8-BROMO-2-CHLOROQUINAZOLINE

Product Name: 8-BROMO-2-CHLOROQUINAZOLINE
CAS No.: 956100-63-3
Chemical Name: 8-BROMO-2-CHLOROQUINAZOLINE
Synonyms: 2-chloro-8-bromoquinazoline;8-BROMO-2-CHLOROQUINAZOLINE;8-BroMo-2-chloroquinazoli...;Quinazoline, 8-bromo-2-chloro-;8-Bromo-2-chloroquinazoline 97%
CBNumber: CB01517840
Molecular Formula: C8H4BrClN2
Formula Weight: 243.49
MOL File: 956100-63-3.mol

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8-BROMO-2-CHLOROQUINAZOLINE Property

Boiling point:: 309.7±24.0 °C(Predicted)
Density: 1.762
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -1.09±0.30(Predicted)
Appearance: Yellow to orange Solid

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Safety

Risk Statements: 41
Safety Statements: 26-39
RIDADR: UN2811
HazardClass: IRRITANT
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B684733
Product name: 8-Bromo-2-chloroquinazoline
Packaging: 250mg
Price: $55
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB42522
Product name: 8-Bromo-2-chloroquinazoline
Packaging: 1g
Price: $425
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 38143
Product name: 8-Bromo-2-chloroquinazoline
Purity: 95+%
Packaging: 1g
Price: $495
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H32-D-88
Product name: 8-Bromo-2-chloroquinazoline
Packaging: 1g
Price: $608
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB42522
Product name: 8-Bromo-2-chloroquinazoline
Packaging: 2g
Price: $680
Updated: 2021/12/16

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8-BROMO-2-CHLOROQUINAZOLINE Chemical Properties,Usage,Production

Synthesis

956100-62-2

956100-63-3

General procedure for the synthesis of 8-bromo-2-chloroquinazoline from 4-amino-8-bromo-2-chloroquinazoline: 8-bromo-2-chloroquinazolin-4-amine (12.93 g, 50 mmol) was dissolved in THF (500 mL) under stirring conditions, and isoamyl nitrite (23.43 g, 200 mmol) was added slowly dropwise over a dropwise period of 3 hours. Subsequently, the reaction mixture was continued to be stirred at 60 °C for 40 min. Upon completion of the reaction, the progress of the reaction was monitored by TLC (unfolding agent: PE:EA = 1:1). When the reaction was complete, the mixture was cooled to room temperature and the solvent was removed by distillation under reduced pressure. The residue was dissolved in DCM (300 mL) and the organic layer was washed sequentially with brine (100 mL) and water (100 mL). The organic layer was dried over anhydrous Na2SO4 and purified by column chromatography (eluent: DCM:PE = 1:1) to afford the target compound 8-bromo-2-chloroquinazoline as a yellow solid (8.21 g, 67% yield).1H NMR (DMSO-d6, 400 MHz): δ 9.66 (s, 1H), 8.45 (dd, J = 0.8, 7.6 Hz, 1H), 8.26 (dd, J = 0.8, 8.0 Hz, 1H), 7.73 (dd, J = 7.6, 8.0 Hz, 1H).

References

[1] Patent: WO2007/125405, 2007, A2. Location in patent: Page/Page column 25; 81-82
[2] Patent: EP3287463, 2018, A1. Location in patent: Paragraph 0191; 0195
[3] Patent: WO2015/27222, 2015, A2. Location in patent: Paragraph 0216
[4] Patent: US2018/208604, 2018, A1. Location in patent: Paragraph 0484-0485

8-BROMO-2-CHLOROQUINAZOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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8-BROMO-2-CHLOROQUINAZOLINE Suppliers

China 109 India 1 United Kingdom 2 United States 14 Global 126

Shanghai Boyle Chemical Co., Ltd.

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