methyl-DL-proline
Purity: >98.0%
Packaging: 1g
Price: $295
Updated: 2021/12/16

Apolloscientific

Product number: OR938983
Product name: 1-Methyl-DL-proline
Purity: 97%
Packaging: 500mg
Price: $301
Updated: 2021/12/16

Matrix Scientific

Product number: 176839
Product name: 1-Methylproline
Packaging: 1g
Price: $432
Updated: 2021/12/16

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1-Methylpyrrolidine-2-carboxylic acid Chemical Properties,Usage,Production

Synthesis

50-00-0

147-85-3

475-11-6

GENERAL METHOD: L-proline (2.0 g, 17.4 mmol) was dissolved in methanol (20 mL), to which 40% aqueous formaldehyde (1.4 mL, 19.1 mmol) was subsequently added. Next, 10% Pd/C catalyst (500 mg) was added to the reaction mixture and the resulting slurry was stirred overnight under hydrogen atmosphere. Upon completion of the reaction, the slurry was filtered through a diatomaceous earth pad to remove the catalyst. The diatomaceous earth pad was washed with methanol and the filtrates were combined and concentrated under reduced pressure. The residue was dissolved in a solvent mixture of ethanol/benzene (1:1, 100 mL) and concentrated again under reduced pressure to give a solid product. Finally, the product was purified by recrystallization from methanol/ether mixed solvent to give N-methyl-L-proline (7a) as fine needle-like crystals (2.1 g, 92% yield); melting point 109-111 °C; 1H NMR (D2O, 300 MHz): δ= 3.95-3.90 (1H, m, CH2(CH2)2CHNCH3), 3.24-3.15 (2H , m, CH2(CH2)2CHNCH3), 2.97 (3H, s, CH2(CH2)2CHNCH3), 2.22-2.01 (4H, m, CH2(CH2)2CHNCH3); ESI-MS (m/z): 130.2 [M + H]+ (100).

References

[1] Journal of Organic Chemistry, 2003, vol. 68, # 7, p. 2652 - 2667
[2] Green Chemistry, 2016, vol. 18, # 16, p. 4374 - 4392
[3] European Journal of Organic Chemistry, 2005, # 5, p. 934 - 938
[4] Tetrahedron Letters, 2007, vol. 48, # 43, p. 7680 - 7682
[5] Medicinal Chemistry Research, 2016, vol. 25, # 6, p. 1148 - 1162

1-Methylpyrrolidine-2-carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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1-Methylpyrrolidine-2-carboxylic acid Suppliers

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68078-09-1, 1-Methylpyrrolidine-2-carboxylic acidRelated Search:

1-Methylpyrrolidine-2-carboxylic acid

1-methylproline(SALTDATA: HCl)

proline, 1-methyl-

N-methyl DL-proline

DL-Proline, 1-methyl-

1-Methyl-DL-proline

68078-09-1