ChemicalBook > CAS DataBase List > 3,6-DICHLORO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID

3,6-DICHLORO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID

Product Name
3,6-DICHLORO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID
CAS No.
34576-94-8
Chemical Name
3,6-DICHLORO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID
Synonyms
BT2;BT2, 10 mM in DMSO;3,6-DICHLORO-BENZO[B]THIOPHENE-2-CARBOXY;Bcl-2 Family,BT2,Inhibitor,BT-2,inhibit,BT 2;3,6-dichlorobenzothiophene-2-carboxylic acid;3,6-dichloro-2-benzothiophenecarboxylic acid;3,6-Dichloro-1-benzothiophene-2-carboxylicaci;3,6-Dichlorobenzo[β]thiophene-2-carboxylic acid;Benzo[b]thiophene-2-carboxylic acid, 3,6-dichloro-;JR-6478, 3,6-Dichlorobenzo[b]thiophene-2-carboxylic acid, 97%
CBNumber
CB01492789
Molecular Formula
C9H4Cl2O2S
Formula Weight
247.1
MOL File
34576-94-8.mol
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3,6-DICHLORO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID Property

Boiling point:
426.4±40.0 °C(Predicted)
Density 
1.653±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Soluble in DMSO (up to at least 20 mg/ml)
pka
2.09±0.30(Predicted)
form 
solid
color 
Off-white
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
22948
Product name
3,6-dichloro-benzo[b]thiophene-2-Carboxylic Acid
Purity
≥95%
Packaging
100mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
22948
Product name
3,6-dichloro-benzo[b]thiophene-2-Carboxylic Acid
Purity
≥95%
Packaging
250mg
Price
$63
Updated
2024/03/01
Cayman Chemical
Product number
22948
Product name
3,6-dichloro-benzo[b]thiophene-2-Carboxylic Acid
Purity
≥95%
Packaging
500mg
Price
$109
Updated
2024/03/01
American Custom Chemicals Corporation
Product number
COR0002384
Product name
3,6-DICHLOROBENZO[B]THIOPHENE-2-CARBOXYLIC ACID
Purity
95.00%
Packaging
1G
Price
$721.57
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD57151
Product name
3,6-Dichlorobenzo[b]thiophene-2-carboxylic acid
Packaging
2g
Price
$450
Updated
2021/12/16
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3,6-DICHLORO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID Chemical Properties,Usage,Production

Description

3,6-dichloro-benzo[b]thiophene-2-Carboxylic acid is an inhibitor of myeloid cell leukemia 1 (Mcl-1) with a Ki value of 59 μM for binding of FITC-Mcl-1-BH2 peptide binding to Mcl-1. It has been used as a building block in the synthesis of inhibitors of Mcl-1, the toll-like receptor 3/double-stranded RNA (TLR3/dsRNA) complex, and D-amino acid oxidase (DAO).

References

1) Tso et al. (2014), Benzothiophene carboxylate derivatives as novel allosteric inhibitors of branched-chain α-ketoacid dehydrogenase kinase; J. Biol. Chem., 289 20583 2) Friberg et al. (2013), Discovery of potent myeloid cell leukemia (Mcl 1) inhibitors using fragment based methods and structure based design; J. Med. Chem. 56 15

3,6-DICHLORO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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3,6-DICHLORO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID Suppliers

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View Lastest Price from 3,6-DICHLORO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID manufacturers

Career Henan Chemical Co
Product
3,6-DICHLORO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID 34576-94-8
Price
US $1.00/KG
Min. Order
1KG
Purity
96%
Supply Ability
500kg
Release date
2018-08-20

34576-94-8, 3,6-DICHLORO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACIDRelated Search:

ZM 447439 TYRPHOSTIN AG 879 2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- AAL-993 Biphenyl-4,4'-dicarboxylic acid Indole 3,4,6-TRICHLORO-1-BENZOTHIOPHENE-2-CARBOXYLIC ACID ETHYL 3,6-DICHLORO-1-BENZOTHIOPHENE-2-CARBOXYLATE 3,6-DICHLORO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID METHYL 3 6-DICHLOROBENZO(B)THIOPHENE-2-& METHYL 3,4,6-TRICHLOROBENZO[B]THIOPHENE-2-CARBOXYLATE 3,4,6-trichloro-7-fluorobenzo[b]thiophene-2-carboxylic acid

  • 3,6-dichloro-2-benzothiophenecarboxylic acid
  • 3,6-dichlorobenzothiophene-2-carboxylic acid
  • BT2
  • JR-6478, 3,6-Dichlorobenzo[b]thiophene-2-carboxylic acid, 97%
  • Benzo[b]thiophene-2-carboxylic acid, 3,6-dichloro-
  • 3,6-Dichloro-1-benzothiophene-2-carboxylicaci
  • 3,6-DICHLORO-BENZO[B]THIOPHENE-2-CARBOXY
  • Bcl-2 Family,BT2,Inhibitor,BT-2,inhibit,BT 2
  • 3,6-Dichlorobenzo[β]thiophene-2-carboxylic acid
  • BT2, 10 mM in DMSO
  • 34576-94-8