2,4-Dihydroxy-5-isopropylbenzoic acid
- Product Name
- 2,4-Dihydroxy-5-isopropylbenzoic acid
- CAS No.
- 1184181-48-3
- Chemical Name
- 2,4-Dihydroxy-5-isopropylbenzoic acid
- Synonyms
- 2,4-Dihydroxy-5-isopropylbenzoic acid;2,4-DIHYDROXY-5-(PROPAN-2-YL)BENZOIC ACID;Benzoic acid, 2,4-dihydroxy-5-(1-methylethyl)-;2,4-Dihydroxy-5-isopropylbenzoic acid ISO 9001：2015 REACH
- CBNumber
- CB01513695
- Molecular Formula
- C10H12O4
- Formula Weight
- 196.2
- MOL File
- 1184181-48-3.mol
2,4-Dihydroxy-5-isopropylbenzoic acid Property
- Boiling point:
- 395.2±27.0 °C(Predicted)
- Density
- 1.317±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 3.48±0.10(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C10H12O4/c1-5(2)6-3-7(10(13)14)9(12)4-8(6)11/h3-5,11-12H,1-2H3,(H,13,14)
- InChIKey
- JAMMFVLHQOLNOP-UHFFFAOYSA-N
- SMILES
- C(O)(=O)C1=CC(C(C)C)=C(O)C=C1O
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 133461
- Product name
- 2,4-Dihydroxy-5-isopropylbenzoicacid
- Purity
- 97%
- Packaging
- 5g
- Price
- $1440
- Updated
- 2021/12/16
- Product number
- 133461
- Product name
- 2,4-Dihydroxy-5-isopropylbenzoicacid
- Purity
- 97%
- Packaging
- 10g
- Price
- $1980
- Updated
- 2021/12/16
- Product number
- 2119DV
- Product name
- 2,4-Dihydroxy-5-isopropylbenzoicacid
- Packaging
- 10g
- Price
- $2588
- Updated
- 2021/12/16
- Product number
- A130543
- Product name
- 2,4-Dihydroxy-5-isopropylbenzoicacid
- Purity
- 97%
- Packaging
- 100mg
- Price
- $77
- Updated
- 2021/12/16
- Product number
- A130543
- Product name
- 2,4-Dihydroxy-5-isopropylbenzoicacid
- Purity
- 97%
- Packaging
- 250mg
- Price
- $122
- Updated
- 2021/12/16
2,4-Dihydroxy-5-isopropylbenzoic acid Chemical Properties,Usage,Production
Synthesis
943519-37-7
1184181-48-3
General procedure for the synthesis of 2,4-dihydroxy-5-isopropylbenzoic acid from methyl 2,4-dihydroxy-5-isopropylbenzoate: the reaction was carried out by stirring the methyl 2,4-dihydroxy-5-isopropylbenzoate (0.24 g, 0.97 mmol) with lithium hydroxide (1 g) in a solvent mixture of methanol (10 mL) and water (10 mL) for 12 h at 50 °C, the reaction was was carried out under argon protection and equipped with a reflux condenser. Upon completion of the reaction, the reaction mixture was neutralized to pH 6 with 6N hydrochloric acid and subsequently extracted three times with ethyl acetate. The organic layers were combined, dried with anhydrous sodium sulfate, concentrated under reduced pressure and finally purified by medium pressure liquid chromatography (MPLC) to afford 2,4-dihydroxy-5-isopropylbenzoic acid in 100% yield. The thin layer chromatography (TLC) Rf value was 0.23 (ethyl acetate:hexane = 3:7).1H NMR (400 MHz, CD3OD) δ 7.68 (s, 1H), 6.35 (s, 1H), 3.25-3.22 (m, 1H), 1.27 (d, J = 4.0 Hz, 6H).13C NMR (100 MHz, CD3OD) δ 173.8, 163.3, 163.1, 129.2, 128.7, 105.4, 103.1, 27.7, 23.2.
References
[1] European Journal of Medicinal Chemistry, 2016, vol. 124, p. 1069 - 1080
[2] Patent: KR101789269, 2017, B1. Location in patent: Paragraph 0046; 0048; 0057; 0058
[3] European Journal of Medicinal Chemistry, 2018, vol. 143, p. 390 - 401
2,4-Dihydroxy-5-isopropylbenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
2,4-Dihydroxy-5-isopropylbenzoic acid Suppliers
- Tel
- Fax
- 86-21-57758967
- sales@boylechem.com
- Country
- China
- ProdList
- 2922
- Advantage
- 55
- Tel
- 15026594951
- Fax
- 0556-5030632
- rs@raise-chem.com
- Country
- China
- ProdList
- 4677
- Advantage
- 55
- Tel
- 0086-573-82585213
- Fax
- 0086-573-82585233
- bai@chimicalabs.com
- Country
- China
- ProdList
- 861
- Advantage
- 64
- Tel
- 025-66028182 17714375163
- yftan@aikonchem.com
- Country
- China
- ProdList
- 16676
- Advantage
- 50
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 19906241957
- Fax
- -
- 1557216087@qq.com
- Country
- China
- ProdList
- 1853
- Advantage
- 55
- Tel
- +86 18721201413
- Fax
- +86 (21) 5775-8967
- sales@biopharmaleader.com
- Country
- China
- ProdList
- 1720
- Advantage
- 58
- Tel
- +86-29-89586680 +86-15129568250
- 1026@dideu.com
- Country
- China
- ProdList
- 18895
- Advantage
- 58
- Tel
- +86-0371-86658258 +8613203830695
- Fax
- 0371-86658258
- laboratory@coreychem.com
- Country
- China
- ProdList
- 30227
- Advantage
- 58
- Tel
- 0371-63284658 18135795563
- Fax
- QQ:2885349392
- 3905209149@qq.com
- Country
- China
- ProdList
- 9882
- Advantage
- 58