2,5-dibromo-4-nitro-1H-imidazole
- Product Name
- 2,5-dibromo-4-nitro-1H-imidazole
- CAS No.
- 6154-30-9
- Chemical Name
- 2,5-dibromo-4-nitro-1H-imidazole
- Synonyms
- Nsc 222400;2,5-dibromo-4-nitro;2,4-Dibromo-5-nitroimidazole;2,5-Dibromo-4-nitroimidazole;Imidazole, 2,4-dibromo-5-nitro-;2,4-Dibromo-5-nitro-1H-imidazole;2,5-dibromo-4-nitro-1H-imidazole;2,4(5)-dibromo-5(4)-nitroimidazole;1H-IMidazole, 2,4-dibroMo-5-nitro-;1H-Imidazole, 2,5-dibromo-4-nitro-
- CBNumber
- CB01527904
- Molecular Formula
- C3HBr2N3O2
- Formula Weight
- 270.87
- MOL File
- 6154-30-9.mol
2,5-dibromo-4-nitro-1H-imidazole Property
- Melting point:
- >270 °C
- Boiling point:
- 396℃
- Density
- 2.575
- Flash point:
- 193℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 2.93±0.10(Predicted)
- Appearance
- White to off-white Solid
- CAS DataBase Reference
- 6154-30-9
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CS-0060033
- Product name
- 2,5-Dibromo-4-nitro-1H-imidazole
- Purity
- 99.03%
- Packaging
- 1g
- Price
- $52
- Updated
- 2021/12/16
- Product number
- CS-0060033
- Product name
- 2,5-Dibromo-4-nitro-1H-imidazole
- Purity
- 99.03%
- Packaging
- 250mg
- Price
- $53
- Updated
- 2021/12/16
- Product number
- CS-0060033
- Product name
- 2,5-Dibromo-4-nitro-1H-imidazole
- Purity
- 99.03%
- Packaging
- 10g
- Price
- $248
- Updated
- 2021/12/16
- Product number
- CS-0060033
- Product name
- 2,5-Dibromo-4-nitro-1H-imidazole
- Purity
- 99.03%
- Packaging
- 5g
- Price
- $146
- Updated
- 2021/12/16
- Product number
- CS-0060033
- Product name
- 2,5-Dibromo-4-nitro-1H-imidazole
- Purity
- 99.03%
- Packaging
- 25g
- Price
- $447
- Updated
- 2021/12/16
2,5-dibromo-4-nitro-1H-imidazole Chemical Properties,Usage,Production
Description
2,5-dibromo-4-nitro-1H-imidazole is an important intermediate in the synthesis of bactericidal drug Delamanid, and 2-bromo-4-nitroimidazole (II) is also used to synthesize other nitroimidazoles under development.
Uses
2,4-Dibromo-5-nitro-1H-imidazole is an intermediate in organic synthesis and pharmaceutical intermediate, which can be used in laboratory research and development process and chemical production process.
Preparation
After reacting 4-nitroimidazole with sodium bicarbonate, bromine was added to finally obtain 2,5-dibromo-4-nitro-1H-imidazole.
Synthesis
3034-38-6
6154-30-9
The general procedure for the synthesis of 2,5-dibromo-4-nitro-1H-imidazole from 4-nitroimidazole was as follows: 4-nitroimidazole (100 g, 884 mmol), sodium bicarbonate (164 g, 1.94 mol), and water (500 ml) were mixed with vigorous stirring. Subsequently, bromine (106 ml, 2.07 mol) was added slowly and dropwise. The reaction mixture was stirred at room temperature (23°C to 25°C) for 6 h. Vigorous foaming was observed during the dropwise addition. Next, the reaction mixture was heated to 50°C to 55°C and stirring was continued for 4 hours. Upon completion of the reaction, water (400 ml) and concentrated hydrochloric acid (80 ml) were sequentially added to the mixture under ice bath cooling (temperature controlled at 10°C or lower) and stirring was continued for 1 hour. The resulting crystals were collected by filtration. The resulting crystals were first washed with 400 ml of water on filter paper, followed by two dispersion washes with 800 ml of water. Finally, the crystals were air dried at 50°C for 16 hours. A light yellow crystalline product of 213 g was obtained with a yield of 88.9%. The characteristic absorption peaks of the infrared spectrum (KBr press method) of the product were 3074, 1548, 1468, 1392, 1361, 1345, 1310, 1259, 1172, 1066, 975, 830, 667 cm-1.
