ChemicalBook > CAS DataBase List > 3-FLUORO-4-METHOXYPHENOL

3-FLUORO-4-METHOXYPHENOL

Product Name
3-FLUORO-4-METHOXYPHENOL
CAS No.
452-11-9
Chemical Name
3-FLUORO-4-METHOXYPHENOL
Synonyms
3-FLUORO-4-METHOXYPHENOL;2-Fluoro-4-hydroxyanisole;Phenol, 3-fluoro-4-methoxy-;4-Aminomethyl-4-(3-bromo-phenyl)-piperidine-1-carboxylic acid tert-butyl ester
CBNumber
CB01509038
Molecular Formula
C7H7FO2
Formula Weight
142.13
MOL File
452-11-9.mol
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3-FLUORO-4-METHOXYPHENOL Property

Melting point:
54-55 °C
Boiling point:
248.2±20.0 °C(Predicted)
Density 
1.224±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
9.46±0.18(Predicted)
Appearance
Light yellow to brown Solid
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Safety

HS Code 
2909309090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
F593395
Product name
3-Fluoro-4-methoxyphenol
Packaging
5g
Price
$285
Updated
2021/12/16
Apolloscientific
Product number
PC6365
Product name
3-Fluoro-4-methoxyphenol
Packaging
1g
Price
$37
Updated
2021/12/16
SynQuest Laboratories
Product number
2607-3-51
Product name
3-Fluoro-4-methoxyphenol
Packaging
1g
Price
$48
Updated
2021/12/16
Matrix Scientific
Product number
119114
Product name
3-Fluoro-4-methoxyphenol
Purity
95+%
Packaging
1g
Price
$64
Updated
2021/12/16
SynQuest Laboratories
Product number
2607-3-51
Product name
3-Fluoro-4-methoxyphenol
Packaging
5G
Price
$199
Updated
2021/12/16
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3-FLUORO-4-METHOXYPHENOL Chemical Properties,Usage,Production

Uses

3-Fluoro-4-methoxyphenol is used in the preparation of non-peptidic NPBWR1 (GPR7) antagonists.

Synthesis

946833-20-1

452-11-9

Synthesis of 3-fluoro-4-methoxyphenol (14): 20 g of 3-fluoro-4-methoxyphenyl acetate (13, 0.11 mol) was dissolved in 200 ml of ethanol and 100 ml of 20% sodium hydroxide (NaOH) solution was added slowly. The reaction mixture was stirred at room temperature for 3 hours. Subsequently, the reaction solution was washed with water and acidified with 6N hydrochloric acid (HCl). The separated oil was extracted with ether and the extract was dried with anhydrous magnesium sulfate (MgSO4). After removal of the solvent under reduced pressure, a solid residue was obtained, which was purified by recrystallization from hexane, resulting in 13 g of the target product (83.3% yield).

References

[1] Patent: US2008/176920, 2008, A1. Location in patent: Page/Page column 15
[2] Patent: US2011/105527, 2011, A1. Location in patent: Page/Page column 18
[3] Patent: WO2014/210167, 2014, A1. Location in patent: Page/Page column 8

3-FLUORO-4-METHOXYPHENOL Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-FLUORO-4-METHOXYPHENOL manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
3-FLUORO-4-METHOXYPHENOL 452-11-9
Price
US $25.00-12.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200000KG
Release date
2024-08-05
Shaanxi Dideu Medichem Co. Ltd
Product
3-Fluoro-4-methoxyphenol 452-11-9
Price
US $1.00-1.60/KG
Min. Order
1KG
Purity
99%+
Supply Ability
10000KG
Release date
2024-04-24
Career Henan Chemical Co
Product
3-FLUORO-4-METHOXYPHENOL 452-11-9
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500kg
Release date
2019-12-25

452-11-9, 3-FLUORO-4-METHOXYPHENOLRelated Search:

1,4-DIMETHOXY-2-FLUOROBENZENE 2,3-DIFLUORO-4-METHOXYPHENOL 1,4-DIFLUORO-2,5-DIMETHOXYBENZENE 1,4-DIMETHOXYTETRAFLUOROBENZENE 4-BENZYLOXY-3-FLUORO-PHENOL 1,4-BIS(2,2,2-TRIFLUOROETHOXY)TETRAFLUOROBENZENE 1,4-BIS(TERT-BUTOXY)TETRAFLUOROBENZENE 1,4-BIS(ETHOXY)TETRAFLUOROBENZENE TETRAFLUORO-1,4-BIS(2,2,3,3-TETRAFLUOROPROPOXY)BENZENE AKOS BBS-00005190 AKOS BBS-00005175 AKOS BBS-00005159 SALOR-INT L142344-1EA AKOS BBS-00005191 AKOS BBS-00005158 1-[4-(BENZYLOXY)-3-FLUOROPHENOXY]-2-BROMO-4-NITROBENZENE AKOS BBS-00005180 AKOS BBS-00005189

  • 3-FLUORO-4-METHOXYPHENOL
  • 4-Aminomethyl-4-(3-bromo-phenyl)-piperidine-1-carboxylic acid tert-butyl ester
  • 2-Fluoro-4-hydroxyanisole
  • Phenol, 3-fluoro-4-methoxy-
  • 452-11-9
  • Phenol&Thiophenol&Mercaptan