3-BROMO-4-METHOXY-BENZENESULFONYL CHLORIDE

3-BROMO-4-METHOXY-BENZENESULFONYL CHLORIDE Property

Melting point:

83-88°C

Boiling point:

366.0±27.0 °C(Predicted)

Density 

1.717±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

form 

solid

Appearance

Off-white to pink Solid

Sensitive 

Moisture Sensitive

CAS DataBase Reference

23094-96-4

Safety

Hazard Codes 

C

Risk Statements 

22-34

Safety Statements 

26-36/37/39-45

RIDADR 

UN 3261 8 / PGII

WGK Germany 

3

HazardClass 

IRRITANT

HazardClass 

8

HS Code 

2930909899

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

3-BROMO-4-METHOXY-BENZENESULFONYL CHLORIDE Chemical Properties,Usage,Production

Synthesis

General procedure for the synthesis of 3-bromo-4-methoxybenzene-1-sulfonyl chloride from 2-bromoanisole: 2-bromo-1-methoxybenzene (1.87 g, 10.0 mmol) was dissolved in chloroform (5 mL), and the solution was cooled in an iced salt bath to -5 °C to 0 °C. Chlorosulfonic acid (2.0 mL, 30.0 mmol) was slowly added dropwise over 30 minutes, and after completion of the dropwise addition, the reaction mixture was gradually warmed to room temperature over 1 hour. Subsequently, the reaction mixture was poured onto crushed ice and transferred to a dispensing funnel. The aqueous layer was separated and extracted twice with chloroform. The organic layers were combined, dried and concentrated to give 3-bromo-4-methoxybenzenesulfonyl chloride (2.80 g, 98%). 3-Bromo-4-methoxybenzenesulfonyl chloride (2.80 g, 9.8 mmol) was dissolved in dichloromethane (30 mL), triethylamine (1.76 mL, 12.6 mmol) was added to the solution, followed by slow dropwise addition of tert-butylamine (1.33 mL, 12.6 mmol). The reaction mixture was allowed to stand for 2 hours and then poured into a mixture of 5% citric acid solution and dichloromethane. The organic layer was separated and the aqueous layer was extracted twice with dichloromethane. The organic layers were combined, dried and concentrated. The crude product was recrystallized by ethyl acetate/hexane mixed solvent to give 3-bromo-N-tert-butyl-4-methoxybenzenesulfonamide (2.43 g, 77%).

References

[1] Patent: WO2004/50637, 2004, A2. Location in patent: Page 68-69
[2] Patent: WO2004/62661, 2004, A1. Location in patent: Page/Page column 24-25; 37-38
[3] Patent: US2015/25068, 2015, A1. Location in patent: Paragraph 0794
[4] Journal of the Chemical Society [Section] C: Organic, 1969, p. 1341 - 1345
[5] Bioorganic and Medicinal Chemistry Letters, 1997, vol. 7, # 4, p. 485 - 488