References
[1] Patent: WO2005/77913, 2005, A1. Location in patent: Page/Page column 72-73
[2] Organic Process Research and Development, 2013, vol. 17, # 9, p. 1149 - 1155
[3] Patent: EP1553088, 2005, A1. Location in patent: Page/Page column 46
[4] Patent: KR101650716, 2016, B1. Location in patent: Paragraph 0082; 0083
2,5-dibromo-4-nitro-1H-imidazole Preparation Products And Raw materials
Raw materials
Preparation Products
2,5-dibromo-4-nitro-1H-imidazole Suppliers
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 86-027-67849912
- Fax
- 86-027-87531808
- sales@chemwish.com
- Country
- China
- ProdList
- 35896
- Advantage
- 56
- Tel
- 025-83697070
- Fax
- +86-25-83453306
- info@chemlin.com.cn
- Country
- China
- ProdList
- 16075
- Advantage
- 64
- Tel
- +86-571-85224801; 13588483690
- Fax
- 0571-85241599
- chemipanda2010@163.com
- Country
- China
- ProdList
- 111
- Advantage
- 62
- Tel
- +86057186818502 13588463833
- Fax
- Pls mail us for more information!
- info@sagechem.com
- Country
- China
- ProdList
- 10266
- Advantage
- 58
- Tel
- +86-512-68095917 17712685869
- Fax
- +86-512-68417933
- sales@bek.com.cn
- Country
- China
- ProdList
- 146
- Advantage
- 59
- Tel
- 021-60343070
- Fax
- 021-35122006
- Country
- China
- ProdList
- 12740
- Advantage
- 55
- Tel
- 0319-5801333-8008 15630992918
- sales@summedchem.com
- Country
- China
- ProdList
- 965
- Advantage
- 58
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60
- Tel
- 025-57018978 18251899859
- Fax
- 025-57018008
- sales@chalf-pharm.com
- Country
- China
- ProdList
- 5674
- Advantage
- 50
- Tel
- 0573-11111111-1111 18969316891
- Fax
- -
- richmol@163.com
- Country
- China
- ProdList
- 449
- Advantage
- 50
- Tel
- 027-67849912
- Fax
- 027-87531808
- sales@chemwish.com
- Country
- China
- ProdList
- 9148
- Advantage
- 60
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 71826
- Advantage
- 60
- Tel
- 028-83379370 13880556291
- Fax
- 028-87747383
- tcy@tcypharm.com
- Country
- China
- ProdList
- 7218
- Advantage
- 58
- Tel
- 021-QQ：65489617 15618227136
- Fax
- 21-5161 9052
- Sales@ATKchemical.com
- Country
- China
- ProdList
- 9125
- Advantage
- 58
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 0751-2886750 13927877953
- Fax
- 0751-2886750
- 3005811397@qq.com
- Country
- China
- ProdList
- 13305
- Advantage
- 58
- Tel
- 027-50664929, 13971561712
- Fax
- 027-50664927 / QQ: 3452835437
- hubxys2001@163.com
- Country
- China
- ProdList
- 1437
- Advantage
- 55
- Tel
- 17836913271
- Fax
- 0374-8348899
- 3224305243@qq.com
- Country
- China
- ProdList
- 2944
- Advantage
- 58
- Tel
- 13062833949; 4006653949 4006653949
- Fax
- QQ: 2136646215
- fred.wen@crcorporation.cn
- Country
- China
- ProdList
- 9757
- Advantage
- 58
- Tel
- 18616776591
- Fax
- 021-54096319
- xuchenghao@sinch.com.cn
- Country
- China
- ProdList
- 206
- Advantage
- 58
- Tel
- 025-58859352 18068836627
- Fax
- (5)02557626880
- dt3@aikonchem.com
- Country
- China
- ProdList
- 15493
- Advantage
- 58
- Tel
- 0531-61320525 15866703830
- figo.gao@foxmail.com
- Country
- China
- ProdList
- 5178
- Advantage
- 58
- Tel
- Fax
