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ChemicalBook > CAS DataBase List > 4-BROMO-ISOTHIAZOLE

4-BROMO-ISOTHIAZOLE

Application
Product Name
4-BROMO-ISOTHIAZOLE
CAS No.
24340-77-0
Chemical Name
4-BROMO-ISOTHIAZOLE
Synonyms
4-BROMO-ISOTHIAZOLE;4-broMo-1,2-thiazole;ISOTHIAZOLE, 4-BROMO-;4-Bromoisothiazole USP/EP/BP;4-Bromoisothiazole≥ 95% (NMR)
CBNumber
CB0149473
Molecular Formula
C3H2BrNS
Formula Weight
164.02
MOL File
24340-77-0.mol
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4-BROMO-ISOTHIAZOLE Property

Boiling point:
83.5±23.0 °C(Predicted)
Density 
1.857±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
1.59±0.22(Predicted)
form 
solid
color 
Light Yellow
InChI
InChI=1S/C3H2BrNS/c4-3-1-5-6-2-3/h1-2H
InChIKey
XAGKUQWKQVTDSK-UHFFFAOYSA-N
SMILES
S1C=C(Br)C=N1
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Safety

HS Code 
2934100090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B685583
Product name
4-Bromoisothiazole
Packaging
50mg
Price
$45
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB50959
Product name
4-Bromoisothiazole
Packaging
50mg
Price
$50
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB50959
Product name
4-Bromoisothiazole
Packaging
100mg
Price
$80
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB50959
Product name
4-Bromoisothiazole
Packaging
250mg
Price
$125
Updated
2021/12/16
AK Scientific
Product number
W4788
Product name
4-Bromoisothiazole
Packaging
1g
Price
$158
Updated
2021/12/16
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4-BROMO-ISOTHIAZOLE Chemical Properties,Usage,Production

Application

4-Bromoisothiazol is a pharmaceutical intermediate that can be prepared by one-step bromination of isothiazole and can be used to prepare Bcr-Abl1 kinase inhibitors.

Chemical Properties

White to off-white solid

Synthesis

288-16-4

24340-77-0

General procedure for the synthesis of 4-bromoisothiazole from isothiazole: Bromine (12.5 g, 78.12 mmol) was added slowly and dropwise to a solution of isothiazole (5.0 g, 58.82 mmol) in acetic acid (37 mL) over a period of 20 min at 95 °C. The reaction mixture was stirred continuously at 95 °C for 6 h and subsequently cooled to room temperature. The cooled mixture was poured into ice water (100 mL). The resulting mixture was extracted with ether (200 mL x 2). The organic phases were combined and washed with 6N sodium hydroxide solution to pH 7-8, followed by drying with anhydrous sodium sulfate and filtration. The filtrate was concentrated under reduced pressure and the resulting residue was purified by distillation to give 4-bromoisothiazole as a white solid (1.5 g, 15% yield).

References

[1] Patent: WO2017/176961, 2017, A1. Location in patent: Paragraph 00375
[2] Journal of Medicinal Chemistry, 1968, vol. 11, # 1, p. 70 - 73

4-BROMO-ISOTHIAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-BROMO-ISOTHIAZOLE Suppliers

China 104 Europe 1 India 1 Russia 1 United Kingdom 3 United States 15 Global 125
Shanghai Carlow Chemicals Co., Ltd.
Tel
21-33526724 18930996265
Fax
+86 21 37023730
Email
info@carlowchem.com
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China
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1969
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50
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
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76
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
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China
ProdList
18207
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66
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9976
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Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9310
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66
Pure Chemistry Scientific Inc.
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001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
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sales@chemreagents.com
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United States
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10186
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Accela ChemBio Co.,Ltd.
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021-50795510 4000665055
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021-50795055
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sales@accelachem.com
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China
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Shanghai Longsheng chemical Co.,Ltd.
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021-58099652-8005 13585536065
Fax
021-58099609
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bin.wu@shlschem.com
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China
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9883
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Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
16077
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64
Beijing Eternalchem Co,. Ltd.
Tel
010-59484199 18611897322
Email
sales@eternalchem.com
Country
China
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4383
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View Lastest Price from 4-BROMO-ISOTHIAZOLE manufacturers

Nanjing jinheyou Trading Co., Ltd.
Product
24340-77-0 24340-77-0
Price
US $0.00/g
Min. Order
1g
Purity
95%min
Supply Ability
20kg/month
Release date
2019-12-25
Career Henan Chemical Co
Product
4-BROMO-ISOTHIAZOLE 24340-77-0
Price
US $1.00/KG
Min. Order
1KG
Purity
96%
Supply Ability
500kg
Release date
2018-08-20

24340-77-0, 4-BROMO-ISOTHIAZOLERelated Search:

4-Bromo-3-methyl-isothiazole 4-BROMO-ISOTHIAZOLE 4-BROMO-3-METHYL-ISOTHIAZOL-5-YLAMINE 4-Bromo-3-(3-(trifluoromethyl)phenyl)-5-isothiazolecarboxylic acid

  • ISOTHIAZOLE, 4-BROMO-
  • 4-BROMO-ISOTHIAZOLE
  • 4-broMo-1,2-thiazole
  • 4-Bromoisothiazole≥ 95% (NMR)
  • 4-Bromoisothiazole USP/EP/BP
  • 24340-77-0
  • 4340-77-0
  • Halides
  • Thiazoles, Isothiazoles &Benzothiazoles
  • Thiazoles, Isothiazoles & Benzothiazoles