ethyl 4-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate

Product Name: ethyl 4-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate
CAS No.: 942920-55-0
Chemical Name: ethyl 4-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate
Synonyms: ethyl 4-broMo-1H-pyrrolo[2;3-b]pyridine-2-carboxylate;ethyl 6-chloro-1H-pyrrolo[2;Ethyl 4-Bromo-7-azaindole-2-carboxylate;ethyl 4-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate;1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, 4-broMo-, ethyl ester
CBNumber: CB01560987
Molecular Formula: C10H9BrN2O2
Formula Weight: 269.09
MOL File: 942920-55-0.mol

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ethyl 4-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate Property

Density: 1.624±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 10.96±0.40(Predicted)
Appearance: White to off-white Solid
InChI: InChI=1S/C10H9BrN2O2/c1-2-15-10(14)8-5-6-7(11)3-4-12-9(6)13-8/h3-5H,2H2,1H3,(H,12,13)
InChIKey: VLZWUULVFAASBC-UHFFFAOYSA-N
SMILES: C12NC(C(OCC)=O)=CC1=C(Br)C=CN=2

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H300Fatal if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: HCH0044870
Product name: ETHYL 4-BROMO-1H-PYRROLO[2,3-B]PYRIDINE-2-CARBOXYLATE
Purity: 95.00%
Packaging: 1G
Price: $947.1
Updated: 2021/12/16

AK Scientific

Product number: W9668
Product name: Ethyl4-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate
Packaging: 1g
Price: $584
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0044870
Product name: ETHYL 4-BROMO-1H-PYRROLO[2,3-B]PYRIDINE-2-CARBOXYLATE
Purity: 95.00%
Packaging: 5G
Price: $2425.5
Updated: 2021/12/16

Chemenu

Product number: CM149573
Product name: ethyl4-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate
Purity: 95%+
Packaging: 1g
Price: $786
Updated: 2021/12/16

Alichem

Product number: 942920550
Product name: Ethyl4-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate
Packaging: 5g
Price: $1424.64
Updated: 2021/12/16

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ethyl 4-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate Chemical Properties,Usage,Production

Uses

Ethyl 4-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate is used in pharmaceutical synthesis and experiments.

Synthesis

287384-82-1

942920-55-0

Step A: Synthesis of ethyl 4-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate Ethyl 1H-pyrrolo[2,3-b]pyridine-2-carboxylate-7-oxide (1 g, 5 mmol) (prepared according to the method disclosed in WO 2000/044753, see Example 6, Step C) was added to a suspension of tetramethylammonium bromide (1.2 g, 7.5 mmol) in N,N-dimethylformamide (50 mL). The reaction mixture was cooled to 0 °C, followed by batchwise addition of methylsulfonic anhydride (1.7 g, 10 mmol). The mixture was warmed to room temperature and stirring was continued for 6 hours. Upon completion of the reaction, the mixture was poured into water (100 mL) and neutralized with 50% aqueous sodium hydroxide solution. The aqueous phase was extracted with ethyl acetate and the organic layer was washed sequentially with brine and deionized water. The organic phase was concentrated under reduced pressure to give the crude product. Purification by SCX column chromatography afforded ethyl 4-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate as a light yellow solid (1 g, 77% yield). 1H NMR (400MHz, DMSO-d6) δ ppm: 1.35 (t, 3H, J=7.1Hz), 4.36 (q, 2H, J=7.1Hz), 7.05 (d, 1H, J=2.0Hz), 7.48 (d, 1H, J=5.1Hz), 8.28 (d, 1H, J=5.1Hz), 12.95 (brs , 1H).

References

[1] Journal of Medicinal Chemistry, 2010, vol. 53, # 10, p. 3973 - 4001
[2] Patent: WO2008/49855, 2008, A2. Location in patent: Page/Page column 54
[3] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 16, p. 4610 - 4614
[4] Patent: US2009/18156, 2009, A1. Location in patent: Page/Page column 18-19
[5] Patent: WO2007/76423, 2007, A2. Location in patent: Page/Page column 96

ethyl 4-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from ethyl 4-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate manufacturers

Career Henan Chemical Co

Product: ethyl 4-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate 942920-55-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2019-12-25

942920-55-0, ethyl 4-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylateRelated Search:

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ethyl 4-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate

3-b]pyridine-2-carboxylate

ethyl 4-broMo-1H-pyrrolo[2

ethyl 6-chloro-1H-pyrrolo[2

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Ethyl 4-Bromo-7-azaindole-2-carboxylate

942920-55-0

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