- -
- jnyaoyan@163.com
- Country
- China
- ProdList
- 3069
- Advantage
- 58
- Tel
- 025-83453353
- Fax
- 025-83453353
- nj.chemlin@chemlin.com.cn
- Country
- CHINA
- ProdList
- 853
- Advantage
- 58
- Tel
- 13382066392
- Country
- CHINA
- ProdList
- 4877
- Advantage
- 58
- Tel
- 021-000000 13917643586;
- admin@jingshipharmatech.com
- Country
- China
- ProdList
- 9856
- Advantage
- 58
- Tel
- 0371-63315541 13323832564
- Fax
- QQ:3001332135
- 3001332135@qq.com
- Country
- China
- ProdList
- 9972
- Advantage
- 58
- Tel
- 025-58786926 18951781718
- Fax
- 025-58786926
- zbbgz2009@163.com
- Country
- China
- ProdList
- 300
- Advantage
- 58
- Tel
- 4009004166/18616739031 18616739031
- 3007523370@qq.com
- Country
- China
- ProdList
- 52687
- Advantage
- 58
- Tel
- 021-58581007 18019463053
- Fax
- 021-50966098
- sales@coolpharm.com
- Country
- China
- ProdList
- 12878
- Advantage
- 58
- Tel
- meitaochem@126.com
- meitaochem@126.com
- Country
- China
- ProdList
- 19103
- Advantage
- 58
- Tel
- +8615838112936
- alfa10@alfachem.cn
- Country
- China
- ProdList
- 12921
- Advantage
- 58
- Tel
- +8617735180244
- mike_yan@xuanranglobal.com
- Country
- CHINA
- ProdList
- 4017
- Advantage
- 58
- Tel
- +86-0086-577-64498589 +86-15355981851
- Fax
- 0086-577-56994596
- sales@win-winchemical.com
- Country
- China
- ProdList
- 14359
- Advantage
- 58
- Tel
- +86-0371-86658258 +8613203830695
- Fax
- 0371-86658258
- laboratory@coreychem.com
- Country
- China
- ProdList
- 30229
- Advantage
- 58
- Tel
- +86-021-021-50872116 +8613122107989
- contact@fuxinpharm.com
- Country
- China
- ProdList
- 10000
- Advantage
- 58
- Tel
- 0371-0371-53736046 13393710386
- Fax
- QQ:2853979814
- 2853979814@qq.com
- Country
- China
- ProdList
- 9947
- Advantage
- 58
- Tel
- 021-58432009 400-005-6266
- Fax
- 021-58436166
- marketing@energy-chemical.com
- Country
- China
- ProdList
- 44918
- Advantage
- 58
- Tel
- 15092083467
- 18660263263@163.com
- Country
- China
- ProdList
- 2810
- Advantage
- 58
- Tel
- 021-51816796-820 13611835272
- Fax
- 021-5161 3951
- sales2@sunwaypharm.com
- Country
- China
- ProdList
- 44119
- Advantage
- 58
- Tel
- 2383948258 19172820304
- 2383948258@qq.com
- Country
- China
- ProdList
- 12987
- Advantage
- 58
- Tel
- 0751-18902340975/189023400307 18902340307
- Fax
- 0751-2819901
- 3356812514@qq.com
- Country
- China
- ProdList
- 9249
- Advantage
- 58
- Tel
- 400-8210725 4008210725
- malulu@leyan.com
- Country
- China
- ProdList
- 40000
- Advantage
- 58
- Tel
- 400-6005915
- sales@picasso-e.com
- Country
- China
- ProdList
- 39665
- Advantage
- 58
- Tel
- +86(21)5895 0110 19945755304
- sales@chemany.com
- Country
- China
- ProdList
- 9984
- Advantage
- 58
- Tel
- 021-021-50706066 15221275939
- shenlinxing@macklin.cn
- Country
- China
- ProdList
- 29784
- Advantage
- 58
- Tel
- 18621169109
- market03@meryer.com
- Country
- China
- ProdList
- 27987
- Advantage
- 58
- Tel
- 029-81145920 17391631969
- 1046@dideu.com
- Country
- China
- ProdList
- 9996
- Advantage
- 58
- Tel
- 010-50973130 17801761073
- Gsiyu@solarbio.com
- Country
- China
- ProdList
- 50464
- Advantage
- 58