(2R,3S)-3-(tert-Butoxycarbonylamino)-1-chloro-2-hydroxy-4-phenylbutane

Product Name: (2R,3S)-3-(tert-Butoxycarbonylamino)-1-chloro-2-hydroxy-4-phenylbutane
CAS No.: 162536-40-5
Chemical Name: (2R,3S)-3-(tert-Butoxycarbonylamino)-1-chloro-2-hydroxy-4-phenylbutane
Synonyms: (2R,3S)-3-(tert-Butoxycarbonylamino)-1-chloro-2-hydroxy-4-ph...;tert-Butyl ((2S,3R)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbaMate;tert-butyl N-[(2S,3R)-4-chloro-3-hydroxy-1-phenylbutan-2-yl]carbamate;(2R,3S)-3-(tert-Butoxycarbonylamino)-1-chloro-2-hydroxy-4-phenylbutane;(2R,3S)-N-tert-Butoxycarbonyl-3-amino-1-chloro-2-hydroxy-4-phenylbutane;(2R,3S)-2-Hydroxy-3-((tert-butoxycarbonyl)amino)-4-phenyl-1-chlorobutane;(2R,3S)-1-Chloro-2-hydroxy-3-N-(tert-butoxycarbonyl)amino-4-phenylbutane;N-[(1S,2R)-3-Chloro-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester;Carbamic acid, N-[(1S,2R)-3-chloro-2-hydroxy-1-(phenylmethyl)propyl]-, 1,1-dimethylethyl ester
CBNumber: CB01512395
Molecular Formula: C15H22ClNO3
Formula Weight: 299.79
MOL File: 162536-40-5.mol

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(2R,3S)-3-(tert-Butoxycarbonylamino)-1-chloro-2-hydroxy-4-phenylbutane Property

Melting point:: 83-84℃
Boiling point:: 460.5±45.0 °C(Predicted)
Density: 1.153
storage temp.: 2-8°C
pka: 11.92±0.46(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific

Product number: 4431CR
Product name: Tert-Butyl((2S,3R)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbamate
Packaging: 1g
Price: $104
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CCH0006626
Product name: (2R,3S)-3-(TERT-BUTOXYCARBONYLAMINO)-1-CHLORO-2-HYDROXY-4-PHENYLBUTANE
Purity: 95.00%
Packaging: 5MG
Price: $500.24
Updated: 2021/12/16

Ambeed

Product number: A691852
Product name: tert-Butyl((2S,3R)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbamate
Purity: 97%
Packaging: 250mg
Price: $6
Updated: 2021/12/16

Ambeed

Product number: A691852
Product name: tert-Butyl((2S,3R)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbamate
Purity: 97%
Packaging: 1g
Price: $15
Updated: 2021/12/16

Ambeed

Product number: A691852
Product name: tert-Butyl((2S,3R)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbamate
Purity: 97%
Packaging: 5g
Price: $44
Updated: 2021/12/16

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(2R,3S)-3-(tert-Butoxycarbonylamino)-1-chloro-2-hydroxy-4-phenylbutane Chemical Properties,Usage,Production

Synthesis

102123-74-0

165727-45-7

162536-40-5

The synthesis of tert-butyl (1S,2S)-(1-benzyl-3-chloro-2-hydroxypropyl)carbamate and (2R,3S)-3-tert-butoxycarbonyl-1-chloro-2-hydroxy-4-phenylbutane was carried out via ruthenium-catalyzed asymmetric hydrogenation using (3S)-3-(tert-butoxycarbonyl)amino-1-chloro-4-phenyl-2-butanone as the starting material. The experiments were catalyzed using different ruthenium ligands under the following reaction conditions: substrate 1 mmol, substrate to catalyst ratio (S/C) of 100:1, solvent 4 mL methanol, and reaction time 20 h (not optimized). The reaction temperature and pressure were adjusted according to the catalyst type, and the results are shown in Table 1.Entry 1 used Ru(S-Xyl-P-Phos)(acac) as the catalyst and was reacted at 50 °C and 1 bar pressure, resulting in a conversion of 51%, with the major product in the (2R,3S)-configuration, and an enantiomeric excess (de) of 82%.Entry 2 used Ru(SP -Phos)Cl2(dmf) as a catalyst at 65 °C and 20 bar pressure resulted in 89% conversion with the same (2R,3S)-configuration as the major product and an enantiomeric excess (de) of 79%.

