N-T-BOC-4,4-DIFLUOROCYCLOHEXYLAMINE

Product Name: N-T-BOC-4,4-DIFLUOROCYCLOHEXYLAMINE
CAS No.: 675112-67-1
Chemical Name: N-T-BOC-4,4-DIFLUOROCYCLOHEXYLAMINE
Synonyms: N-T-BOC-4,4-DIFLUOROCYCLOHEXYLAMINE;1-(Boc-amino)-4,4-difluorocyclohexane;Tert-butyl4,4-difluorocyclohexylcarbaMate;tert-butyl N-(4,4-difluorocyclohexyl)carbamate;(4,4-Difluoro-cyclohexyl)-carbamic acid tert-butyl ester;Carbamic acid, N-(4,4-difluorocyclohexyl)-, 1,1-dimethylethyl ester
CBNumber: CB0155786
Molecular Formula: C11H19F2NO2
Formula Weight: 235.27
MOL File: 675112-67-1.mol

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N-T-BOC-4,4-DIFLUOROCYCLOHEXYLAMINE Property

Melting point:: 119-122 °C
Boiling point:: 293.2±40.0 °C(Predicted)
Density: 1.09±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 11.46±0.40(Predicted)
Appearance: White to off-white Solid

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Safety

HS Code: 2921309990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H303May be harmfulif swallowed

H320Causes eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Matrix Scientific

Product number: 093657
Product name: tert-Butyl 4,4-difluorocyclohexylcarbamate
Purity: 95+%
Packaging: 500mg
Price: $96
Updated: 2021/12/16

Matrix Scientific

Product number: 093657
Product name: tert-Butyl 4,4-difluorocyclohexylcarbamate
Purity: 95+%
Packaging: 1g
Price: $147
Updated: 2021/12/16

AK Scientific

Product number: 0387AC
Product name: tert-Butyl4,4-difluorocyclohexylcarbamate
Packaging: 500mg
Price: $179
Updated: 2021/12/16

Activate Scientific

Product number: AS14823
Product name: tert-butyl 4,4-Difluorocyclohexylcarbamate
Purity: 95+%
Packaging: 250mg
Price: $180
Updated: 2021/12/16

Activate Scientific

Product number: AS14823
Product name: tert-butyl 4,4-Difluorocyclohexylcarbamate
Purity: 95+%
Packaging: 1g
Price: $390
Updated: 2021/12/16

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N-T-BOC-4,4-DIFLUOROCYCLOHEXYLAMINE Chemical Properties,Usage,Production

Synthesis

179321-49-4

675112-67-1

General procedure for the synthesis of N-Boc-4,4-difluorocyclohexylamine from 4-N-Boc-aminocyclohexanone: To a solution of 1,1-dimethylethyl (4-oxocyclohexyl) carbamate (1 g, 4.69 mmol, 1 eq.) in dichloromethane (15 mL) was added diethylamino sulfur trifluoride (DAST, 1.05 mL, 7.98 mmol. 1.7 eq.) and the reaction mixture was stirred at room temperature for 15 hours. After completion of the reaction, saturated aqueous sodium bicarbonate solution was added and the resulting two-phase mixture was stirred vigorously for 1 hour. The organic and aqueous layers were separated and the aqueous phase was extracted with dichloromethane. All organic phases were combined, dried with anhydrous magnesium sulfate, filtered and concentrated in vacuum to give 1,1-dimethylethyl (4,4-difluorocyclohexyl) carbamate (D277, 1.03 g, 93% yield) as a beige solid, which could be used in the next step without further purification.

References

[1] Patent: WO2004/50619, 2004, A1. Location in patent: Page 71
[2] Patent: WO2013/107405, 2013, A1. Location in patent: Page/Page column 49-50
[3] Patent: TW2017/36341, 2017, A. Location in patent: Paragraph 0489; 0492-0495
[4] Patent: WO2004/94430, 2004, A1. Location in patent: Page 27
[5] Patent: WO2004/111033, 2004, A1. Location in patent: Page 24; 25

N-T-BOC-4,4-DIFLUOROCYCLOHEXYLAMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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N-T-BOC-4,4-DIFLUOROCYCLOHEXYLAMINE Suppliers

Canada 1 China 41 India 1 United States 5 Global 48

Changzhou Huanling Chemical Co., Ltd.

Tel: 0519-89803565 13776850645
Fax: 0519-89803575
Email: info4@huanlingchem.com
Country: China
ProdList: 891
Advantage: 68

Nanjing Norris-Pharm Technology Co., Ltd

Tel: 18652989687
Fax: +86-25-52131256
Email: sales@norris-pharm.com
Country: China
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SynAsst Chemical.

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Country: China
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Cochemical Ltd.

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Fax: 02151602123
Email: sales@cochemical.com
Country: China
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Shanghai AQBioPharma Co., Ltd.

Tel: 13661411401
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ProdList: 2930
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JW & Y Pharmlab Co., Ltd.

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BTC Pharmaceutical CO. Ltd

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Shanghai Qiao Chemical Science Co., Ltd

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Email: info@qiaochem.com
Country: China
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Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Grader reagent

Tel: 18221735425
Email: sales@xinpingchem.com
Country: China
ProdList: 9942
Advantage: 58

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View Lastest Price from N-T-BOC-4,4-DIFLUOROCYCLOHEXYLAMINE manufacturers

Career Henan Chemical Co

Product: N-T-BOC-4,4-DIFLUOROCYCLOHEXYLAMINE 675112-67-1
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-02

675112-67-1, N-T-BOC-4,4-DIFLUOROCYCLOHEXYLAMINERelated Search:

N-T-BOC-4,4-DIFLUOROCYCLOHEXYLAMINE 4,4-DIFLUOROCYCLOHEXANAMINE

N-T-BOC-4,4-DIFLUOROCYCLOHEXYLAMINE

tert-butyl N-(4,4-difluorocyclohexyl)carbamate

Tert-butyl4,4-difluorocyclohexylcarbaMate

1-(Boc-amino)-4,4-difluorocyclohexane

Carbamic acid, N-(4,4-difluorocyclohexyl)-, 1,1-dimethylethyl ester

(4,4-Difluoro-cyclohexyl)-carbamic acid tert-butyl ester

675112-67-1

C11H19F2NO2