(S)-1-(5-Bromopyridin-2-yl)pyrrolidin-3-ol

Product Name: (S)-1-(5-Bromopyridin-2-yl)pyrrolidin-3-ol
CAS No.: 946002-90-0
Chemical Name: (S)-1-(5-Bromopyridin-2-yl)pyrrolidin-3-ol
Synonyms: (3S)-1-(5-bromo-2-pyridyl)pyrrolidin-3-ol;(S)-1-(5-Bromopyridin-2-yl)pyrrolidin-3-ol;(3S)-1-(5-bromopyridin-2-yl)pyrrolidin-3-ol;3-Pyrrolidinol, 1-(5-bromo-2-pyridinyl)-, (3S)-
CBNumber: CB01500969
Molecular Formula: C9H11BrN2O
Formula Weight: 243.1
MOL File: 946002-90-0.mol

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(S)-1-(5-Bromopyridin-2-yl)pyrrolidin-3-ol Property

Boiling point:: 379.5±42.0 °C(Predicted)
Density: 1.616±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 14.57±0.20(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: CCH0001533
Product name: (S)-1-(5-BROMOPYRIDIN-2-YL)PYRROLIDIN-3-OL
Purity: 95.00%
Packaging: 5MG
Price: $496.91
Updated: 2021/12/16

AK Scientific

Product number: 6426DD
Product name: (S)-1-(5-Bromopyridin-2-yl)pyrrolidin-3-ol
Packaging: 100mg
Price: $321
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CCH0001533
Product name: (S)-1-(5-BROMOPYRIDIN-2-YL)PYRROLIDIN-3-OL
Purity: 95.00%
Packaging: 500MG
Price: $1126.65
Updated: 2021/12/16

Crysdot

Product number: CD11006411
Product name: (S)-1-(5-Bromopyridin-2-yl)pyrrolidin-3-ol
Purity: 95+%
Packaging: 250mg
Price: $349
Updated: 2021/12/16

Alichem

Product number: 946002900
Product name: (S)-1-(5-Bromopyridin-2-yl)pyrrolidin-3-ol
Packaging: 250mg
Price: $369.6
Updated: 2021/12/16

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(S)-1-(5-Bromopyridin-2-yl)pyrrolidin-3-ol Chemical Properties,Usage,Production

Synthesis

624-28-2

100243-39-8

946002-90-0

To a stirred solution of 2,5-dibromopyridine (1.0 g, 4.2 mmol) in tert-butanol (5 ml) was added (S)-3-hydroxypyrrolidine (0.74 g, 8.44 mmol; Aldrich) and sodium carbonate (1.34 g, 12.70 mmol). The reaction mixture was placed in a reaction flask and heated to reflux at 140 °C for 3 hours. After completion of the reaction, it was cooled to room temperature and the reaction mixture was diluted with water (20 ml) and subsequently extracted with ethyl acetate (20 ml). The aqueous phase was separated and the extraction was repeated once more with ethyl acetate (20 ml). The organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give a brown oily crude product. The crude product was purified by column chromatography (eluent: 100% dichloromethane → 90:10:1 dichloromethane:methanol:ammonia) to afford the target compound (S)-1-(5-bromopyridin-2-yl)pyrrolidin-3-ol as a white solid (1.0 g, 97% yield).1H NMR (400 MHz, CDCl3) δppm2.01-2.20 (m 3H), 3.41-3.60 (m, 4H), 4.58-4.61 (m, 1H), 6.23 (d, 1H), 7.45 (dd, 1H), 8.11 (d, 1H).LRMS m/z (APCI) 377 [MH+].

References

[1] Patent: US2008/85884, 2008, A1. Location in patent: Page/Page column 69
[2] Patent: US2009/88457, 2009, A1. Location in patent: Page/Page column 17
[3] Patent: US2009/62342, 2009, A1. Location in patent: Page/Page column 11
[4] Patent: US2009/176823, 2009, A1. Location in patent: Page/Page column 39
[5] Patent: WO2007/88514, 2007, A1. Location in patent: Page/Page column 104-105

(S)-1-(5-Bromopyridin-2-yl)pyrrolidin-3-ol Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-1-(5-Bromopyridin-2-yl)pyrrolidin-3-ol Suppliers

China 14 India 1 United States 4 Global 19

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