TERT-BUTYL 2-BROMO-6,7-DIHYDROTHIENO[3,2-C]PYRIDINE-5(4H)CARBOXYLATE

Product Name: TERT-BUTYL 2-BROMO-6,7-DIHYDROTHIENO[3,2-C]PYRIDINE-5(4H)CARBOXYLATE
CAS No.: 949922-62-7
Chemical Name: TERT-BUTYL 2-BROMO-6,7-DIHYDROTHIENO[3,2-C]PYRIDINE-5(4H)CARBOXYLATE
Synonyms: 2-c]pyridine-5(4H)-carboxylate;N-Boc-2-bromo-4,5,6,7-tetrahydrothieno[3,2-c]pyridine;2-Bromo-5-Boc-4,5,6,7-tetrahydrothieno[3,2-c]pyridine;tert-Butyl 2-bromo-6,7-dihydrothieno[3,2-c]pyridine-5(4H);tert-butyl 2-broMo-4H,5H,6H,7H-thieno[3,2-c]pyridine-5-carboxylate;TERT-BUTYL 2-BROMO-6,7-DIHYDROTHIENO[3,2-C]PYRIDINE-5(4H)CARBOXYLATE;tert-butyl 2-bromo-6,7-dihydro-4H-thieno[3,2-c]pyridine-5-carboxylate;2-Bromo-6,7-dihydro-4H-thieno[3,2-c]pyridine-5-carboxylic acid tert-butyl ester;2-bromo-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-carboxylic acid tert-butyl ester;Thieno[3,2-c]pyridine-5(4H)-carboxylic acid, 2-bromo-6,7-dihydro-, 1,1-dimethylethyl ester
CBNumber: CB01502347
Molecular Formula: C12H16BrNO2S
Formula Weight: 318.23
MOL File: 949922-62-7.mol

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TERT-BUTYL 2-BROMO-6,7-DIHYDROTHIENO[3,2-C]PYRIDINE-5(4H)CARBOXYLATE Property

Boiling point:: 382.8±42.0 °C(Predicted)
Density: 1.445±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: -1.62±0.20(Predicted)
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B695315
Product name: tert-Butyl2-Bromo-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-carboxylate
Packaging: 1g
Price: $310
Updated: 2021/12/16

Matrix Scientific

Product number: 069998
Product name: tert-Butyl 2-Bromo-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-carboxylate
Purity: >95%
Packaging: 1g
Price: $415
Updated: 2021/12/16

Matrix Scientific

Product number: 069998
Product name: tert-Butyl 2-Bromo-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-carboxylate
Purity: >95%
Packaging: 5g
Price: $1176
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0105990
Product name: TERT-BUTYL 2-BROMO-6,7-DIHYDROTHIENO(3,2-C)PYRIDINE-5(4H)-CARBOXYLATE
Purity: 95.00%
Packaging: 1G
Price: $1783.32
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0105990
Product name: TERT-BUTYL 2-BROMO-6,7-DIHYDROTHIENO(3,2-C)PYRIDINE-5(4H)-CARBOXYLATE
Purity: 95.00%
Packaging: 5G
Price: $5463.15
Updated: 2021/12/16

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TERT-BUTYL 2-BROMO-6,7-DIHYDROTHIENO[3,2-C]PYRIDINE-5(4H)CARBOXYLATE Chemical Properties,Usage,Production

Synthesis

230301-73-2

949922-62-7

Tert-butyl 6,7-dihydrothieno[3,2-c]pyridine-5(4H)-carboxylate (5.0 g, 20.89 mmol) was used as starting material and dissolved in acetonitrile (25 mL). To this solution was added N-bromosuccinimide (4.09 g, 22.98 mmol) at room temperature and the reaction mixture was stirred overnight. Upon completion of the reaction, the reaction was quenched by the addition of water (50 mL) and subsequently extracted with ethyl acetate (50 mL × 2). The organic phases were combined and washed sequentially with water (50 mL × 2) and saturated brine (40 mL), then dried over anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure, and the crude product obtained was purified by column chromatography (eluent: petroleum ether/ethyl acetate, v/v = 20/1) to give the final white solid product tert-butyl 2-bromo-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-carboxylate (6.21 g, 93% yield).

References

[1] Patent: CN104497008, 2016, B. Location in patent: Paragraph 0190; 0195; 0196
[2] European Journal of Medicinal Chemistry, 2018, vol. 145, p. 389 - 403

TERT-BUTYL 2-BROMO-6,7-DIHYDROTHIENO[3,2-C]PYRIDINE-5(4H)CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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TERT-BUTYL 2-BROMO-6,7-DIHYDROTHIENO[3,2-C]PYRIDINE-5(4H)CARBOXYLATE Suppliers

China 69 China Hong Kong 1 Germany 2 India 1 United States 16 Global 89

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Xunteng International Trading Co.,Limited

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View Lastest Price from TERT-BUTYL 2-BROMO-6,7-DIHYDROTHIENO[3,2-C]PYRIDINE-5(4H)CARBOXYLATE manufacturers

Career Henan Chemical Co

Product: TERT-BUTYL 2-BROMO-6,7-DIHYDROTHIENO[3,2-C]PYRIDINE-5(4H)CARBOXYLATE 949922-62-7
Price: US $2.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: customise
Release date: 2018-08-09

949922-62-7, TERT-BUTYL 2-BROMO-6,7-DIHYDROTHIENO[3,2-C]PYRIDINE-5(4H)CARBOXYLATERelated Search:

Dibenzothiophene 2-BROMO-4,5,6,7-TETRAHYDROTHIENO[3,2-C]PYRIDINE [2-(5-BROMO-THIOPHEN-2-YL)-ETHYL]-CARBAMIC ACID TERT-BUTYL ESTER TERT-BUTYL 2-BROMO-6,7-DIHYDROTHIENO[3,2-C]PYRIDINE-5(4H)CARBOXYLATE

TERT-BUTYL 2-BROMO-6,7-DIHYDROTHIENO[3,2-C]PYRIDINE-5(4H)CARBOXYLATE

2-Bromo-5-Boc-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

2-c]pyridine-5(4H)-carboxylate

tert-butyl 2-broMo-4H,5H,6H,7H-thieno[3,2-c]pyridine-5-carboxylate

tert-Butyl 2-bromo-6,7-dihydrothieno[3,2-c]pyridine-5(4H)

2-Bromo-6,7-dihydro-4H-thieno[3,2-c]pyridine-5-carboxylic acid tert-butyl ester

Thieno[3,2-c]pyridine-5(4H)-carboxylic acid, 2-bromo-6,7-dihydro-, 1,1-dimethylethyl ester

2-bromo-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-carboxylic acid tert-butyl ester

N-Boc-2-bromo-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

tert-butyl 2-bromo-6,7-dihydro-4H-thieno[3,2-c]pyridine-5-carboxylate

949922-62-7

Heterocycle-Pyridine series

CHIRAL CHEMICALS