References

[1] Journal of Medicinal Chemistry, 1994, vol. 37, # 12, p. 1758 - 1768
[2] Journal of Medicinal Chemistry, 1994, vol. 37, # 12, p. 1758 - 1768
[3] Journal of Organic Chemistry, 2004, vol. 69, # 21, p. 7344 - 7347
[4] Journal of Organic Chemistry, 2004, vol. 69, # 21, p. 7391 - 7394
[5] Journal of Organic Chemistry, 2004, vol. 69, # 21, p. 7391 - 7394

(2R,3S)-3-(tert-Butoxycarbonylamino)-1-chloro-2-hydroxy-4-phenylbutane Preparation Products And Raw materials

Raw materials

Preparation Products

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(2R,3S)-3-(tert-Butoxycarbonylamino)-1-chloro-2-hydroxy-4-phenylbutane Suppliers

China 61 India 4 United States 3 Global 68

Daicel Chiral Technologies (China)CO.,LTD

Tel: 021-50460086-9 15921403865
Fax: +86-21-50462321
Email: han_yajun@dctc.daicel.com
Country: China
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Shanghai T&W Pharmaceutical Co., Ltd.

Tel: +86 21 61551611
Fax: +86 21 50676805
Country: China
ProdList: 9891
Advantage: 58

SynAsst Chemical.

Tel: 021-60343070
Fax: 021-35122006
Country: China
ProdList: 12740
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Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
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Wuhan Dahua Pharmaceutical Co., Ltd.

Tel: 027-59262863 13277907145 3091977954
Fax: 027-59420980
Country: China
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Credit Asia Chemical Co., Ltd.

Tel: +86 (21) 61124340
Fax: +86 (21) 6129-4103
Country: China
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ChengDu TongChuangYuan Pharmaceutical Co.Ltd

Tel: 028-83379370 13880556291
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Email: tcy@tcypharm.com
Country: China
ProdList: 7218
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Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
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Henan Kangqian Medical Technology Co., Ltd.

Tel: +86-0371-69197788
Fax: +86-371-86568877
Email: kangmedicine@hotmail.com
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ProdList: 76
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Capot Chemical Co.,Ltd.

Tel: +86-（0）57185586718; +8613336195806
Fax: +86-571-85864795
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162536-40-5, (2R,3S)-3-(tert-Butoxycarbonylamino)-1-chloro-2-hydroxy-4-phenylbutaneRelated Search:

tert-butyl(4-(3-(dimethoxyphosphoryl)-2-oxopropyl)phenyl)carbamate tert-butyl 7-chloro-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxylate (2R,3S)-3-(tert-Butoxycarbonyl)amino-1,2-epoxy-4-phenylbutane (2S,3S)-3-(Benzyloxycarbonylamino)-1-chloro-2-hydroxy-4-phenylbutane (2S,3S)-1,2-Epoxy-3-(Boc-amino)-4-phenylbutane (2R)-4-(PhenylMethyl)-2-MorpholineMethanaMine (2R,5R)-2,5-DIMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER (2R,5R)-1,6-Diphenylhexane-2,5-diaMine dihydrochloride 2-Pyrrolidinecarbonitrile,(2R)- Benzeneacetic acid, alpha-amino-alpha-methyl-, (alphaR)- (9CI) N-BOC-3-CHLOROPROPYLAMINE (2R,3S)-3-(tert-Butoxycarbonylamino)-1-chloro-2-hydroxy-4-phenylbutane [1(S)-(4-BENZYLOXY-BENZYL)-3-CHLORO-2(R)-HYDROXY-PROPYL]-CARBAMIC ACID TERT-BUTYL ESTER [1(S)-(4-NITRO-BENZYL)-3-CHLORO-2(R)-HYDROXY-PROPYL]-CARBAMIC ACID TERT-BUTYL ESTER

(2R,3S)-3-(tert-Butoxycarbonylamino)-1-chloro-2-hydroxy-4-phenylbutane

Carbamic acid, N-[(1S,2R)-3-chloro-2-hydroxy-1-(phenylmethyl)propyl]-, 1,1-dimethylethyl ester

(2R,3S)-1-Chloro-2-hydroxy-3-N-(tert-butoxycarbonyl)amino-4-phenylbutane

(2R,3S)-N-tert-Butoxycarbonyl-3-amino-1-chloro-2-hydroxy-4-phenylbutane

N-[(1S,2R)-3-Chloro-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester

tert-Butyl ((2S,3R)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbaMate

tert-butyl N-[(2S,3R)-4-chloro-3-hydroxy-1-phenylbutan-2-yl]carbamate

(2R,3S)-3-(tert-Butoxycarbonylamino)-1-chloro-2-hydroxy-4-ph...

(2R,3S)-2-Hydroxy-3-((tert-butoxycarbonyl)amino)-4-phenyl-1-chlorobutane

162536-40-5

API intermediates